Gestational Diabetes Mellitus, Perinatal Depression, and Offspring Neurodevelopmental Phenotype

妊娠期糖尿病、围产期抑郁症和后代神经发育表型

• 批准号: 10915172
• 负责人: Lauren Christine Shuffrey
• 金额: $ 24.9万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10915172
• 关键词: Affect; Age Months; Anxiety; Attention; Attentional deficit; Auditory; Award; Behavioral; Biological; Biological Assay; Biomedical Research; Biometry; Birth; Blood; Brain; Buffers; Child; Child Mental Health; Clinical Research; Data; Data Set; Development; Diagnosis; Disease; Electroencephalography; Emotional; Event-Related Potentials; Exposure to; Funding; Future; Gestational Diabetes; Goals; Health; Infant; Inflammation; Inflammatory; Interferon Type II; Interleukin-1 beta; Interleukin-6; Intervention; K-Series Research Career Programs; Knowledge; Kynurenine; Maternal Health; Measures; Medical Records; Memory; Mental Depression; Mental Health; Metabolic; Methodology; Neurodevelopmental Disorder; Newborn Infant; Outcome; Pathway interactions; Perinatal; Phase; Phenotype; Plasma; Postpartum Depression; Postpartum Period; Pregnancy; Proteins; Research; Risk; Risk Factors; Role; Serum; Shapes; Stress; TNF gene; Toddler; Training; Tryptophan; Underrepresented Populations; United States; Venipunctures; Visual; Woman; antepartum depression; cohort; comorbidity; density; disparities in morbidity; ethnic minority population; experience; health disparity; immune function; indexing; maternal depression; maternal risk; modifiable risk; neonatal brain; neural; neurobehavioral; offspring; perinatal mental health; perinatal women; peripartum depression; postnatal; prenatal; prenatal exposure; prospective; psychosocial; racial minority population; skills; social; sustained attention; translational research program

PROJECT SUMMARY This K99 application aims to determine pathways by which gestational diabetes mellitus (GDM) and prenatal depression affect postpartum maternal mental health, neonatal brain function, and toddler brain-behavioral development. There is a bidirectional association between GDM and depression which affect approximately 10% and 13% of women in the United States respectively and disproportionately affect women from ethnic and racial minority groups. Both conditions are independently associated with adverse neurodevelopmental outcomes in offspring including increased risk for social-emotional and attentional deficits. Despite the

项目摘要 本K99应用旨在确定妊娠期糖尿病（GDM）和产前糖尿病的途径。 抑郁症影响产后母亲的心理健康、新生儿的脑功能和幼儿的脑行为 发展妊娠期糖尿病与抑郁症之间存在双向关联， 在美国，分别有10%和13%的女性患有这种疾病， 少数民族群体。这两种情况都独立地与不良的神经发育有关。 对后代的影响包括社交情绪和注意力缺陷的风险增加。尽管