A Hydrogel Ionic Circuit-Based Electrical Stimulation System for Restoration of Denervated Muscles After Peripheral Nerve Injuries

基于水凝胶离子电路的电刺激系统，用于周围神经损伤后失神经肌肉的恢复

• 批准号: 10303900
• 负责人: Bin Duan
• 金额: $ 17.83万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-06 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10303900
• 关键词: Action Potentials; Adverse effects; Animals; Chemical-Induced Change; Clinic; Clinical Trials; Coupled; Development; Device Designs; Devices; Electric Stimulation; Electrodes; Electrons; Exercise; Exploratory/Developmental Grant for Diagnostic Cancer Imaging; Generations; Goals; Human; Hydrogels; In Vitro; Ions; Lead; Mission; Modality; Modeling; Motor; Motor Neurons; Muscle; Muscle function; Muscle rehabilitation; Muscular Atrophy; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Nerve; Outcome; Patients; Peripheral nerve injury; Protocols documentation; Public Health; Quality of life; Rattus; Reaction; Recovery; Rehabilitation Outcome; Rehabilitation therapy; Research; Safety; Sensory; Signal Transduction; System; Technology; Temperature; Testing; Therapeutic; Tissues; Treatment Efficacy; Wireless Technology; base; effective therapy; efficacy evaluation; improved; in vivo; motor recovery; muscular structure; muscular system; novel; pre-clinical; preservation; prevent; restoration; therapy outcome; tool

Project Summary: Muscle electrical stimulation (EStim) is a promising rehabilitation modality for denervated muscles after peripheral nerve injuries. Current muscle EStim devices have limited therapeutic efficacy due to the low EStim intensity they apply. Applying high-intensity EStim to muscles presents a significant challenge. This is because all current devices conduct electron currents. Electrochemical reactions are required to convert the electron currents to the ion currents at the device-tissue interface. These reactions can induce chemical changes and temperature increase that can damage tissues when the EStim intensity is high. Thus, there is a critical need for a new generation of muscle stimulators that can safely apply high-intensity EStim for efficacious preservation of denervated human muscles. The long-term goal is to develop efficacious EStim-based therapy to preserve denervated human muscles after peripheral nerve injuries. The overall objectives of this proposal is to develop a novel EStim device that can safely apply high-intensity EStim to improve the preservation of denervated muscles. In Specific Aim 1, we will determine the optimal EStim device design for safe application of high-intensity EStim. Our working hypothesis is that a wirelessly coupled, ion current-conducting hydrogel ionic circuit (HIC) device does not induce any electrochemical reactions, so it can minimize adverse effects when applying high-intensity EStim. In Specific Aim 2, we will determine the efficacy of high-intensity EStim applied by our device for the preservation of denervated muscles using a pre-clinical rat peripheral nerve injury model. Our working hypothesis is that high- intensity EStim can improve muscle preservation compared to the low-intensity EStim typically used in current studies. The sensory recovery, motor recovery and muscle quality will be evaluated. The rationale for this project is that the development of a wirelessly coupled, completely ion current-based stimulator will significantly increase the EStim intensity that can be applied without causing tissue damage. This will lead to improved muscle rehabilitation outcomes following peripheral nerve injury that is not possible with current stimulators. Our outcome will establish an optimal device design to enable safe and efficient high- intensity EStim application. We will also demonstrate the in vivo efficacy of high-intensity EStim protocol for muscle preservation. Our high impact project will provide a strong justification for further development and testing of our device for treating denervated human muscles following peripheral nerve injuries. This will ultimately lead to better rehabilitation outcomes and improved quality of life for patients suffering from peripheral nerve injury.

项目概述：肌肉电刺激（ESTim）是一种有前途的失神经支配的康复方式。 周围神经损伤后的肌肉。目前的肌肉ESTIM器械由于以下原因而具有有限的治疗功效： 他们应用的低ESTIM强度。将高强度ESTim应用于肌肉是一个重大挑战。 这是因为所有电流器件都传导电子流。需要进行电化学反应才能转化 在装置-组织界面处的电子流到离子流。这些反应可以引起化学反应。 当ESTim强度高时，可能会损害组织的变化和温度升高。由此可见，有一 迫切需要新一代肌肉刺激器，可以安全地应用高强度ESTIM， 保存失神经支配的人体肌肉 长期目标是开发有效的基于EStim的治疗方法，以保护失神经支配的人类肌肉， 周围神经损伤本提案的总体目标是开发一种新型ESTIM器械， 安全地应用高强度ESTIM以改善失神经肌肉的保护。具体目标1： 确定安全应用高强度ESTIM的最佳ESTIM器械设计。我们的工作假设 无线耦合的离子电流传导水凝胶离子电路（HIC）装置不诱导任何 因此，它可以最大限度地减少使用高强度ESTIM时的不良影响。在特定 目的2，我们将确定我们的设备应用的高强度ESTIM用于保存 使用临床前大鼠周围神经损伤模型，我们的假设是- 与目前通常使用的低强度ESTim相比，高强度ESTim可以改善肌肉保护。 问题研究将评价感觉恢复、运动恢复和肌肉质量。 该项目的基本原理是，开发一种无线耦合的，完全基于离子电流的 刺激器将显著增加可应用的ESTim强度，而不会造成组织损伤。这 将导致改善周围神经损伤后的肌肉康复结果，这是不可能的， 电流刺激器我们的成果将建立一个最佳的设备设计，使安全和有效的高- 强度ESTIM应用。我们还将证明高强度EStim方案在体内的疗效， 肌肉保存我们的高影响力项目将为进一步的开发和测试提供强有力的理由 用于治疗周围神经损伤后失神经肌肉的设备。这将最终导致 为周围神经损伤患者提供更好的康复结果和提高生活质量。