Mechanisms of memory integration in brain systems

从我们与环境的互动中学习是大脑最重要的功能之一，然而，这个过程在神经网络层面上是如何以及在哪里发生的，已经证明很难确定。该项目旨在研究大脑中主要的神经调节信号如何协调神经元大集合中基于奖励的学习编码。这些研究将结合新的行为范式和最新的神经科学技术，用于功能映射和操作行为小鼠的特定神经回路。这项研究的结果将导致我们对大脑系统中学习整合的机制及其对行为的影响的理解发生重大转变。

Learning from our interactions with the environment is one of the brain’s most important functions, yet how and where this process takes place at the neural network level has proven difficult to establish. This Project seeks to investigate how major neuromodulatory signals in the brain coordinate the encoding of reward-based learning in large ensembles of neurons. These studies will combine novel behavioural paradigms with the most recent neuroscience techniques for functional mapping and manipulation of specific neural circuits in behaving mice. The outcomes of this research will lead to a significant shift in our understanding of the mechanisms underpinning the integration of learning in brain systems and its implications for behaviour.