Assessing determinants of electrocardiographic alterations and identifying exacerbating factors in pediatric epilepsy
评估心电图改变的决定因素并确定小儿癫痫的恶化因素
基本信息
- 批准号:10302120
- 负责人:
- 金额:$ 36.96万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-07-01 至 2023-12-31
- 项目状态:已结题
- 来源:
- 关键词:AcuteAdultAppearanceArrhythmiaBlood gasCardiacCerebrumCessation of lifeChildChildhoodChronicClinicalDataElectrolytesEnrollmentEpilepsyFrequenciesFutureHealthHeartHeart AbnormalitiesHeart ArrestHeart DiseasesHeart RateHospitalizationHypoxemiaIncidenceIndividualIonsLaboratoriesLeadLongitudinal StudiesMeasurementMechanical ventilationMedicalMedicineModelingMonitorMorphologyOutcomeOxygenPathologyPatientsPediatric HospitalsPediatric cohortPharmaceutical PreparationsPlayPopulation StudyProcessProspective StudiesRelative RisksReportingRiskRisk FactorsRoleSeizuresStressSurrogate MarkersTemperatureTexasTimeVentricular Remodelingbasebiomedical referral centerchildhood epilepsyclinical practicecomorbiditydemographicsfollow-uphigh riskinsightmodifiable riskmortalitymortality riskphysiologic stressorprematureprimary outcomeprospectiverespiratoryrisk predictionsecondary outcomesudden unexpected death in epilepsysupplemental oxygen
项目摘要
PROJECT SUMMARY
Sudden unexpected death in epilepsy (SUDEP) is a significant cause of premature death in childhood-onset
epilepsy. Aberrant cerebral, respiratory and cardiac processes are candidate mechanisms underlying SUDEP.
In support of cardiac mechanism are the findings of higher risk of sudden cardiac arrest in adults with epilepsy,
and inter-ictal and peri-ictal electrocardiographic (ECG) abnormalities suggesting increased cardiac
vulnerability that results from myocardial remodeling. The appearance of high-risk arrhythmias with peri-ictal
hypoxemia suggests that respiratory derangements can also contribute to the cardiac abnormalities in
epilepsy. A longitudinal, population-based study of childhood-onset epilepsy has shown that the cumulative
SUDEP risk increases with increasing epilepsy duration, suggesting that there might be progressive changes
that contribute to mortality risk in adulthood. Our overarching hypothesis is that cardiac electrical
remodeling occurs as function of epilepsy duration and renders the heart vulnerable to stresses such
as seizures or respiratory derangements over time, thereby contributing to SUDEP. For this proposal we
will prospectively follow a cohort of pediatric epilepsy patients without a known ion channelopathy or cardiac
disease, who are managed in a quaternary epilepsy referral center using ECG studies as a surrogate marker.
We will obtain yearly ECG studies and collect clinical and laboratory data associated with each ECG. For
children enrolled in the study who are hospitalized for a respiratory illness during the study period, we will
obtain additional ECGs and collect additional clinical information relating to the hospitalizations. Using
multivariable models controlling for potential confounders such as seizure semiology and frequency, number of
anti-seizure medications, and other factors identified through univariate analyses, we will investigate whether
epilepsy duration is an independent risk factor for abnormal ECG. Using an analogous approach, we will also
evaluate whether an intercurrent respiratory illness is an independent risk factor for abnormal ECG, and
whether epilepsy duration modifies the likelihood of having an abnormal ECG during an intercurrent respiratory
illness.
项目总结
癫痫猝死(SUDEP)是儿童期过早死亡的一个重要原因
癫痫。异常的脑、呼吸和心脏过程是SUDEP的候选机制。
支持心脏机制的是成人癫痫患者心脏骤停风险较高的发现,
发作间期和发作间期的心电图异常提示心脏
由心肌重塑引起的脆弱性。伴发作期高危心律失常的表现
低氧血症提示呼吸紊乱也可导致心脏异常。
癫痫。一项对儿童期癫痫发作的纵向、基于人群的研究表明,
SUDEP的风险随着癫痫持续时间的增加而增加,这表明可能存在进行性变化
这会增加成年后的死亡风险。我们的主要假设是心脏电信号
重塑是癫痫持续时间的函数,并使心脏容易受到这样的压力
随着时间的推移,癫痫发作或呼吸紊乱,从而导致SUDEP。对于这项建议,我们
是否会前瞻性地跟踪一组没有已知离子通道病或心脏疾病的儿童癫痫患者
在第四个癫痫转诊中心使用心电研究作为替代标记物进行管理。
我们将获得每年一次的心电研究,并收集与每一次心电有关的临床和实验室数据。为
参加研究的儿童在研究期间因呼吸道疾病而住院,我们将
获取额外的心电图,并收集与住院相关的额外临床信息。vbl.使用
控制潜在混杂因素的多变量模型,如癫痫症状和发作频率、发作次数
抗癫痫药物,以及通过单因素分析确定的其他因素,我们将调查
癫痫持续时间是心电图异常的独立危险因素。使用类似的方法,我们还将
评估并发呼吸道疾病是否是异常心电图的独立危险因素;以及
癫痫持续时间是否会改变并发呼吸期间出现异常心电图的可能性
生病了。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Yi-Chen Lai其他文献
Yi-Chen Lai的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Yi-Chen Lai', 18)}}的其他基金
PARP-1 activation in seizures and status epilepticus
癫痫发作和癫痫持续状态中的 PARP-1 激活
- 批准号:
8058656 - 财政年份:2009
- 资助金额:
$ 36.96万 - 项目类别:
PARP-1 activation in seizures and status epilepticus
癫痫发作和癫痫持续状态中的 PARP-1 激活
- 批准号:
8250428 - 财政年份:2009
- 资助金额:
$ 36.96万 - 项目类别:
PARP-1 activation in seizures and status epilepticus
癫痫发作和癫痫持续状态中的 PARP-1 激活
- 批准号:
7662022 - 财政年份:2009
- 资助金额:
$ 36.96万 - 项目类别:
PARP-1 activation in seizures and status epilepticus
癫痫发作和癫痫持续状态中的 PARP-1 激活
- 批准号:
8448720 - 财政年份:2009
- 资助金额:
$ 36.96万 - 项目类别:
PARP-1 activation in seizures and status epilepticus
癫痫发作和癫痫持续状态中的 PARP-1 激活
- 批准号:
7826592 - 财政年份:2009
- 资助金额:
$ 36.96万 - 项目类别:
相似海外基金
Co-designing a lifestyle, stop-vaping intervention for ex-smoking, adult vapers (CLOVER study)
为戒烟的成年电子烟使用者共同设计生活方式、戒烟干预措施(CLOVER 研究)
- 批准号:
MR/Z503605/1 - 财政年份:2024
- 资助金额:
$ 36.96万 - 项目类别:
Research Grant
RAPID: Affective Mechanisms of Adjustment in Diverse Emerging Adult Student Communities Before, During, and Beyond the COVID-19 Pandemic
RAPID:COVID-19 大流行之前、期间和之后不同新兴成人学生社区的情感调整机制
- 批准号:
2402691 - 财政年份:2024
- 资助金额:
$ 36.96万 - 项目类别:
Standard Grant
Early Life Antecedents Predicting Adult Daily Affective Reactivity to Stress
早期生活经历预测成人对压力的日常情感反应
- 批准号:
2336167 - 财政年份:2024
- 资助金额:
$ 36.96万 - 项目类别:
Standard Grant
Elucidation of Adult Newt Cells Regulating the ZRS enhancer during Limb Regeneration
阐明成体蝾螈细胞在肢体再生过程中调节 ZRS 增强子
- 批准号:
24K12150 - 财政年份:2024
- 资助金额:
$ 36.96万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Migrant Youth and the Sociolegal Construction of Child and Adult Categories
流动青年与儿童和成人类别的社会法律建构
- 批准号:
2341428 - 财政年份:2024
- 资助金额:
$ 36.96万 - 项目类别:
Standard Grant
Understanding how platelets mediate new neuron formation in the adult brain
了解血小板如何介导成人大脑中新神经元的形成
- 批准号:
DE240100561 - 财政年份:2024
- 资助金额:
$ 36.96万 - 项目类别:
Discovery Early Career Researcher Award
Laboratory testing and development of a new adult ankle splint
新型成人踝关节夹板的实验室测试和开发
- 批准号:
10065645 - 财政年份:2023
- 资助金额:
$ 36.96万 - 项目类别:
Collaborative R&D
Usefulness of a question prompt sheet for onco-fertility in adolescent and young adult patients under 25 years old.
问题提示表对于 25 岁以下青少年和年轻成年患者的肿瘤生育力的有用性。
- 批准号:
23K09542 - 财政年份:2023
- 资助金额:
$ 36.96万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Identification of new specific molecules associated with right ventricular dysfunction in adult patients with congenital heart disease
鉴定与成年先天性心脏病患者右心室功能障碍相关的新特异性分子
- 批准号:
23K07552 - 财政年份:2023
- 资助金额:
$ 36.96万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Issue identifications and model developments in transitional care for patients with adult congenital heart disease.
成人先天性心脏病患者过渡护理的问题识别和模型开发。
- 批准号:
23K07559 - 财政年份:2023
- 资助金额:
$ 36.96万 - 项目类别:
Grant-in-Aid for Scientific Research (C)