The Neural Basis of Active Sensory Gain Suppression in the Somatosensory System
体感系统中主动感觉增益抑制的神经基础
基本信息
- 批准号:10301807
- 负责人:
- 金额:$ 23.51万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-07-01 至 2024-06-30
- 项目状态:已结题
- 来源:
- 关键词:AnimalsAreaAttentionAttention deficit hyperactivity disorderAwardBehaviorBehavioralBrainCalciumCellsCitiesCognitive ScienceCommunicationCortical ColumnCutaneousD CellsDataDevelopmentDiscriminationDoctor of PhilosophyElectrodesElectrophysiology (science)EnsureEnvironmentFacultyFellowshipFingersFunctional Magnetic Resonance ImagingGeneticGoalsGrantHandHumanHuman ResourcesImageInjectionsInterneuronsLeadLearningLinkLocationMacaca mulattaManuscriptsMapsMediatingMentorsMethodsModalityModelingMonitorMonkeysMusNeuraxisNeuronsNew YorkOptical MethodsPerceptionPersonnel ManagementPersonsPlayPopulationPositioning AttributePostdoctoral FellowProcessRecurrenceResearchResearch TrainingRoleScalp structureSensorySeriesSignal TransductionSkinSomatosensory CortexSomatostatinStimulusSystemTactileTechniquesTestingTextureTimeTrainingUniversitiesViralWritinganalytical methodattentional controlautism spectrum disorderbasebrain machine interfacecareercollegeexperimental studyflexibilityhapticsinsightneocorticalneural circuitneuroprosthesisneuroregulationneurotransmissionnonhuman primateoptogeneticsprofessorprogramsreceptive fieldreceptorrelating to nervous systemresponserole modelselective attentionsenior facultysimulationsomatosensorytheoriestranslational impactvibration
项目摘要
PROJECT SUMMARY
The candidate: Dr. Manuel Gomez-Ramirez is an Assistant Professor in the Department of Brain and Cognitive
Sciences (BCS) at the University of Rochester, whose overarching goal is to establish cutting-edge research
program focused on studying neural circuits and spiking dynamics that mediate object sensing and manipulation
with the hands (i.e., haptics). Dr. Gomez-Ramirez completed his Ph.D. at the City College of the City University
of New York studying mechanisms of distracter suppression in humans. He transitioned to studying mechanisms
of tactile perception in non-human primates using multi-electrode single-unit recordings at the Johns Hopkins
University. He conducted a second post-doctoral fellowship at Brown University to learn calcium-based imaging
and optogenetic methods in mice. In his new lab, Dr. Gomez-Ramirez aims to incorporate techniques learned in
his post-doctoral fellowships to study haptics in a non-human primate model.
Research: In this award, Dr. Gomez-Ramirez will study how selective attention controls the sensory gain of
neocortical representations encoding distracter stimuli on the hand. He will use cutting-edge electrophysiological
and neuromodulation methods (i.e., optogenetics) to determine the neural circuit, and its dynamics, that mediate
sensory suppression of distracting tactile inputs. Aim 1 investigates the granularity of attention to modulate
sensory responses via targeting of cells’ receptive field (RF) inhibitory and/or excitatory sub-regions. Aim 2
investigates the precision and flexibility of attention to deploy distracter suppression across different somatotopic
representations in the somatosensory system. Aim 3 tests the role of layer 5 SST neurons in mediating sensory
gain suppression in supragranular layers, the mayor cortical layer of intra- and inter-area communication.
Training, Mentors, Collaborators, and Environment: The major research training goals of this award are to
gain expertise in (1) Cutting-edge population decoding methods (e.g., state-space analytical methods), and (2)
optogenetic stimulation in monkeys to study the how top-down signals regulate local somatosensory cortical
circuits representing relevant vs. irrelevant tactile information. This award will also provide key training in grant
and manuscript writing, personnel management, as well as engagement in extracurricular activities that will
enhance my career and professional development. The K01 scientific mentoring team comprises world-experts
in their respective field of research, and have been role models for mentoring and supporting junior faculty. The
Tenure Oversight team is composed additional senior faculty that will provide another layer of monitoring to
ensure progress in the activities proposed in the tenure plan.
Impact and Significance: Data gathered from studies in this award will inform an R01 application focused on
studying how top-down signals modulate cross-cortical somatosensory circuits mediating object sensing and
manipulation. This award will help provide training on cutting-edge electrophysiological, computational, and
genetic-based optical methods to personnel in the Dr. Gomez-Ramirez’s lab.
项目概要
候选人:Manuel Gomez-Ramirez 博士,大脑与认知系助理教授
罗彻斯特大学科学学院(BCS),其总体目标是建立尖端研究
该项目专注于研究介导物体感知和操纵的神经回路和尖峰动力学
用手(即触觉)。戈麦斯-拉米雷斯博士完成了博士学位。在城市大学城市学院
纽约研究人类干扰干扰抑制机制。他转向研究机制
约翰霍普金斯大学使用多电极单单元记录对非人类灵长类动物的触觉感知
大学。他在布朗大学进行了第二次博士后研究,学习钙基成像
和小鼠光遗传学方法。在他的新实验室中,戈麦斯-拉米雷斯博士旨在将在
他的博士后奖学金用于研究非人类灵长类动物模型中的触觉。
研究:在这个奖项中,戈麦斯-拉米雷斯博士将研究选择性注意力如何控制感官增益
新皮质表征编码手上的干扰刺激。他将利用尖端的电生理学
和神经调节方法(即光遗传学)来确定神经回路及其动力学,从而调节
对分散注意力的触觉输入的感觉抑制。目标 1 研究注意力调节的粒度
通过靶向细胞感受野 (RF) 抑制和/或兴奋子区域的感觉反应。目标2
研究注意力的精确度和灵活性,以在不同的躯体主题上部署分心抑制
体感系统中的表征。目标 3 测试第 5 层 SST 神经元在调节感觉中的作用
颗粒上层的增益抑制,颗粒上层是区域内和区域间通信的主要皮质层。
培训、导师、合作者和环境:该奖项的主要研究培训目标是
获得以下方面的专业知识:(1) 尖端群体解码方法(例如状态空间分析方法),以及 (2)
猴子的光遗传学刺激研究自上而下的信号如何调节局部体感皮质
代表相关与不相关触觉信息的电路。该奖项还将提供资助方面的关键培训
和稿件写作、人事管理以及参与课外活动,这些将
促进我的职业生涯和专业发展。 K01科学指导团队由世界专家组成
在各自的研究领域,并成为指导和支持初级教师的榜样。这
终身教职监督团队由额外的高级教员组成,将为终身教职提供另一层监督。
确保保有权计划中提议的活动取得进展。
影响和意义:从该奖项的研究中收集的数据将为 R01 申请提供信息,重点关注
研究自上而下的信号如何调节跨皮质体感电路介导物体感知和
操纵。该奖项将有助于提供尖端电生理学、计算和
为戈麦斯-拉米雷斯博士实验室的人员提供基于基因的光学方法。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Manuel Gomez-Ramirez其他文献
Manuel Gomez-Ramirez的其他文献
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{{ truncateString('Manuel Gomez-Ramirez', 18)}}的其他基金
Developing an Experimental and Computational Framework for Studying Neural Representations of Tactile Motion on the Hand
开发用于研究手部触觉运动神经表征的实验和计算框架
- 批准号:
10732095 - 财政年份:2023
- 资助金额:
$ 23.51万 - 项目类别:
The Neural Basis of Active Sensory Gain Suppression in the Somatosensory System
体感系统中主动感觉增益抑制的神经基础
- 批准号:
10656346 - 财政年份:2021
- 资助金额:
$ 23.51万 - 项目类别:
The Neural Basis of Active Sensory Gain Suppression in the Somatosensory System
体感系统中主动感觉增益抑制的神经基础
- 批准号:
10440525 - 财政年份:2021
- 资助金额:
$ 23.51万 - 项目类别:
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