Physical Activity and Preservation of Cognitive Function

体力活动和认知功能的保护

• 批准号: 10302710
• 负责人: Priya Palta
• 金额: $ 36.83万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-12-01 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10302710
• 关键词: Address; Administrative Supplement; Adult; African American; Age-associated memory impairment; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Alzheimer’s disease biomarker; Amyloid; Amyloid beta-Protein; Area; Atherosclerosis Risk in Communities; Attention; Award; Biochemical; Biochemical Pathway; Biological Assay; Biological Markers; Brain; Brain imaging; Brain region; Brain-Derived Neurotrophic Factor; Cerebrospinal Fluid; Cerebrovascular Disorders; Cognition; Cognitive; Cognitive aging; Cohort Studies; Communities; Competence; Complement; Data; Dementia; Disease Pathway; Doctor of Philosophy; Educational Curriculum; Elderly; Ensure; Epidemiologist; Epidemiology; Financial Hardship; Funding; Future; Geriatrics; Goals; Health; Healthcare Systems; Hippocampus (Brain); Impaired cognition; Impairment; Incidence; Individual; Insulin-Like Growth Factor I; Intervention; Lead; Life; Life Style; Light; Link; Longitudinal trends; Magnetic Resonance Imaging; Manuscripts; Measurement; Measures; Medicine; Mentors; Methods; Modality; Nerve Degeneration; Neural Pathways; Neurocognitive; Neurodegenerative Disorders; Neurology; Neuronal Plasticity; Neurosciences; North Carolina; Outcome; Parents; Participant; Pathway interactions; Pattern; Phase; Physical activity; Plasma; Population; Population Distributions; Population Sciences; Population Study; Postdoctoral Fellow; Publications; Publishing; Race; Reporting; Research; Research Personnel; Research Training; Risk; Risk Factors; Role; Sampling; Science; Scientist; Specimen; Structure; Supervision; Testing; Training; United States National Institutes of Health; Universities; Visit; Woman; Work; active lifestyle; adjudicate; age related; aging population; base; biracial; brain abnormalities; cardiovascular disorder epidemiology; cardiovascular disorder risk; career; career development; cognitive function; cognitive testing; cohort; cost; cost effective; distinguished professor; epidemiology study; gray matter; imaging biomarker; in vivo imaging; innovation; insight; men; middle age; mild cognitive impairment; modifiable risk; multidisciplinary; neurofilament; neuroimaging; neuropathology; neurotrophic factor; novel; population based; preservation; prevent; professor; programs; prospective; relating to nervous system; research and development; sex; single molecule; skills; tau Proteins; vascular cognitive impairment and dementia

ABSTRACT This is a NIH Pathway to Independence Award (K99/R00) application intended to promote the career of Dr. Priya Palta, PhD, a postdoctoral fellow at the University of North Carolina at Chapel Hill, to a path of independent research. Dr. Palta is a trained epidemiologist with a multidisciplinary record of research in the epidemiology of cardiovascular disease (CVD), aging, and CVD risk factors for cognitive decline and dementia. Her goal is to build on these skills through focused training in neuroscience to become an independent scientist at the interface of neuroscience and population sciences, for innovative work on modifiable targets that influence pathways associated with age-related cognitive decline. The topical areas of the proposed training and subsequent research are physical activity, age-related cognitive decline, neuroimaging, and neurotrophic factors reported to link physical activity with increased neuroplasticity. K99 Career development aim: Obtain transdisciplinary competencies in the biochemical and neural pathways that underlie cognitive function, including neurotrophic biomarkers and neuroimaging modalities through a didactic and experiential curriculum complemented by a novel prospective population-based study. These activities will be supervised by lead mentor Dr. Gerardo Heiss, MD PhD, Kenan Distinguished Professor of Epidemiology and co-mentors Dr. Kelly Evenson, PhD, Research Professor of Epidemiology, and Dr. Thomas Mosley, PhD, Professor of Medicine (Geriatrics) and Neurology. A team of collaborators with complementary expertise will supplement Dr. Palta's training in specific areas. The team of mentors and collaborators is fully committed to assisting Dr. Palta reach her research training and career development goals and to ensure her successful transition to independent researcher. Post-mentored R00 phase: Dr. Palta will apply the K99 competencies to develop an innovative R00 project nested in the cohort of the ongoing Atherosclerosis Risk in Communities (ARIC) Study. For this, physical activity over 23 years and neurotrophic markers (BDNF and IGF-1) measured on the ARIC participants will be related to repeat cognitive assessments, gray matter hippocampal volumes, and adjudicated mild cognitive impairment (MCI) and Alzheimer's disease (AD). Anticipated results: Through this Pathway to Independence Award, Dr. Palta will acquire (1) in-depth multidisciplinary training in the measurement, analysis and interpretation of (a) neurotrophic biomarkers and (b) neuroimaging outcomes for their application in population-based studies and (2) apply these new competencies to an innovative research question on the biochemical and neural links between physical activity and neurocognitive outcomes. This proposal will contribute novel science in the (1) critical assessment of the role of midlife physical activity in delaying cognitive impairment, (2) on the population distribution of BDNF and IGF-1 and its associations with physical activity and neurocognitive outcomes, and (3) targets for community-based lifestyle and physical activity programs to impact cognitive aging.

摘要 这是一个国家卫生研究院途径独立奖（K99/R 00）的应用程序，旨在促进博士的职业生涯。 Priya Palta博士是查佩尔山的北卡罗来纳州大学的博士后研究员， 独立研究。帕尔塔博士是一位训练有素的流行病学家，在流行病学领域拥有多学科的研究记录。 心血管疾病（CVD）流行病学、老龄化和认知能力下降和痴呆的CVD危险因素。 她的目标是通过神经科学的集中培训，在这些技能的基础上，成为一名独立的 神经科学和人口科学界的科学家，在可改变的目标方面的创新工作 影响与年龄相关的认知能力下降的途径。建议的专题领域 训练和随后的研究是身体活动，与年龄有关的认知衰退，神经成像， 据报道，神经营养因子将体力活动与神经可塑性增加联系起来。K99职业发展 目标：获得认知生物化学和神经通路的跨学科能力 功能，包括神经营养生物标志物和神经成像方式，通过教学和经验， 课程由一个新的前瞻性人口为基础的研究补充。这些活动将受到监督 由首席导师Gerardo Heiss博士，医学博士，凯南流行病学杰出教授和共同导师 博士流行病学研究教授Kelly Evenson博士和流行病学教授托马斯莫斯利博士 医学（老年医学）和神经病学。一个具有互补专业知识的合作者团队将补充博士。 帕尔塔在特定领域的培训。导师和合作者团队全力协助Dr. 帕尔塔达到她的研究培训和职业发展目标，并确保她成功过渡到 独立研究员。辅导后R 00阶段：Palta博士将应用K99能力来开发 创新的R 00项目嵌套在正在进行的社区动脉粥样硬化风险（ARIC）研究的队列中。 为此，23年以上的体力活动和ARIC上测量的神经营养标志物（BDNF和IGF-1） 参与者将涉及重复认知评估，灰质海马体积， 判定为轻度认知障碍（MCI）和阿尔茨海默病（AD）。预期成果：通过这一 独立之路奖，帕尔塔博士将获得（1）深入的多学科培训， 测量、分析和解释（a）神经营养生物标志物和（B）神经成像结果， 它们在基于人口的研究中的应用;（2）将这些新能力应用于创新研究 关于身体活动和神经认知结果之间的生物化学和神经联系的问题。这 该提案将在以下方面做出新的科学贡献：（1）对中年体育活动在以下方面的作用进行批判性评估： 延缓认知功能障碍，（2）BDNF和IGF-1的人群分布及其与 身体活动和神经认知结果，以及（3）基于社区的生活方式和身体活动的目标 活动计划来影响认知老化。