Boston Alcohol Research Collaboration on HIV/AIDS - Comorbidity Center (Boston ARCH CC)

波士顿酒精艾滋病毒/艾滋病研究合作 - 合并症中心 (Boston ARCH CC)

• 批准号: 10304666
• 负责人: Michael D Stein
• 金额: $ 149.41万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-22 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10304666
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Affect; Alcohol consumption; Alcohol or Other Drugs use; Alcohols; Behavioral; Biometry; Boston; Cardiovascular Diseases; Caring; Clinical Trials; Collaborations; Communities; Complex; Data; Data Analyses; Drug Use Disorder; Ecological momentary assessment; Ecology; Elderly; Enrollment; Funding; Goals; Grant; HIV; HIV Infections; Health; Health behavior; Heavy Drinking; Home; Infection; Infrastructure; Interdisciplinary Study; Intervention; Investigation; Lead; Life; Life Style; Longevity; Measurement; Mediator of activation protein; Medical; Medicine; Mentors; Methodology; National Institute on Alcohol Abuse and Alcoholism; Osteopenia; Outcome; Pain; Pain Research; Participant; Patients; Persons; Pharmaceutical Preparations; Physical Function; Physical activity; Play; Population; Procedures; Psychology; Public Health; Randomized Controlled Trials; Research; Research Methodology; Research Personnel; Research Project Grants; Risk; Risk Management; Role; Services; Sum; Testing; Translating; United States National Institutes of Health; Visit; Work; addiction; alcohol and other drug; alcohol misuse; alcohol research; alcohol use disorder; antiretroviral therapy; base; chronic pain; chronic painful condition; cohesion; cohort; community setting; comorbidity; data management; drinking; eHealth; efficacy testing; exercise intervention; falls; frailty; functional status; improved; interdisciplinary approach; interest; mental function; multidisciplinary; pandemic disease; physical inactivity; population based; programs; prospective; randomized trial; recruit; secondary analysis; secondary outcome; substance use; trial design

PROJECT SUMMARY/ABSTRACT Effective antiretroviral therapy has increased the lifespan of people living with HIV (PLWH). Alcohol use, common among PLWH, plays an increasingly important role in the risk for and management of HIV-associated comorbidities. Unhealthy drinking can exacerbate two highly prevalent HIV-related comorbidities/co-occurring conditions, chronic pain and physical inactivity, which in turn, can intensify alcohol use and affect physical and mental function in PLWH. We propose the Boston Alcohol Research Collaboration on HIV/AIDS – Comorbidity Center (Boston ARCH CC) as an extension of our Boston Alcohol Research Collaboration on HIV/AIDS (ARCH) cohort launched in 2011 and renewed in 2016 with funding from NIAAA. In Boston ARCH CC we target in randomized trials these two modifiable conditions, pain and physical inactivity, that have a critical impact on a variety of other HIV-related comorbidities. Boston ARCH CC contains 4 integrated components that make unique contributions to our interdisciplinary approach: two randomized trials (Research Project Components), an Administrative Core (AC) that coordinates the P01, and a Biostatistics and Data Management (BDM) Core that supports the trials methodologically and provides data management and biostatistical expertise to them, and continues secondary analyses using extant Boston ARCH data. In Objective 1 we will conduct state-of-the-art e-health clinical trials research on scalable approaches to address the HIV-associated conditions chronic pain and physical inactivity in PLWH with unhealthy alcohol use. By recruiting, assessing, and intervening with participants outside of standard medical visits, through entirely online e-health procedures, our trials address unhealthy drinking in the care of complex HIV patients. In Objective 2 we will support secondary analyses of the existing Boston ARCH cohort, and provide support and mentoring to trainees and investigators accessing the cohort data. The nearly ten- year prospective Boston ARCH cohort enrolled PLWH with current or past substance use, and provides the basis for creating a program for early stage alcohol-HIV investigators interested in scientific questions related to pain, physical inactivity, and physical and mental functioning. To achieve the goal of addressing these two co-occurring conditions, we bring together multidisciplinary experts in fields including alcohol and HIV, public health, addiction medicine, clinical trials, psychology, pain, physical activity, ecological momentary assessment, functional status measurement, and research methods and services (biostatistics and data management). The integration across these fields provides a cohesive program where the whole is bigger than the sum of the parts, supporting investigators whose work can be rapidly translated to community-based population impact.

项目概要/摘要 有效的抗逆转录病毒治疗延长了艾滋病毒感染者（PLWH）的寿命。使用酒精、 艾滋病病毒感染者中常见，在艾滋病毒相关风险和管理中发挥着越来越重要的作用 合并症。不健康饮酒会加剧两种高度流行的艾滋病毒相关合并症/同时发生 状况、慢性疼痛和缺乏身体活动，反过来又会加剧饮酒并影响身体和身体健康。 PLWH 的心理功能。我们提议针对艾滋病毒/艾滋病开展波士顿酒精研究合作—— 合并症中心（波士顿 ARCH CC）作为我们波士顿酒精研究合作的延伸 HIV/AIDS (ARCH) 队列于 2011 年启动，并在 NIAAA 的资助下于 2016 年更新。位于波士顿拱门 CC 我们在随机试验中针对这两种可改变的状况，即疼痛和缺乏身体活动，它们具有 对各种其他与艾滋病毒相关的合并症具有重要影响。 Boston ARCH CC 包含 4 个集成 对我们的跨学科方法做出独特贡献的组成部分：两项随机试验（研究 项目组成部分）、协调 P01 的管理核心 (AC) 以及生物统计和数据 管理 (BDM) 核心，在方法上支持试验并提供数据管理和 向他们提供生物统计学专业知识，并使用现有的波士顿 ARCH 数据继续进行二次分析。在 目标 1 我们将针对可扩展的方法进行最先进的电子健康临床试验研究 解决不健康的艾滋病病毒感染者的慢性疼痛和身体缺乏活动的问题 酒精的使用。通过在标准医疗就诊之外招募、评估和干预参与者， 通过完全在线的电子医疗程序，我们的试验解决了治疗复杂艾滋病毒时的不健康饮酒问题 患者。在目标 2 中，我们将支持对现有 Boston ARCH 队列进行二次分析，并且 为访问队列数据的学员和研究人员提供支持和指导。近十个—— 年前瞻性波士顿 ARCH 队列纳入了当前或过去使用药物的 PLWH，并提供了 为对相关科学问题感兴趣的早期酒精-艾滋病毒研究人员制定计划奠定基础 疼痛、缺乏身体活动以及身心功能。为了达到解决这两个问题的目的 针对同时发生的情况，我们汇集了酒精和艾滋病毒、公共场所等领域的多学科专家 健康、成瘾医学、临床试验、心理学、疼痛、体力活动、生态瞬间 评估、功能状态测量以及研究方法和服务（生物统计和数据） 管理）。这些领域的整合提供了一个有凝聚力的计划，整体大于 各部分的总和，支持调查人员的工作可以迅速转化为基于社区的 人口影响。