Boston Alcohol Research Collaboration on HIV/AIDS - Comorbidity Center (Boston ARCH CC)
波士顿酒精艾滋病毒/艾滋病研究合作 - 合并症中心 (Boston ARCH CC)
基本信息
- 批准号:10304666
- 负责人:
- 金额:$ 149.41万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-22 至 2026-08-31
- 项目状态:未结题
- 来源:
- 关键词:AIDS/HIV problemAcquired Immunodeficiency SyndromeAddressAffectAlcohol consumptionAlcohol or Other Drugs useAlcoholsBehavioralBiometryBostonCardiovascular DiseasesCaringClinical TrialsCollaborationsCommunitiesComplexDataData AnalysesDrug Use DisorderEcological momentary assessmentEcologyElderlyEnrollmentFundingGoalsGrantHIVHIV InfectionsHealthHealth behaviorHeavy DrinkingHomeInfectionInfrastructureInterdisciplinary StudyInterventionInvestigationLeadLifeLife StyleLongevityMeasurementMediator of activation proteinMedicalMedicineMentorsMethodologyNational Institute on Alcohol Abuse and AlcoholismOsteopeniaOutcomePainPain ResearchParticipantPatientsPersonsPharmaceutical PreparationsPhysical FunctionPhysical activityPlayPopulationProceduresPsychologyPublic HealthRandomized Controlled TrialsResearchResearch MethodologyResearch PersonnelResearch Project GrantsRiskRisk ManagementRoleServicesSumTestingTranslatingUnited States National Institutes of HealthVisitWorkaddictionalcohol and other drugalcohol misusealcohol researchalcohol use disorderantiretroviral therapybasechronic painchronic painful conditioncohesioncohortcommunity settingcomorbiditydata managementdrinkingeHealthefficacy testingexercise interventionfallsfrailtyfunctional statusimprovedinterdisciplinary approachinterestmental functionmultidisciplinarypandemic diseasephysical inactivitypopulation basedprogramsprospectiverandomized trialrecruitsecondary analysissecondary outcomesubstance usetrial design
项目摘要
PROJECT SUMMARY/ABSTRACT
Effective antiretroviral therapy has increased the lifespan of people living with HIV (PLWH). Alcohol use,
common among PLWH, plays an increasingly important role in the risk for and management of HIV-associated
comorbidities. Unhealthy drinking can exacerbate two highly prevalent HIV-related comorbidities/co-occurring
conditions, chronic pain and physical inactivity, which in turn, can intensify alcohol use and affect physical and
mental function in PLWH. We propose the Boston Alcohol Research Collaboration on HIV/AIDS –
Comorbidity Center (Boston ARCH CC) as an extension of our Boston Alcohol Research Collaboration on
HIV/AIDS (ARCH) cohort launched in 2011 and renewed in 2016 with funding from NIAAA. In Boston ARCH
CC we target in randomized trials these two modifiable conditions, pain and physical inactivity, that have a
critical impact on a variety of other HIV-related comorbidities. Boston ARCH CC contains 4 integrated
components that make unique contributions to our interdisciplinary approach: two randomized trials (Research
Project Components), an Administrative Core (AC) that coordinates the P01, and a Biostatistics and Data
Management (BDM) Core that supports the trials methodologically and provides data management and
biostatistical expertise to them, and continues secondary analyses using extant Boston ARCH data. In
Objective 1 we will conduct state-of-the-art e-health clinical trials research on scalable approaches to
address the HIV-associated conditions chronic pain and physical inactivity in PLWH with unhealthy
alcohol use. By recruiting, assessing, and intervening with participants outside of standard medical visits,
through entirely online e-health procedures, our trials address unhealthy drinking in the care of complex HIV
patients. In Objective 2 we will support secondary analyses of the existing Boston ARCH cohort, and
provide support and mentoring to trainees and investigators accessing the cohort data. The nearly ten-
year prospective Boston ARCH cohort enrolled PLWH with current or past substance use, and provides the
basis for creating a program for early stage alcohol-HIV investigators interested in scientific questions related
to pain, physical inactivity, and physical and mental functioning. To achieve the goal of addressing these two
co-occurring conditions, we bring together multidisciplinary experts in fields including alcohol and HIV, public
health, addiction medicine, clinical trials, psychology, pain, physical activity, ecological momentary
assessment, functional status measurement, and research methods and services (biostatistics and data
management). The integration across these fields provides a cohesive program where the whole is bigger than
the sum of the parts, supporting investigators whose work can be rapidly translated to community-based
population impact.
项目总结/文摘
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Michael D Stein其他文献
Opioid Overdose Knowledge Among Adolescents and Young Adults.
青少年和年轻人的阿片类药物过量知识。
- DOI:
- 发表时间:
2024 - 期刊:
- 影响因子:26.1
- 作者:
Christina E. Freibott;Noel Vest;Michael D Stein;S. Lipson - 通讯作者:
S. Lipson
Michael D Stein的其他文献
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{{ truncateString('Michael D Stein', 18)}}的其他基金
Optimization and multi-site feasibility of yoga for chronic pain in people in treatment for opioid use disorder
瑜伽治疗阿片类药物使用障碍患者慢性疼痛的优化和多部位可行性
- 批准号:
10356867 - 财政年份:2020
- 资助金额:
$ 149.41万 - 项目类别:
Optimization and multi-site feasibility of yoga for chronic pain in people in treatment for opioid use disorder
瑜伽治疗阿片类药物使用障碍患者慢性疼痛的优化和多部位可行性
- 批准号:
10512837 - 财政年份:2020
- 资助金额:
$ 149.41万 - 项目类别:
Optimization and multi-site feasibility of yoga for chronic pain in people in treatment for opioid use disorder
瑜伽治疗阿片类药物使用障碍患者慢性疼痛的优化和多部位可行性
- 批准号:
10451048 - 财政年份:2020
- 资助金额:
$ 149.41万 - 项目类别:
Optimization and multi-site feasibility of yoga for chronic pain in people in treatment for opioid use disorder
瑜伽治疗阿片类药物使用障碍患者慢性疼痛的优化和多部位可行性
- 批准号:
10586124 - 财政年份:2020
- 资助金额:
$ 149.41万 - 项目类别:
Treating Chronic Pain in Buprenorphine Patients in Primary Care Settings
在初级保健机构中治疗丁丙诺啡患者的慢性疼痛
- 批准号:
10343721 - 财政年份:2019
- 资助金额:
$ 149.41万 - 项目类别:
Treating Chronic Pain in Buprenorphine Patients in Primary Care Settings
在初级保健机构中治疗丁丙诺啡患者的慢性疼痛
- 批准号:
10561600 - 财政年份:2019
- 资助金额:
$ 149.41万 - 项目类别:
Yoga to Treat Chronic Pain in Persons Receiving Opioid Agonist Therapy
瑜伽可治疗接受阿片类激动剂治疗的患者的慢性疼痛
- 批准号:
9319211 - 财政年份:2016
- 资助金额:
$ 149.41万 - 项目类别:
Improving Functioning in HIV Patients with Chronic Pain and Comorbid Depressive Symptoms
改善患有慢性疼痛和共存抑郁症状的艾滋病毒患者的功能
- 批准号:
9138424 - 财政年份:2016
- 资助金额:
$ 149.41万 - 项目类别:
Yoga to Treat Chronic Pain in Persons Receiving Opioid Agonist Therapy
瑜伽可治疗接受阿片类激动剂治疗的患者的慢性疼痛
- 批准号:
9091107 - 财政年份:2016
- 资助金额:
$ 149.41万 - 项目类别:
Improving Functioning in HIV Patients with Chronic Pain and Comorbid Depressive Symptoms
改善患有慢性疼痛和共存抑郁症状的艾滋病毒患者的功能
- 批准号:
9253445 - 财政年份:2016
- 资助金额:
$ 149.41万 - 项目类别:
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