Boston Alcohol Research Collaboration on HIV/AIDS - Comorbidity Center (Boston ARCH CC)

波士顿酒精艾滋病毒/艾滋病研究合作 - 合并症中心 (Boston ARCH CC)

• 批准号: 10304666
• 负责人: Michael D Stein
• 金额: $ 149.41万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-22 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10304666
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Affect; Alcohol consumption; Alcohol or Other Drugs use; Alcohols; Behavioral; Biometry; Boston; Cardiovascular Diseases; Caring; Clinical Trials; Collaborations; Communities; Complex; Data; Data Analyses; Drug Use Disorder; Ecological momentary assessment; Ecology; Elderly; Enrollment; Funding; Goals; Grant; HIV; HIV Infections; Health; Health behavior; Heavy Drinking; Home; Infection; Infrastructure; Interdisciplinary Study; Intervention; Investigation; Lead; Life; Life Style; Longevity; Measurement; Mediator of activation protein; Medical; Medicine; Mentors; Methodology; National Institute on Alcohol Abuse and Alcoholism; Osteopenia; Outcome; Pain; Pain Research; Participant; Patients; Persons; Pharmaceutical Preparations; Physical Function; Physical activity; Play; Population; Procedures; Psychology; Public Health; Randomized Controlled Trials; Research; Research Methodology; Research Personnel; Research Project Grants; Risk; Risk Management; Role; Services; Sum; Testing; Translating; United States National Institutes of Health; Visit; Work; addiction; alcohol and other drug; alcohol misuse; alcohol research; alcohol use disorder; antiretroviral therapy; base; chronic pain; chronic painful condition; cohesion; cohort; community setting; comorbidity; data management; drinking; eHealth; efficacy testing; exercise intervention; falls; frailty; functional status; improved; interdisciplinary approach; interest; mental function; multidisciplinary; pandemic disease; physical inactivity; population based; programs; prospective; randomized trial; recruit; secondary analysis; secondary outcome; substance use; trial design

PROJECT SUMMARY/ABSTRACT Effective antiretroviral therapy has increased the lifespan of people living with HIV (PLWH). Alcohol use, common among PLWH, plays an increasingly important role in the risk for and management of HIV-associated comorbidities. Unhealthy drinking can exacerbate two highly prevalent HIV-related comorbidities/co-occurring conditions, chronic pain and physical inactivity, which in turn, can intensify alcohol use and affect physical and mental function in PLWH. We propose the Boston Alcohol Research Collaboration on HIV/AIDS – Comorbidity Center (Boston ARCH CC) as an extension of our Boston Alcohol Research Collaboration on HIV/AIDS (ARCH) cohort launched in 2011 and renewed in 2016 with funding from NIAAA. In Boston ARCH CC we target in randomized trials these two modifiable conditions, pain and physical inactivity, that have a critical impact on a variety of other HIV-related comorbidities. Boston ARCH CC contains 4 integrated components that make unique contributions to our interdisciplinary approach: two randomized trials (Research Project Components), an Administrative Core (AC) that coordinates the P01, and a Biostatistics and Data Management (BDM) Core that supports the trials methodologically and provides data management and biostatistical expertise to them, and continues secondary analyses using extant Boston ARCH data. In Objective 1 we will conduct state-of-the-art e-health clinical trials research on scalable approaches to address the HIV-associated conditions chronic pain and physical inactivity in PLWH with unhealthy alcohol use. By recruiting, assessing, and intervening with participants outside of standard medical visits, through entirely online e-health procedures, our trials address unhealthy drinking in the care of complex HIV patients. In Objective 2 we will support secondary analyses of the existing Boston ARCH cohort, and provide support and mentoring to trainees and investigators accessing the cohort data. The nearly ten- year prospective Boston ARCH cohort enrolled PLWH with current or past substance use, and provides the basis for creating a program for early stage alcohol-HIV investigators interested in scientific questions related to pain, physical inactivity, and physical and mental functioning. To achieve the goal of addressing these two co-occurring conditions, we bring together multidisciplinary experts in fields including alcohol and HIV, public health, addiction medicine, clinical trials, psychology, pain, physical activity, ecological momentary assessment, functional status measurement, and research methods and services (biostatistics and data management). The integration across these fields provides a cohesive program where the whole is bigger than the sum of the parts, supporting investigators whose work can be rapidly translated to community-based population impact.

项目摘要/摘要 有效的抗逆转录病毒治疗延长了艾滋病毒感染者(PLWH)的寿命。酗酒， 在PLWH中常见，在HIV相关风险和管理中发挥着越来越重要的作用 合并症。不健康的饮酒会加剧两种与艾滋病毒相关的高度流行的共病/共病 病情、慢性疼痛和缺乏体力活动，反过来又会加剧饮酒并影响身体和 PLWH患者的心理功能。我们建议波士顿酒精研究合作研究艾滋病毒/艾滋病- 共病中心(波士顿ARCH CC)作为我们波士顿酒精研究合作的延伸 艾滋病毒/艾滋病(ARCH)队列于2011年启动，并在NIAAA的资助下于2016年更新。在波士顿拱门 CC我们在随机试验中瞄准了这两种可改变的情况，疼痛和缺乏体力活动，它们具有 对其他各种与艾滋病毒相关的合并症的严重影响。波士顿拱门CC包含4个完整的 对我们的跨学科方法做出独特贡献的组件：两个随机试验(研究 项目组成部分)、协调P01的管理核心(AC)以及生物统计和数据 管理(BDM)核心，在方法上支持试验，并提供数据管理和 生物统计学专业知识，并继续使用现有的波士顿ARCH数据进行二次分析。在……里面 目标1我们将进行最先进的电子健康临床试验研究，研究可扩展的方法 应对不健康的PLWH患者的HIV相关疾病、慢性疼痛和缺乏体力活动 酗酒。通过招募、评估和干预标准就诊之外的参与者， 通过完全在线的电子健康程序，我们的试验解决了复杂艾滋病毒护理中不健康的饮酒问题 病人。在目标2中，我们将支持对现有波士顿ARCH队列的二次分析，以及 为访问队列数据的受训者和调查人员提供支持和指导。近十个- 年预期波士顿ARCH队列登记的PLWH目前或过去的药物使用情况，并提供 为对相关科学问题感兴趣的早期酒精-艾滋病毒调查人员创建计划的基础 疼痛，身体缺乏活动，以及身体和精神功能。要实现解决这两个问题的目标 我们汇集了酒精和艾滋病毒等领域的多学科专家，公众 健康、成瘾医学、临床试验、心理学、疼痛、体力活动、生态瞬间 评估、功能状况衡量、研究方法和服务(生物统计和数据 管理)。这些领域的集成提供了一个整体大于 各部分的总和，支持调查人员的工作可以迅速转化为基于社区的工作 对人口的影响。