Improving Functioning in HIV Patients with Chronic Pain and Comorbid Depressive Symptoms

改善患有慢性疼痛和共存抑郁症状的艾滋病毒患者的功能

基本信息

  • 批准号:
    9138424
  • 负责人:
  • 金额:
    $ 49.26万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2016
  • 资助国家:
    美国
  • 起止时间:
    2016-06-01 至 2021-03-31
  • 项目状态:
    已结题

项目摘要

 DESCRIPTION (provided by applicant): Chronic pain is a significant problem for persons living with HIV/AIDS (PLWHAs). Thirty to 65% of patients receiving HIV care have pain that interferes with daily activities. Although pharmacological options to treat pain are often only partially effective, there is little research on non-pharmacological treatments designed to address pain interference with functioning (or other pain outcomes) in PLWHAs. Pain treatment in PLWHAs is further complicated by comorbidities such as depression and substance misuse/ abuse. The co-occurrence of chronic pain and depressive symptoms (highly prevalent among PLWHAs) is associated with increased suffering and disability relative to either problem alone. Both chronic pain and depression increase the risk of non-adherence to antiretroviral treatment. PLWHAs often receive care in primary care settings, and with the growth of the "medical home" for patients with complex chronic illnesses, the coordinated primary care treatment of physical pain and depression may be a good model for long-term HIV care. Funded by a 2-year grant from the National Institute of Nursing Research, we developed a collaborative, psychosocial adjunctive treatment for managing both pain and depression in PLWHAs in primary care. This intervention, entitled HIV-PASS (HIV Pain and Sadness Study), integrates and builds upon behavior therapy for chronic pain and depression. The goal of HIV-PASS is to teach patients skills for reducing behavioral avoidance and increasing engagement in day-to- day valued activities, thereby ultimately improving functional capacity (i.e., both psychosocial and physical functioning) and decreasing depression. HIV-PASS does not directly treat substance misuse/ abuse but involves explicit support for substance abuse treatment as needed. In this preliminary work, we conducted an RCT (n = 23) of HIV-PASS vs. a health education (HE) control group for PLWHAs with chronic pain and elevated depressive symptoms. We established feasibility and acceptability on several metrics, including patient adherence to the treatment protocol and found important between group differences in outcomes. In the current R01 application, we propose to conduct an adequately powered randomized controlled trial of HIV- PASS vs. HE in PLWHAs with chronic pain and elevated depressive symptoms. We will enroll 236 patients, provide interventions over 3 months, and follow patients for a total of 12 months so that we may observe short- term and longer-term effects. We plan to compare HIV-PASS to HE on: 1) the primary outcome variable, interference with physical and psychosocial functioning ("pain interference"), over the 3-month acute treatment phase; 2) secondary outcome variables in the acute treatment phase, including depression, anxiety, physical activity (steps per day, measured with accelerometers), antiretroviral adherence, and viral load; 3) primary and secondary outcome variables over 12 months (i.e., acute treatment phase + a follow-up phase); and 4) cost effectiveness. We will also examine mechanisms by which HIV-PASS may reduce pain interference.


项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Michael D Stein其他文献

Opioid Overdose Knowledge Among Adolescents and Young Adults.
青少年和年轻人的阿片类药物过量知识。
  • DOI:
  • 发表时间:
    2024
  • 期刊:
  • 影响因子:
    26.1
  • 作者:
    Christina E. Freibott;Noel Vest;Michael D Stein;S. Lipson
  • 通讯作者:
    S. Lipson

Michael D Stein的其他文献

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{{ truncateString('Michael D Stein', 18)}}的其他基金

Boston Alcohol Research Collaboration on HIV/AIDS - Comorbidity Center (Boston ARCH CC)
波士顿酒精艾滋病毒/艾滋病研究合作 - 合并症中心 (Boston ARCH CC)
  • 批准号:
    10304666
  • 财政年份:
    2021
  • 资助金额:
    $ 49.26万
  • 项目类别:
Optimization and multi-site feasibility of yoga for chronic pain in people in treatment for opioid use disorder
瑜伽治疗阿片类药物使用障碍患者慢性疼痛的优化和多部位可行性
  • 批准号:
    10356867
  • 财政年份:
    2020
  • 资助金额:
    $ 49.26万
  • 项目类别:
Optimization and multi-site feasibility of yoga for chronic pain in people in treatment for opioid use disorder
瑜伽治疗阿片类药物使用障碍患者慢性疼痛的优化和多部位可行性
  • 批准号:
    10512837
  • 财政年份:
    2020
  • 资助金额:
    $ 49.26万
  • 项目类别:
Optimization and multi-site feasibility of yoga for chronic pain in people in treatment for opioid use disorder
瑜伽治疗阿片类药物使用障碍患者慢性疼痛的优化和多部位可行性
  • 批准号:
    10451048
  • 财政年份:
    2020
  • 资助金额:
    $ 49.26万
  • 项目类别:
Optimization and multi-site feasibility of yoga for chronic pain in people in treatment for opioid use disorder
瑜伽治疗阿片类药物使用障碍患者慢性疼痛的优化和多部位可行性
  • 批准号:
    10586124
  • 财政年份:
    2020
  • 资助金额:
    $ 49.26万
  • 项目类别:
Treating Chronic Pain in Buprenorphine Patients in Primary Care Settings
在初级保健机构中治疗丁丙诺啡患者的慢性疼痛
  • 批准号:
    10343721
  • 财政年份:
    2019
  • 资助金额:
    $ 49.26万
  • 项目类别:
Treating Chronic Pain in Buprenorphine Patients in Primary Care Settings
在初级保健机构中治疗丁丙诺啡患者的慢性疼痛
  • 批准号:
    10561600
  • 财政年份:
    2019
  • 资助金额:
    $ 49.26万
  • 项目类别:
Yoga to Treat Chronic Pain in Persons Receiving Opioid Agonist Therapy
瑜伽可治疗接受阿片类激动剂治疗的患者的慢性疼痛
  • 批准号:
    9319211
  • 财政年份:
    2016
  • 资助金额:
    $ 49.26万
  • 项目类别:
Yoga to Treat Chronic Pain in Persons Receiving Opioid Agonist Therapy
瑜伽可治疗接受阿片类激动剂治疗的患者的慢性疼痛
  • 批准号:
    9091107
  • 财政年份:
    2016
  • 资助金额:
    $ 49.26万
  • 项目类别:
Improving Functioning in HIV Patients with Chronic Pain and Comorbid Depressive Symptoms
改善患有慢性疼痛和共存抑郁症状的艾滋病毒患者的功能
  • 批准号:
    9253445
  • 财政年份:
    2016
  • 资助金额:
    $ 49.26万
  • 项目类别:

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