Administrative Core

行政核心

• 批准号: 10303984
• 负责人: JEFFREY H. SAMET
• 金额: $ 18.22万
• 依托单位: BOSTON MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-10 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10303984
• 关键词: AIDS/HIV problem; Accounting; Address; Affect; Aftercare; Alcohol consumption; Alcohols; Automobile Driving; Biometry; Bone Density; Boston; CD4 Lymphocyte Count; Cause of Death; Cessation of life; Collaborations; Communicable Diseases; Communication; Complex; Data; Data Management Resources; Disease; Ensure; Epidemiology; Fostering; Future; Goals; HIV; HIV Infections; Heavy Drinking; Infectious Agent; Internal Medicine; International; International Aspects; Intervention; Knowledge; Leadership; Location; Lung diseases; Medicine; Mentors; Morbidity - disease rate; NIH Office of AIDS Research; Persons; Preventive treatment; Principal Investigator; Pulmonary Tuberculosis; Pulmonology; Research; Research Personnel; Research Project Grants; Resources; Risk; Risk Factors; Role; Russia; Sampling; Smoking; Statistical Data Interpretation; Time; Training; Tuberculosis; Uganda; United States; Zinc; active method; addiction; alcohol consequences; alcohol intervention; alcohol research; career; co-infection; cohort; comorbidity; data management; data sharing; experience; frailty; inflammatory marker; innovation; mortality; multidisciplinary; next generation; repository; smoking intervention; success; synergism; therapy development; tuberculosis treatment

ABSTRACT Tuberculosis (TB) is the leading cause of death from a single infectious agent worldwide, and accounts for a third of the total number of deaths caused by HIV/AIDS. Understanding the role of alcohol in new TB infection, occurrence of active TB disease, and lung disease after TB treatment in the context of HIV infection is vital to reducing the risks of TB morbidity and mortality among PLWH. The theme of the International Uganda Russia Boston Alcohol Network for Alcohol Research Collaboration on HIV/AIDS (URBAN ARCH) Center is to understand the impact of alcohol on the spectrum of TB infection among PLWH. The International URBAN ARCH Center will continue to build on its experience in establishing and maintaining cohorts of PLWH in Uganda and Russia and will evaluate research questions uniquely addressable in these locations. This global research is aligned with the NIH Office of AIDS Research’s highest priorities for HIV and HIV-related research (i.e., addressing HIV-associated comorbidities, coinfections, and complications). The Administrative (Admin) Core will provide the organizational framework for the International URBAN ARCH Center and will facilitate synergy among the Center’s 4 components: 1) Admin Core; 2) Biostatistics and Data Management (BDM) Core; 3) Russia Project; and 4) Uganda Project. The Admin Core will be responsible for day-to-day management and functioning of the Center with the goal of ensuring that the scientific and programmatic activities of the Center are integrated and carried out with high quality and timeliness. The Admin Core will accomplish the following Specific Aims: 1) Promote a collaborative, synergistic approach to research goals; 2) Facilitate communication, integration, and collaboration between all Center components; 3) Coordinate access to resources including the International URBAN ARCH Center data and sample repository; 4) Assess and foster components’ progress and quality to maximize the scientific impact of the Center; 5) Encourage the sharing of data with investigators within the Center and beyond; and 6) Develop future leadership of the Center and the next generation of HIV/alcohol researchers. Under the leadership of the Admin Core and with its expert facilitation and research management, the International URBAN ARCH Center will generate new generalizable knowledge about the complex relationship between TB, HIV, and alcohol use in order to accelerate the future development of interventions that can reduce alcohol’s impact on TB-related morbidity and mortality among PLWH. The success of the International URBAN ARCH Center is critically dependent on the Admin Core’s scientific and administrative leadership to ensure that all components function optimally and synergistically.

抽象的 结核病（TB）是全世界单一传染毒剂死亡的主要原因，并说明了 艾滋病毒/艾滋病造成的死亡总数的三分之一。了解酒精在新结核病感染中的作用， 在HIV感染的情况下，发生活性结核病疾病和结核病治疗后的肺疾病对于 降低了PLWH中结核病发病率和死亡率的风险。国际乌干达俄罗斯的主题 波士顿酒精酒精网络研究艾滋病毒/艾滋病（Urban Arch）中心的合作是 了解酒精对PLWH中结核病感染范围的影响。国际城市 拱门中心将继续基于建立和维护PLWH的经验 乌干达和俄罗斯将在这些地点评估可独特解决的研究问题。这个全球 研究与NIH AIDS Research办公室对HIV和与HIV相关的研究的最高优先事项保持一致 （即，解决与HIV相关的合并症，共同感染和并发症）。行政（管理员） 核心将为国际城市拱门中心提供组织框架，并将最喜欢 中心4个组件之间的协同作用：1）管理员核心； 2）生物统计学和数据管理（BDM） 核; 3）俄罗斯项目； 4）乌干达项目。管理员核心将负责日常 中心的管理和运作，目的是确保科学和程序化 该中心的活动以高质量和及时性进行整合和进行。管理员核心将 完成以下具体目的：1）促进一种协作，协同的研究目标； 2） 促进所有中心组件之间的沟通，集成和协作； 3）协调访问 到包括国际城市拱门中心数据和样本存储库在内的资源； 4）评估和 促进组件的进步和质量，以最大程度地发挥中心的科学影响； 5）鼓励 与中心内及以后的调查人员共享数据； 6）发展该中心的未来领导 以及下一代艾滋病毒/酒精研究人员。在管理员核心的领导下及其专家 促进与研究管理，国际城市拱门中心将产生新的可推广 有关结核病，艾滋病毒和酒精使用之间复杂关系的知识，以加速未来 开发干预措施，可以减少酒精对与结核病相关的发病率和死亡率的影响 plwh。国际城市拱门中心的成功取决于管理员核心 科学和行政领导，以确保所有组件在最佳和协同上发挥作用。