URBAN ARCH (1/5) Administrative Coordinating Core (Admin Core)

项目摘要 由于艾滋病毒治疗的改善和获得抗逆转录病毒治疗的机会，艾滋病毒感染者的生活 更长，这导致了合并症的增加。不健康的酒精使用在这一人群中很普遍 并与多种不良健康状况的风险增加和结局恶化相关，包括 肺结核[TB]、心血管疾病[CVD]和福尔斯。在过去的5年里，乌干达俄罗斯波士顿 酒精网络艾滋病毒/艾滋病研究合作联盟成立 研究人员对艾滋病毒感染者的队列进行了研究，并调查了饮酒与艾滋病毒之间的复杂关系。 通过国内和国际合作，URBAN ARCH研究人员，包括专家， 流行病学，内科，成瘾医学，艾滋病毒/艾滋病，传染病，精神病学，和 生物统计学，重点关注酒精使用如何影响艾滋病毒的临床表现，以及如何治疗超越 ART减轻酒精相关危害。未来5年城市规划联盟的中心主题 研究酒精使用对艾滋病毒感染者合并症的影响， 增加治疗的可用性并改善结果。 URBAN将在乌干达、俄罗斯和波士顿现有的艾滋病毒感染者队列的基础上， 他们的良好特征的酒精消费模式，开始重要的新的研究举措。这 全球研究与艾滋病研究办公室的最高艾滋病毒/艾滋病研究优先事项（即， 预防和治疗艾滋病毒相关的合并症和并发症，包括结核病[乌干达]、心血管疾病 [俄罗斯]和福尔斯[波士顿]）。行政核心的目标是确保科学和 城市规划联合会的方案活动以高质量和及时的方式开展。的 行政核心将使用最新的技术，以最大限度地提高城市规划的整体生产力。 联合并协助促进多学科合作，以促进创新和严格的 艾滋病毒/酒精研究以下是行政核心的具体目标： * 促进对研究目标采取合作和综合的办法; * 促进联盟各组成部分之间的沟通和协作; * 协调和优先利用资源，包括URBAN数据库和样本储存库; 评估各组成部分的进展和质量，以最大限度地发挥联合会的科学影响; 鼓励与联盟内外的研究者共享数据。 城市规划的成功将主要取决于行政核心的科学和 行政领导，以整合和利用联盟的优秀合作者，资源， 群体和研究能力。

Project Summary Due to improved HIV treatment and access to antiretroviral therapy (ART), people living with HIV are living longer, which has resulted in an increase in comorbidities. Unhealthy alcohol use is prevalent in this population and is associated with increased risk and worse outcomes for multiple adverse health conditions, including tuberculosis [TB], cardiovascular disease [CVD], and falls. Over the past 5 years, the Uganda Russia Boston Alcohol Network for Alcohol Research Collaboration on HIV/AIDS (URBAN ARCH) Consortium created cohorts of people living with HIV and investigated the complex relationship between alcohol use and HIV. Through domestic and international collaborations, URBAN ARCH investigators, including specialists in epidemiology, internal medicine, addiction medicine, HIV/AIDS, infectious diseases, psychiatry, and biostatistics, have focused on how alcohol use affects HIV clinical manifestations and how treatments beyond ART mitigate alcohol-related harms. The central theme of the URBAN ARCH Consortium for the next 5 years is to examine the consequences of alcohol use on comorbidities among people living with HIV so as to increase availability of treatments and improve outcomes. URBAN ARCH will build upon existing cohorts of people living with HIV in Uganda, Russia, and Boston with their well-characterized alcohol consumption patterns to embark on important new research initiatives. This global research is aligned with the Office of AIDS Research's highest HIV/AIDS research priorities (i.e., prevention and treatment of HIV-related comorbidities and complications, including TB [Uganda], CVD [Russia], and falls [Boston]).The goal of the Administrative Core is to ensure that the scientific and programmatic activities of the URBAN ARCH Consortium are carried out with high quality and timeliness. The Administrative Core will use the latest technologies to maximize the overall productivity of the URBAN ARCH Consortium and assist with the fostering of multidisciplinary collaborations to promote innovative and rigorous HIV/alcohol research. The following are the Specific Aims of the Administrative Core:  Promote a collaborative, integrated approach to research goals;  Facilitate communication and collaboration between all Consortium components;  Coordinate and prioritize access to resources including the URBAN ARCH data and sample repository;  Assess components' progress and quality to maximize the scientific impact of the Consortium; and  Encourage the sharing of data with investigators within and outside the Consortium. The success of URBAN ARCH will be critically dependent on the Administrative Core's scientific and administrative leadership to integrate and capitalize on the Consortium's outstanding collaborators, resources, cohorts and research capabilities.