Cognitive and Inflammation Targeted Gut-Brain Interventions in People Living with HIV who are High-Risk Alcohol Users
对高危饮酒者艾滋病毒感染者进行认知和炎症针对性肠脑干预
基本信息
- 批准号:10304326
- 负责人:
- 金额:$ 40.3万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-10 至 2026-08-31
- 项目状态:未结题
- 来源:
- 关键词:Activities of Daily LivingAddressAlcohol consumptionAlcoholsAnti-CholinergicsAnti-Inflammatory AgentsBacteriaBiologicalBiological MarkersBloodBrainCardiovascular systemCognitionCognitiveDataData Science CoreEnrollmentEvaluationFunctional Magnetic Resonance ImagingFunctional disorderGlutathioneGoalsHIVHIV InfectionsHealthHeavy DrinkingHepatitisHomeostasisHumanHybridsImpaired cognitionImpairmentInflammationInflammatoryInterventionIntervention StudiesIntestinal permeabilityLinkLiquid substanceLiver diseasesMachine LearningMeasuresNerveNeurocognitionNeurocognitiveObesityOutcomeParasympathetic Nervous SystemParticipantPathogenicityPathologicPathway interactionsPeripheralPersonsPhasePlacebosPostdoctoral FellowPrevalenceProbioticsProcessPropertyPublic HealthQuality of lifeRandomizedRandomized Clinical TrialsResearchResearch InfrastructureResearch PersonnelRestRisk BehaviorsSerumSystemTestingTherapeuticTherapeutic EffectTraining ProgramsUnited States National Institutes of HealthVagus nerve structureViral Load resultacceptability and feasibilityalcohol effectalcohol researchalcohol riskantiretroviral therapybiological adaptation to stressbrain dysfunctionbrain healthcell motilityclinically significantco-infectioncognitive functioncognitive testingcomorbiditycytokinedesigndysbiosiseffective interventionfecal microbiomefunctional improvementgamma-Aminobutyric Acidgastrointestinalgut dysbiosisgut microbiomegut-brain axishigh riskhigh risk sexual behaviorimmune functionimprovedindexingmicrobialmicrobiome compositionmicrobiota-gut-brain axismortalityneural networkneuroimagingneuroinflammationpre-doctoralprobiotic supplementationreconstitutionrelating to nervous systemscale upsystemic inflammatory responsetransmission processtreatment adherencevagus nerve stimulationviral transmission
项目摘要
RC2 Summary
The overarching goal of Research Component 2 (RC2) is to determine whether two non-invasive biological
interventions, transcutaneous vagal nerve stimulation (tVNS) and a probiotic supplementation intervention (PBI), will
improve cognitive and brain functioning, systemic and neuroinflammation, and gut microbiome health in people living
with HIV (PWLH) who are high risk users of alcohol. The study will also delineate mechanisms of the gut-brain axis, which
is particularly relevant, given that the factors underlying adverse cognitive and brain effects of alcohol use among PLWH
remains unresolved. There is also considerable public health significance if beneficial effects of tVNS and/or PBI can be
demonstrated, as cognitive disturbances that adversely impact health outcomes, functional abilities and quality of life
are common (~ 50% prevalence), despite marked reductions in mortality in the era of antiretroviral therapies (ART).
Among PLWH with reconstituted immune function and undetectable viral loads, comorbid conditions remain common
and can have adverse functional consequences. High risk alcohol use, prevalent among PLWH, not only contributes to
cognitive and brain dysfunction, but also further exacerbates comorbidities (e.g. liver disease, hepatitis coinfection,
obesity, and cardiovascular and gastrointestinal dysfunction), and reduces treatment adherence while increasing the
propensity for high risk sexual behaviors, worse health outcomes, and transmission of the virus. The study’s clinical
significance is strong given the need for effective interventions to improve cognition and health outcomes in PLWH.
To test these hypotheses, we will conduct a hybrid randomized clinical trial that will enroll 80 PLWH who are high
risk drinkers from our existing research infrastructure supported by the Southern HIV Alcohol Research Consortium
(SHARC). In a 2x2 factorial design, participants will be randomly assigned to one of 4 conditions (tVNS+placebo, sham-
stimulaiton+placebo, tVNS+probiotic, sham-stimulation+probiotic). We will obtain data on alcohol consumption,
cognitive assessments, blood biomarkers, stool microbiome, and neuroimaging at three timepoints (baseline, 30-days,
90 days).
RC2总结
项目成果
期刊论文数量(0)
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Eric Porges其他文献
Eric Porges的其他文献
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{{ truncateString('Eric Porges', 18)}}的其他基金
Cognitive and Inflammation Targeted Gut-Brain Interventions in People Living with HIV who are High-Risk Alcohol Users
对高危饮酒者艾滋病毒感染者进行认知和炎症针对性肠脑干预
- 批准号:
10682459 - 财政年份:2021
- 资助金额:
$ 40.3万 - 项目类别:
Cognitive and functional deficits associated with reduced cortical GABA in HIV-infected heavy drinkers
HIV 感染的重度饮酒者中与皮质 GABA 减少相关的认知和功能缺陷
- 批准号:
10221457 - 财政年份:2017
- 资助金额:
$ 40.3万 - 项目类别:
Cognitive and functional deficits associated with reduced cortical GABA in HIV-infected heavy drinkers
HIV 感染的重度饮酒者中与皮质 GABA 减少相关的认知和功能缺陷
- 批准号:
9753836 - 财政年份:2017
- 资助金额:
$ 40.3万 - 项目类别:
Cognitive and functional deficits associated with reduced cortical GABA in HIV-infected heavy drinkers
HIV 感染的重度饮酒者中与皮质 GABA 减少相关的认知和功能缺陷
- 批准号:
9532039 - 财政年份:2017
- 资助金额:
$ 40.3万 - 项目类别:
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