Case Western Reserve University StrokeNet Regional Coordinating Center

凯斯西储大学 StrokeNet 区域协调中心

• 批准号: 10306039
• 负责人: SOPHIA SUNDARARAJAN
• 金额: $ 30.94万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10306039
• 关键词: Academic Medical Centers; Accident and Emergency department; Acute; Adult; Air; Award; Biotechnology; Caring; Child; Clinic; Clinical; Clinical Sciences; Clinical Trials; Clinical Trials Design; Clinical Trials Unit; Collaborations; Communities; Country; County Hospitals; Critical Care; Data; Engineering; Enrollment; Ensure; Ethnic Origin; Fostering; Funding; Grant; Great Lakes Region; Healthcare Systems; Hospitals; Image; Individual; International; Intervention; Lead; Leadership; Medical center; Mentors; Mentorship; Michigan; Monitor; Neurology; Nurses; Participant; Physicians; Population; Positioning Attribute; Prevention; Race; Recording of previous events; Recovery; Rehabilitation therapy; Research; Research Personnel; Resources; Role; Route; Running; Rural; Scientist; Site; Stroke; Structure; System; Training; Translational Research; Transportation; United States Department of Veterans Affairs; United States National Institutes of Health; Universities; University Hospitals; Urban Community; West Virginia; Work; acute care; acute stroke; functional electrical stimulation; neurosurgery; novel therapeutics; organizational structure; patient population; programs; screening; sex; stroke clinical trials; stroke patient; stroke trials; study population

Cleveland is an urban community with several healthcare systems, internationally renowned researchers and a rich history of cooperation with respect to stroke care. University Hospitals of Cleveland (University Hospitals), The Cleveland Clinic, MetroHealth and the Louis Stokes Cleveland VA Medical Center (Cleveland VA) are affliated with Case Western Reserve University (CWRU) and collaborate in a Clinical Translational Science Collaborative (CTSC- funded by a CTSA) to enhance training, research, and discovery in Cleveland. In 2013 we were awarded a Regional Coordinating Center (RCC) as part of NIH StrokeNet. This application is to to renew that grant. We have expanded our RCC adding sites in Toledo (Mercy St Vincent Medical Center or Mercy St Vincent), Columbus (OhioHealth), Grand Rapids, Michigan (SpectrumHealth) and Morgantown, WV (West Virginial University (WVU). The inclusion of one county hospital with a large emergency department, VA hospital, and two urban academic medical centers, one academic medical center in a rural state ensures a diverse patient and study population. Our RCC has excellent participation and quality metrics on StrokeNet studies, including the highest enrollment in StrokeNet study in the Great Lakes Region. We have a diverse research community, with clinical researchers, basic scientists, engineers and biotech companies, to collaborate with and bring new projects to the network. We have large hospitals systems, including 3 hospitals ranked in the top 50 Neurology and Neurosurgery programs in the country, 6 Comprehensive Stroke Centers and a seventh site that will be reviewed for Comprehensive designation in October 2017. We have state of the art transportation resources including critical care air transport with physicians and nurse practicioners on board and 2 hospital systems with mobile stroke units that administer thrombolytics in the field or en route to the hospital. We have special expertise in penumbral imaging, acute endovascular therapy and rehabilitation and functional electrical stimulation. We propose a multi-teired leadership. Dr Sophia Sundararajan and Dr. Ken Uchino will lead the RCC as PIs, and representatives from each of the eight hospitals will serve on the Executive committee with the PIs, as will a Project Manager and Training Director. The Executive Committee includes senior and more junior investigators and will oversee and run all aspects of the RCC, but also provide mentorship for more junior investigators. Our leadership succession plan has already successfully mentored Drs Sundararajan and Uchino who will assume the Co-PI roles of this application. With the expertise and resources detailed in this application, the Case Western Reserve University RCC will be well positioned to enhance the structure and organization of our RCC and further accelerate participation in clinical trials for stroke acute intervention, prevention and rehabilitation in both adults and children.

克利夫兰是一个拥有多个医疗保健系统的城市社区，国际知名研究人员 以及在中风护理方面的丰富合作历史。克利夫兰大学医院（University Hospitals of Cleveland） 医院），克利夫兰诊所，MetroHealth和路易斯斯托克斯克利夫兰退伍军人医疗中心 （弗吉尼亚州克利夫兰）与凯斯西储大学（CWRU）有联系，并在临床方面进行合作 翻译科学合作（CTSC-由CTSA资助），以加强培训，研究和 克利夫兰的发现2013年，我们被授予区域协调中心（RCC），作为NIH的一部分 中风网。这份申请是为了更新那份补助金。我们已经扩大了我们的RCC添加网站在托莱多 （Mercy St Vincent Medical Center或Mercy St Vincent），哥伦布（OhioHealth），大急流城，密歇根州 （SpectrumHealth）和Morgantown，WV（West Mineral University（WVU））。一个县的加入 医院有一个大型急诊科，VA医院，和两个城市学术医疗中心，一个 农村州的学术医疗中心确保了患者和研究人群的多样性。 我们的RCC在StrokeNet研究中具有出色的参与和质量指标，包括最高的 在五大湖地区的StrokeNet研究中招募。我们有一个多元化的研究社区， 临床研究人员，基础科学家，工程师和生物技术公司，合作，并带来新的 项目到网络。我们拥有大型医院系统，其中3家医院排名前50位 全国的神经病学和神经外科项目，6个综合中风中心和第七个站点 将于2017年10月进行全面评估。我们有最先进的 交通资源，包括重症监护航空运输，船上有医生和护士执业者 和2个医院系统，配备移动的卒中单元，在现场或前往 医院我们在半暗带成像、急性血管内治疗和康复方面具有特殊专长 和功能性电刺激。我们建议多层次的领导。Sophia Sundararajan博士和Dr. Ken Uchino将作为PI领导RCC，来自八家医院的代表将在 执行委员会与PI，将项目经理和培训总监。执行 委员会包括高级和初级调查员，将监督和管理RCC的各个方面， 同时也为初级调查员提供指导。我们的领导人继任计划已经 成功指导了Sundararajan博士和Uchino博士，他们将担任该应用程序的共同主要研究者。 凭借本申请中详细介绍的专业知识和资源，凯斯西储大学RCC将 做好准备，加强我们区域合作委员会的结构和组织，进一步加快参与 在成人和儿童中风急性干预、预防和康复的临床试验中。