Case Western Reserve University StrokeNet Regional Coordinating Center

克利夫兰是一个拥有几个医疗保健系统的城市社区，国际知名研究人员说 在中风护理方面有着丰富的合作历史。克利夫兰大学医院(大学 医院)、克利夫兰诊所、MetroHealth和Louis Stokes克利夫兰退伍军人医疗中心 (克利夫兰退伍军人事务部)与凯斯西储大学(CWRU)建立联系，并在临床上合作 翻译科学合作(CTSC-由CTSA资助)，以加强培训、研究和 在克利夫兰的发现。2013年，我们被授予区域协调中心(RCC)，作为NIH的一部分 StrokeNet。这项申请是为了续期该赠款。我们已经扩大了我们的RCC在托莱多的添加站点 (仁慈圣文森特医疗中心或仁慈圣文森特)，哥伦布(俄亥俄州健康)，大急流城，密歇根州 (SpectrumHealth)和西弗吉尼亚州摩根敦(西维吉尼亚大学(WVU)。一个县的纳入 有一个大型急诊科的医院，退伍军人医院和两个城市学术医疗中心，一个 农村州的学术医疗中心确保了多样化的患者和研究人群。 我们的RCC在StrokeNet研究中拥有出色的参与度和质量指标，包括最高 在大湖区参加StrokeNet学习。我们有一个多样化的研究社区， 临床研究人员、基础科学家、工程师和生物技术公司，与他们合作并带来新的 向网络投放项目。我们有大型医院系统，其中3家医院排在前50名 全国神经病学和神经外科项目，6个综合中风中心和7个站点 将于2017年10月对其进行全面指定审查。我们有最先进的 运输资源，包括有医生和护士在船上的重症监护空运 和2个带有移动卒中单元的医院系统，用于在现场或送往医院的途中进行溶栓 医院。我们在半影区成像、急性血管内治疗和康复方面拥有特殊的专业知识。 和功能性电刺激。我们建议建立一个多团队的领导层。Sophia Sundararajan博士和Dr。 Ken Uchino将作为PIs领导RCC，来自八家医院的代表将在 与绩效指标组成的执行委员会以及一名项目经理和培训主任。高管们 委员会包括高级和初级调查人员，并将监督和管理RCC的所有方面， 而且还为更初级的调查人员提供指导。我们的领导层接班计划已经 成功地指导了Sundararajan和Uchino博士，他们将担任本应用程序的共同PI角色。 凭借本申请中详细介绍的专业知识和资源，Case Western Reserve University RCC将 做好准备，加强我们RCC的结构和组织，进一步加快参与 在成人和儿童中风急性干预、预防和康复的临床试验中。

Cleveland is an urban community with several healthcare systems, internationally renowned researchers and a rich history of cooperation with respect to stroke care. University Hospitals of Cleveland (University Hospitals), The Cleveland Clinic, MetroHealth and the Louis Stokes Cleveland VA Medical Center (Cleveland VA) are affliated with Case Western Reserve University (CWRU) and collaborate in a Clinical Translational Science Collaborative (CTSC- funded by a CTSA) to enhance training, research, and discovery in Cleveland. In 2013 we were awarded a Regional Coordinating Center (RCC) as part of NIH StrokeNet. This application is to to renew that grant. We have expanded our RCC adding sites in Toledo (Mercy St Vincent Medical Center or Mercy St Vincent), Columbus (OhioHealth), Grand Rapids, Michigan (SpectrumHealth) and Morgantown, WV (West Virginial University (WVU). The inclusion of one county hospital with a large emergency department, VA hospital, and two urban academic medical centers, one academic medical center in a rural state ensures a diverse patient and study population. Our RCC has excellent participation and quality metrics on StrokeNet studies, including the highest enrollment in StrokeNet study in the Great Lakes Region. We have a diverse research community, with clinical researchers, basic scientists, engineers and biotech companies, to collaborate with and bring new projects to the network. We have large hospitals systems, including 3 hospitals ranked in the top 50 Neurology and Neurosurgery programs in the country, 6 Comprehensive Stroke Centers and a seventh site that will be reviewed for Comprehensive designation in October 2017. We have state of the art transportation resources including critical care air transport with physicians and nurse practicioners on board and 2 hospital systems with mobile stroke units that administer thrombolytics in the field or en route to the hospital. We have special expertise in penumbral imaging, acute endovascular therapy and rehabilitation and functional electrical stimulation. We propose a multi-teired leadership. Dr Sophia Sundararajan and Dr. Ken Uchino will lead the RCC as PIs, and representatives from each of the eight hospitals will serve on the Executive committee with the PIs, as will a Project Manager and Training Director. The Executive Committee includes senior and more junior investigators and will oversee and run all aspects of the RCC, but also provide mentorship for more junior investigators. Our leadership succession plan has already successfully mentored Drs Sundararajan and Uchino who will assume the Co-PI roles of this application. With the expertise and resources detailed in this application, the Case Western Reserve University RCC will be well positioned to enhance the structure and organization of our RCC and further accelerate participation in clinical trials for stroke acute intervention, prevention and rehabilitation in both adults and children.