New England Regional Coordinating Center for the NINDS Stroke Trials Network

NINDS 卒中试验网络新英格兰地区协调中心

基本信息

批准号：
10306037
负责人：
Lee H Schwamm
金额：
$ 34.14万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-01 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10306037
关键词：
Achievement Acute Address Adult Advocacy American Heart Association Area Blood Vessels Boston Caring Child Childhood Clinical Clinical Investigator Clinical Research Clinical Trials Clinical Trials Network Clinical and Translational Science Awards Collaborations Community Hospitals Complement Discipline Discipline of Nursing Educational Activities Emergency Medicine Enrollment Environment Faculty Funding Future General Hospitals Goals Health Hospitals Infrastructure Inpatients Institution International Investigation Israel Lead Leadership Letters Maine Massachusetts Medical Medical center Mission Multicenter Trials National Institute of Neurological Disorders and Stroke Neurologist Neurology New England Operative Surgical Procedures Patient Care Patient-Focused Outcomes Patients Pediatric Hospitals Pediatrics Performance Phase Physicians Population Heterogeneity Populations at Risk Positioning Attribute Principal Investigator Protocols documentation Public Health Recording of previous events Records Recovery Recurrence Rehabilitation therapy Research Research Activity Research Infrastructure Research Institute Research Personnel Research Training Resources Role Rural Hospitals Science Seasons Site Stroke Stroke prevention StrokeNet clinical trials Study Section Talents Testing Therapeutic Training Training and Infrastructure Translating Translational Research United States National Institutes of Health Universities Vision Woman acute care base design early phase clinical trial early phase trial experience falls improved improved outcome innovation medical specialties member metropolitan multidisciplinary network models neuroimaging neurosurgery next generation novel novel therapeutics patient population phase III trial pre-clinical programs recruit research study skills stroke clinical trials stroke neurology stroke rehabilitation stroke risk stroke trials success telestroke

项目摘要

We propose to continue the New England Regional Coordinating Center (NERCC), an integrated team of hospitals and EMS agencies in Boston and Western Massachusetts that will serve as a top-enrolling site and vibrant contributor to the NINDS Stroke Trials Network. Our group includes many of the major adult academic stroke centers in the Greater Boston area, and our 30+ hospital New England TeleStroke referral network will extend our potential recruitment even further. All core hospitals have a proven track record of successful management and performance of clinical trials. In particular, all hospitals have an established research infrastructure that performs ongoing clinical research in stroke neurology with strong collaborations across disciplines. Principal investigator Lee H. Schwamm, MD, and Co-Investigators bring a complementary set of skills in managing successful translational clinical research programs, membership on Steering Committees, and positions of national leadership in their fields. Our team includes seasoned clinical investigators in vascular neurology, emergency medicine, neuroendovascular, neurosurgery, neurointensive care, neuroimaging, stroke rehabilitation, and preclinical basic and translational stroke investigation in both adults and children. Strengths of the NERCC team include 1) close personal and professional ties between multiple investigators; 2) large patient population from diverse hospital settings in a major metropolitan area; 3) talented teams of site investigators with track records of scientific achievement, innovation, and subject recruitment in multicenter trials; 4) robust existing NINDS-funded research and clinical trial management infrastructure; 5) existing clinical research programs, e.g., Neurology Clinical Research Institute, NIH Clinical and Translational Science Award programs at Boston University and across Harvard; Sites in the SIREN and NeuroNEXT Clinical Coordinating Center. Overall, the NERCC Team has demonstrated outstanding commitment and performance in the first StrokeNet cycle, and has the resources, vision, and enthusiasm to continue to develop new translational science and successfully execute the NINDS StrokeNet Phase 1,2 and 3 trials.

我们建议继续新英格兰地区协调中心（NERCC），这是一个综合团队波士顿和马萨诸塞州西部的医院和EMS机构将充当顶级入围场所， NINDS中风试验网络的生动贡献者。我们的小组包括许多主要的成人学者大波士顿地区的中风中心和我们30多个医院的新英格兰telestroke推荐网络将进一步扩展我们的潜在招聘。所有核心医院都有成功的成功记录临床试验的管理和性能。特别是所有医院都有一项既定的研究在中风神经病学领域进行持续的临床研究的基础设施，并在跨越强大的合作学科。首席研究员Lee H. Schwamm，医学博士和共同研究员带来了一组补充的管理成功翻译临床研究计划的技能，转向委员会的会员资格，以及国家领导地位在其领域的职位。我们的团队包括经验丰富的血管临床调查人员神经病学，急诊医学，神经内血管，神经外科手术，神经性护理，神经影像学，中风成人和儿童的康复以及临床前的基本和转化中风调查。优势 NERCC团队包括1）多个调查人员之间的个人和专业关系； 2）大来自主要大都市地区各种医院环境的患者人数； 3）现场才华横溢的团队具有科学成就，创新和受试者招聘的科学成就记录的调查员试验； 4）强大的现有NINDS资助的研究和临床试验管理基础设施； 5）现有的临床研究计划，例如神经病学临床研究所，NIH临床和转化科学奖波士顿大学和哈佛大学的课程；警笛和Neuronext临床协调中的站点中心。总体而言，NERCC团队在第一个方面表现出了出色的承诺和表现 Strokenet周期，并具有继续发展新翻译的资源，愿景和热情科学并成功执行Ninds Strokenet阶段1,2和3次试验。