New England Regional Coordinating Center for the NINDS Stroke Trials Network

NINDS 卒中试验网络新英格兰地区协调中心

• 批准号: 9343382
• 负责人: Lee H Schwamm
• 金额: $ 13.73万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-10-01 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9343382
• 关键词: Academic Medical Centers; Achievement; Acute; Address; Adult; Advocacy; Agreement; Ally; American Heart Association; Area; Award; Blood Vessels; Boston; Caring; Child; Clinical; Clinical Investigator; Clinical Research; Clinical Sciences; Clinical Trials; Clinical Trials Network; Collaborations; Community Hospitals; Data; Discipline; Discipline of Nursing; Educational Activities; Emergency Medicine; Emergency treatment; Enrollment; Environment; Faculty; Failure; Funding; Future; General Hospitals; Goals; Health; Hospitals; Inpatients; Institution; Institutional Review Boards; Instruction; International; Investigation; Israel; Lead; Leadership; Letters; Massachusetts; Medical; Medical center; Mission; Modeling; Multicenter Trials; National Institute of Neurological Disorders and Stroke; Neurologist; Neurology; Neurosciences Research; New England; Operative Surgical Procedures; Patient Care; Patient-Focused Outcomes; Patients; Pediatric Hospitals; Performance; Phase; Phase III Clinical Trials; Physicians; Population Heterogeneity; Populations at Risk; Positioning Attribute; Pre-hospitalization care; Principal Investigator; Protocols documentation; Public Health; Recording of previous events; Records; Recovery; Recurrence; Rehabilitation therapy; Research; Research Activity; Research Infrastructure; Research Institute; Research Personnel; Research Training; Resources; Risk; Role; Rural Hospitals; Science; Seasons; Services; Site; Stroke; Stroke prevention; Therapeutic; Training; Training and Infrastructure; Translating; Translational Research; United States National Institutes of Health; Universities; University Hospitals; Vision; Woman; acute stroke; base; experience; improved; improved outcome; innovation; member; metropolitan; multidisciplinary; network models; neuroimaging; neurosurgery; next generation; novel; novel therapeutics; operation; patient population; pre-clinical; programs; research study; skills; stroke intervention; stroke rehabilitation; success; treatment trial

We propose to create the New England Regional Coordinating Center (NERCC), an integrated team of hospitals and EMS agencies in Boston and Western Massachusetts that will serve as a top-enrolling site and vibrant contributor to the NINDS Stroke Trials Network. Our group includes many ofthe major adult academic stroke centers in the Greater Boston area, and our 30 hospital New England TeleStroke referral network will extend our potential recruitment even further. Ail core hospitals have a proven track record of successful management and performance ofclinical trials. In particular, ali hospitals have an established research infrastructure that performs ongoing clinical research in stroke neurology with strong collaborations across disciplines. Principal investigator Lee H. Schwamm, MD, and Co-Investigators bring a complementary set of skills in managing successful translational clinical research programs, membership on Steering Committees, and positions of national leadership in their fields. Our team includes seasoned clinical investigators in vascular neurology, emergency medicine, neuroendovascular, neurosurgery, neurointensive care, neuroimaging, stroke rehabilitation, and preclinical basic and translational stroke investigation in both adults and children. Strengths ofthe NERCC team include 1) close personal and professional ties between multiple investigators; 2) large patient population from diverse hospital settings in a major metropolitan area; 3) talented teams of site investigators with track records of scientific achievement, innovation, and subject recruitment in multicenter trials; 4) robust existing NINDS-funded research and clinical trial management infrastructure; 5) existing clinical research programs, e.g.. Neurology Clinical Research Institute, NIH Clinical and Translational Science Award programs at Boston University and across Harvard; Sites in the Specialized Programs of Translational Research in Acute Stroke (SPOTRIAS) and Neurology Emergency Treatment Trials and NeuroNEXT Clinical Coordinating Center. In addition, integration with Boston and Worcester prehospital services will be leveraged to support the goals ofthe NERCC. Overall, the NERCC Team has the resources, vision, and enthusiasm to develop new translational science and successfully execute the NINDS Stroke Trials Network Phase 1,2 and 3 studies. RELEVANCE (See Instructions): The NERCC will be comprised of Massachusetts General Hospital (MGH), Brigham & Women's Hospital (BWH), Beth Israel Deaconess Medical Center (BIDMC), Boston Medical Center (BMC), Tufts Medical Center (TMC), University of Massachusetts Memorial Medical Center (UMMMC), Spaulding Rehabilitation Hospital Network (SRH) and Boston Children's Hospital (BCH), all organizations with internationally recognized patient care and clinical research programs.

我们建议创建新英格兰地区协调中心(NERCC)，这是一个由 波士顿和马萨诸塞州西部的医院和EMS机构，将作为顶级注册网站和 NINDS中风试验网络充满活力的贡献者。我们的小组包括许多主要的成年人 大波士顿地区的学术中风中心，以及我们30家医院新英格兰TeleStroke转诊 网络将进一步扩大我们的潜在招聘范围。所有核心医院都有经过证明的记录 临床试验的成功管理和执行。特别是，阿里医院已经建立了 研究基础设施，通过强有力的合作在中风神经病学方面执行持续的临床研究 跨学科。首席研究员Lee H.Schwamm医学博士和联合调查员带来了补充 管理成功的转化型临床研究项目的技能，指导方面的成员资格 委员会，以及各自领域的国家领导职位。我们的团队包括经验丰富的临床医生 研究人员：血管神经学、急诊医学、神经血管内科学、神经外科、神经重症 护理、神经成像、中风康复，以及临床前基础和转化性中风调查 成人和儿童。NERCC团队的优势包括1)密切的个人和职业联系 多名调查人员；2)来自大城市地区不同医院的大量患者； 3)具有科学成就、创新和学科记录的现场调查人员组成的人才团队 多中心试验的招募；4)强大的现有NINDS资助的研究和临床试验管理 基础设施；5)现有的临床研究计划，例如.美国国立卫生研究院临床神经学研究所 以及波士顿大学和哈佛大学的翻译科学奖项目； 急性卒中(SPOTRIAS)和神经内科急诊翻译研究专业 治疗试验和NeuroNEXT临床协调中心。此外，与波士顿和 伍斯特医院前服务将被用来支持NERCC的目标。总体而言，NERCC 团队拥有资源、远见和热情来开发新的翻译科学并成功 执行NINDS卒中试验网络阶段1、2和3研究。 相关性(请参阅说明)： NERCC将由马萨诸塞州综合医院(MGH)、Brigham和妇女医院组成 (BWH)、贝丝以色列女执事医疗中心(BIDMC)、波士顿医疗中心(BMC)、塔夫茨医疗 马萨诸塞大学纪念医学中心(TMC)斯波尔丁康复中心(UMMMC) 医院网络(SRH)和波士顿儿童医院(BCH)，所有组织都拥有国际 公认的患者护理和临床研究计划。