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New England Regional Coordinating Center for the NINDS Stroke Trials Network

NINDS 卒中试验网络新英格兰地区协调中心

基本信息

批准号：
9343382
负责人：
Lee H Schwamm
金额：
$ 13.73万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-10-01 至 2017-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9343382
关键词：
Academic Medical Centers Achievement Acute Address Adult Advocacy Agreement Ally American Heart Association Area Award Blood Vessels Boston Caring Child Clinical Clinical Investigator Clinical Research Clinical Sciences Clinical Trials Clinical Trials Network Collaborations Community Hospitals Data Discipline Discipline of Nursing Educational Activities Emergency Medicine Emergency treatment Enrollment Environment Faculty Failure Funding Future General Hospitals Goals Health Hospitals Inpatients Institution Institutional Review Boards Instruction International Investigation Israel Lead Leadership Letters Massachusetts Medical Medical center Mission Modeling Multicenter Trials National Institute of Neurological Disorders and Stroke Neurologist Neurology Neurosciences Research New England Operative Surgical Procedures Patient Care Patient-Focused Outcomes Patients Pediatric Hospitals Performance Phase Phase III Clinical Trials Physicians Population Heterogeneity Populations at Risk Positioning Attribute Pre-hospitalization care Principal Investigator Protocols documentation Public Health Recording of previous events Records Recovery Recurrence Rehabilitation therapy Research Research Activity Research Infrastructure Research Institute Research Personnel Research Training Resources Risk Role Rural Hospitals Science Seasons Services Site Stroke Stroke prevention Therapeutic Training Training and Infrastructure Translating Translational Research United States National Institutes of Health Universities University Hospitals Vision Woman acute stroke base experience improved improved outcome innovation member metropolitan multidisciplinary network models neuroimaging neurosurgery next generation novel novel therapeutics operation patient population pre-clinical programs research study skills stroke intervention stroke rehabilitation success treatment trial

项目摘要

We propose to create the New England Regional Coordinating Center (NERCC), an integrated team of hospitals and EMS agencies in Boston and Western Massachusetts that will serve as a top-enrolling site and vibrant contributor to the NINDS Stroke Trials Network. Our group includes many ofthe major adult academic stroke centers in the Greater Boston area, and our 30 hospital New England TeleStroke referral network will extend our potential recruitment even further. Ail core hospitals have a proven track record of successful management and performance ofclinical trials. In particular, ali hospitals have an established research infrastructure that performs ongoing clinical research in stroke neurology with strong collaborations across disciplines. Principal investigator Lee H. Schwamm, MD, and Co-Investigators bring a complementary set of skills in managing successful translational clinical research programs, membership on Steering Committees, and positions of national leadership in their fields. Our team includes seasoned clinical investigators in vascular neurology, emergency medicine, neuroendovascular, neurosurgery, neurointensive care, neuroimaging, stroke rehabilitation, and preclinical basic and translational stroke investigation in both adults and children. Strengths ofthe NERCC team include 1) close personal and professional ties between multiple investigators; 2) large patient population from diverse hospital settings in a major metropolitan area; 3) talented teams of site investigators with track records of scientific achievement, innovation, and subject recruitment in multicenter trials; 4) robust existing NINDS-funded research and clinical trial management infrastructure; 5) existing clinical research programs, e.g.. Neurology Clinical Research Institute, NIH Clinical and Translational Science Award programs at Boston University and across Harvard; Sites in the Specialized Programs of Translational Research in Acute Stroke (SPOTRIAS) and Neurology Emergency Treatment Trials and NeuroNEXT Clinical Coordinating Center. In addition, integration with Boston and Worcester prehospital services will be leveraged to support the goals ofthe NERCC. Overall, the NERCC Team has the resources, vision, and enthusiasm to develop new translational science and successfully execute the NINDS Stroke Trials Network Phase 1,2 and 3 studies. RELEVANCE (See Instructions): The NERCC will be comprised of Massachusetts General Hospital (MGH), Brigham & Women's Hospital (BWH), Beth Israel Deaconess Medical Center (BIDMC), Boston Medical Center (BMC), Tufts Medical Center (TMC), University of Massachusetts Memorial Medical Center (UMMMC), Spaulding Rehabilitation Hospital Network (SRH) and Boston Children's Hospital (BCH), all organizations with internationally recognized patient care and clinical research programs.

我们建议建立新英格兰区域协调中心，这是一个综合小组，波士顿和马萨诸塞州西部的医院和EMS机构将作为最佳招募地点， NINDS中风试验网络的活跃贡献者。我们的团队包括许多成年人大波士顿地区的学术中风中心，以及我们新英格兰的30家医院的远程中风转诊网络将进一步扩大我们的潜在招聘。所有核心医院都有良好的记录，临床试验的成功管理和绩效。特别是阿里医院，研究基础设施，通过强有力的合作，在卒中神经病学方面进行持续的临床研究跨学科。首席研究员Lee H. Schwamm，MD和合作研究者带来了一个互补的一套管理成功的转化临床研究项目的技能，指导成员委员会，并在其领域的国家领导职位。我们的团队包括经验丰富的临床血管神经病学、急诊医学、神经血管内、神经外科、神经强化护理、神经影像学、卒中康复以及临床前基础和转化卒中研究，成人和儿童。NERCC团队的优势包括：1）密切的个人和专业联系，多名研究者; 2）来自大都市地区不同医院环境的大量患者人群; 3)有才华的现场调查员团队，具有科学成就，创新和主题的跟踪记录多中心试验招募; 4）强大的现有NINDS资助的研究和临床试验管理基础设施; 5）现有的临床研究计划，例如。美国国立卫生研究院神经病学临床研究所以及波士顿大学和哈佛的转化科学奖项目; 转化研究在急性中风（SPOTRIAS）和神经病学急诊专业计划治疗试验和NeuroNEXT临床协调中心。此外，与波士顿和伍斯特院前服务将被用来支持NERCC的目标。总的来说，NERCC 团队有资源、远见和热情来开发新的转化科学，并成功地执行NINDS卒中试验网络1、2和3期研究。相关性（见说明）： NERCC将由马萨诸塞州总医院（MGH）、布里格姆妇女医院（Brigham & Women's Hospital） (BWH)，贝斯以色列女执事医疗中心（BIDMC），波士顿医疗中心（BMC），塔夫茨医疗中心（TMC），马萨诸塞州纪念医学中心（UMMMC），斯波尔丁康复医院网络（SRH）和波士顿儿童医院（BCH），所有国际组织公认的病人护理和临床研究计划。