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New England Regional Coordinating Center for the NINDS Stroke Trials Network

NINDS 卒中试验网络新英格兰地区协调中心

基本信息

批准号：
9343382
负责人：
Lee H Schwamm
金额：
$ 13.73万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-10-01 至 2017-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9343382
关键词：
Academic Medical Centers Achievement Acute Address Adult Advocacy Agreement Ally American Heart Association Area Award Blood Vessels Boston Caring Child Clinical Clinical Investigator Clinical Research Clinical Sciences Clinical Trials Clinical Trials Network Collaborations Community Hospitals Data Discipline Discipline of Nursing Educational Activities Emergency Medicine Emergency treatment Enrollment Environment Faculty Failure Funding Future General Hospitals Goals Health Hospitals Inpatients Institution Institutional Review Boards Instruction International Investigation Israel Lead Leadership Letters Massachusetts Medical Medical center Mission Modeling Multicenter Trials National Institute of Neurological Disorders and Stroke Neurologist Neurology Neurosciences Research New England Operative Surgical Procedures Patient Care Patient-Focused Outcomes Patients Pediatric Hospitals Performance Phase Phase III Clinical Trials Physicians Population Heterogeneity Populations at Risk Positioning Attribute Pre-hospitalization care Principal Investigator Protocols documentation Public Health Recording of previous events Records Recovery Recurrence Rehabilitation therapy Research Research Activity Research Infrastructure Research Institute Research Personnel Research Training Resources Risk Role Rural Hospitals Science Seasons Services Site Stroke Stroke prevention Therapeutic Training Training and Infrastructure Translating Translational Research United States National Institutes of Health Universities University Hospitals Vision Woman acute stroke base experience improved improved outcome innovation member metropolitan multidisciplinary network models neuroimaging neurosurgery next generation novel novel therapeutics operation patient population pre-clinical programs research study skills stroke intervention stroke rehabilitation success treatment trial

项目摘要

We propose to create the New England Regional Coordinating Center (NERCC), an integrated team of hospitals and EMS agencies in Boston and Western Massachusetts that will serve as a top-enrolling site and vibrant contributor to the NINDS Stroke Trials Network. Our group includes many ofthe major adult academic stroke centers in the Greater Boston area, and our 30 hospital New England TeleStroke referral network will extend our potential recruitment even further. Ail core hospitals have a proven track record of successful management and performance ofclinical trials. In particular, ali hospitals have an established research infrastructure that performs ongoing clinical research in stroke neurology with strong collaborations across disciplines. Principal investigator Lee H. Schwamm, MD, and Co-Investigators bring a complementary set of skills in managing successful translational clinical research programs, membership on Steering Committees, and positions of national leadership in their fields. Our team includes seasoned clinical investigators in vascular neurology, emergency medicine, neuroendovascular, neurosurgery, neurointensive care, neuroimaging, stroke rehabilitation, and preclinical basic and translational stroke investigation in both adults and children. Strengths ofthe NERCC team include 1) close personal and professional ties between multiple investigators; 2) large patient population from diverse hospital settings in a major metropolitan area; 3) talented teams of site investigators with track records of scientific achievement, innovation, and subject recruitment in multicenter trials; 4) robust existing NINDS-funded research and clinical trial management infrastructure; 5) existing clinical research programs, e.g.. Neurology Clinical Research Institute, NIH Clinical and Translational Science Award programs at Boston University and across Harvard; Sites in the Specialized Programs of Translational Research in Acute Stroke (SPOTRIAS) and Neurology Emergency Treatment Trials and NeuroNEXT Clinical Coordinating Center. In addition, integration with Boston and Worcester prehospital services will be leveraged to support the goals ofthe NERCC. Overall, the NERCC Team has the resources, vision, and enthusiasm to develop new translational science and successfully execute the NINDS Stroke Trials Network Phase 1,2 and 3 studies. RELEVANCE (See Instructions): The NERCC will be comprised of Massachusetts General Hospital (MGH), Brigham & Women's Hospital (BWH), Beth Israel Deaconess Medical Center (BIDMC), Boston Medical Center (BMC), Tufts Medical Center (TMC), University of Massachusetts Memorial Medical Center (UMMMC), Spaulding Rehabilitation Hospital Network (SRH) and Boston Children's Hospital (BCH), all organizations with internationally recognized patient care and clinical research programs.

我们建议成立新英格兰地区协调中心（NERCC），一个由