Bright Particle

亮粒子

• 批准号: 10046496
• 金额: $ 6.37万
• 依托单位: SFEROLA LTD
• 依托单位国家: 英国
• 项目类别: Grant for R&D
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=10046496
• 关键词: Bright; Particle

This project is a proof-of-concept project to demonstrate the feasibility of a novel crystallisation method to control particle size and properties to enable fast development of new drug substances into effective drug products. We will use the funds to build a proof-of-concept test rig then and conduct experiments to generate engineered particles of desired properties. Finally, we will test the physico-chemical properties of our engineered powder and its aerodynamic performance.Our mission is to unlock the potential of unused or under-utilised drugs because of poor aqueous solubility by developing and applying particle engineering technology that can address the most difficult challenges in drug formulations. We aim to collaborate with universities and pharmaceutical companies to turn new and complex drugs into usable products that can benefit the patients in need. This project will enable us to develop the basic capabilities to take on this challenge.Our technology will focus on optimising drug formulations for inhalation route. It is well known that inhalation route is ideal for delivery of drugs targeting diseases affecting the lung such as asthma, COPD, cystic fibrosis as well as lung cancer. Additionally, the pulmonary system can also be used to deliver drugs for other conditions due to its many benefits including large surface area, less metabolism, high blood flow, highly absorptive membrane, and less dose required leading to significant reduction in chronic side effects. However, this route comes with significant challenges that are difficult to overcome such as device design and formulation development. These problems can be overcome with an appropriate particle engineering technology approach, minimising the development requirements from the formulation and device perspectives.

这个项目是一个概念验证项目，旨在展示一种新的结晶方法的可行性，以控制颗粒大小和性质，使新的药物物质能够快速开发成有效的药物产品。然后，我们将用这笔资金建造一个概念验证试验台，并进行实验，以产生所需特性的工程粒子。最后，我们将测试我们的工程粉末的物理化学性质及其空气动力学性能。我们的任务是通过开发和应用粒子工程技术来解决药物配方中最困难的挑战，从而释放未使用或未充分利用的药物的潜力，因为这些药物的水溶解性较差。我们的目标是与大学和制药公司合作，将新的复杂药物转化为可用产品，使有需要的患者受益。该项目将使我们能够发展应对这一挑战的基本能力。我们的技术将专注于优化吸入途径的药物配方。众所周知，吸入途径是针对哮喘、COPD、囊性纤维化和肺癌等影响肺部疾病的药物输送的理想途径。此外，肺系统还可以用于治疗其他疾病的药物，因为它有许多优点，包括大表面积、较少的新陈代谢、高血流、高吸收膜和较少的所需剂量，从而显著减少慢性副作用。然而，这条路线伴随着难以克服的重大挑战，如设备设计和配方开发。这些问题可以通过适当的粒子工程技术方法来克服，从配方和设备的角度将开发要求降至最低。