Development of a Quantitative Iron Characterization System for Alzheimer's Disease Using Computed Laminography X-ray Fluorescence Imaging (CL-XRFI)
使用计算机断层扫描 X 射线荧光成像 (CL-XRFI) 开发阿尔茨海默氏病的定量铁表征系统
基本信息
- 批准号:10306411
- 负责人:
- 金额:$ 79.52万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-12-01 至 2022-11-30
- 项目状态:已结题
- 来源:
- 关键词:AblationAlzheimer&aposs DiseaseAmyloid beta-ProteinAnodesBiologicalBrainBrain regionCellular StructuresCessation of lifeData CollectionDetectionDevelopmentDrug DesignDrug TargetingEffectivenessElementsEnsureEventExcisionFeedbackFluorescenceGoalsHourImageIncidenceInductively Coupled Plasma Mass SpectrometryInformation DistributionIronIron Chelating AgentsLaboratoriesLasersLegal patentLettersLinkMeasuresMetalsMethodsMicroscopyMicrotomyNerve DegenerationNeurodegenerative DisordersOpticsParkinson DiseasePathologicPathway interactionsPerformancePharmaceutical PreparationsPhasePreparationPropertyResearchResolutionRoentgen RaysRotationSamplingScanningSchemeSignal TransductionSliceSolidSourceSpecimenSpeedSurfaceSynchrotronsSystemTechniquesTechnologyTimeTrace ElementsWorkabsorptionbasebrain tissuecommercializationdesigndetection sensitivitydetectorfluorescence imagingimaging systemimprovedinnovationnovelnovel therapeuticsphantom modelpreventprototypereconstructionsuccesstargeted treatmenttheoriestherapeutic developmenttherapeutic target
项目摘要
The discovery of ferroptosis has invigorated new therapeutics to prevent and/or alter
pathological iron distribution in the brain correlated with Alzheimer’s disease (AD) and other
neurodegenerative diseases. To efficiently evaluate new drug designs, techniques capable of
directly imaging and quantifying the trace levels of iron in brain samples are required. Current
approaches include LA-ICPMS and synchrotron microXRF, which each have their own
drawbacks in terms of speed, quantification reliability, and accessibility.
We propose to develop a scheme called computed laminography x-ray fluorescence imaging
(CL-XRFI). In this novel system design, an x-ray beam is focused into a pencil-like beam
incident upon a sample at a very low angle (3 degrees). A detector is placed parallel to the
sample surface to maximize solid angle. Acquisition is similar in concept to absorption-based
laminography, in which acquisition at multiple angles are taken for reconstruction of the signal
origin. The system design is uniquely enabled by the company’s patented high brightness x-ray
source and its proprietary x-ray optic technology that provides the large working distances
necessary for the technique to work.
The proposed Phase I 6-month project is a proof-of-principle demonstration of the sensitivity
and throughput of a breadboard low angle incidence fluorescence system. The proposed Phase II
24-month project is to develop a complete prototype of the CL-XRFI.
铁性下垂的发现激发了预防和/或改变的新疗法
脑内病理性铁的分布与阿尔茨海默病(AD)和其他
神经退行性疾病。为了有效地评估新药设计,能够
直接成像和量化大脑样本中的微量铁水平是必要的。当前
方法包括LA-ICPMS和同步加速器MicroXRF,它们都有自己的方法
在速度、量化可靠性和可访问性方面存在缺陷。
我们建议开发一种称为计算机层析x射线荧光成像的方案。
(CL-XRFI)。在这种新颖的系统设计中,x射线束被聚焦成铅笔状的光束。
以非常小的角度(3度)入射到样品上。探测器被放置在与
样本表面,以最大限度地提高立体角度。收购在概念上类似于基于吸收的收购
层析成像技术,采用多角度采集以重建信号
起源。该系统的设计是由该公司专利的高亮度X射线独一无二的
光源及其专有的X射线光学技术提供了大的工作距离
是这项技术发挥作用所必需的。
拟议的为期6个月的第一阶段项目是对敏感性的原则证明
和面包板小角度入射荧光系统的吞吐量。建议的第二期工程
为期24个月的项目是开发CL-XRFI的完整原型。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Wenbing Yun其他文献
Wenbing Yun的其他文献
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{{ truncateString('Wenbing Yun', 18)}}的其他基金
Cryogenic High-throughput Cellular Imaging System
低温高通量细胞成像系统
- 批准号:
10545696 - 财政年份:2022
- 资助金额:
$ 79.52万 - 项目类别:
Cryogenic High-throughput Cellular Imaging System
低温高通量细胞成像系统
- 批准号:
10701888 - 财政年份:2022
- 资助金额:
$ 79.52万 - 项目类别:
Development of a Bio-tissue Oxygenation Nanophosphor Enabled Sensing (BONES) system for Quantifying Hypoxia in Bone Marrow
开发用于量化骨髓缺氧的生物组织氧化纳米磷传感 (BONES) 系统
- 批准号:
10255544 - 财政年份:2021
- 资助金额:
$ 79.52万 - 项目类别:
Development of a Bio-tissue Oxygenation Nanophosphor Enabled Sensing (BONES) system for Quantifying Hypoxia in Bone Marrow
开发用于量化骨髓缺氧的生物组织氧化纳米磷传感 (BONES) 系统
- 批准号:
10573284 - 财政年份:2021
- 资助金额:
$ 79.52万 - 项目类别:
Development of a Bio-tissue Oxygenation Nanophosphor Enabled Sensing (BONES) system for Quantifying Hypoxia in Bone Marrow
开发用于量化骨髓缺氧的生物组织氧化纳米磷传感 (BONES) 系统
- 批准号:
10408542 - 财政年份:2021
- 资助金额:
$ 79.52万 - 项目类别:
Development of a Quantitative Iron Characterization System for Alzheimer's Disease Using Computed Laminography X-ray Fluorescence Imaging (CL-XRFI)
使用计算机断层扫描 X 射线荧光成像 (CL-XRFI) 开发阿尔茨海默氏病的定量铁表征系统
- 批准号:
10011049 - 财政年份:2020
- 资助金额:
$ 79.52万 - 项目类别:
Development of a low dose clinical lung screening prototype for early detection of COPD and lung cancer using a novel x-ray source to enable Talbot-Lau interferometry
使用新型 X 射线源开发低剂量临床肺部筛查原型,以实现 COPD 和肺癌的早期检测,以实现 Talbot-Lau 干涉测量
- 批准号:
10082257 - 财政年份:2020
- 资助金额:
$ 79.52万 - 项目类别:
A sub-cellular micro x-ray fluorescence system for elemental imaging at fast acquisition times in biological tissue
一种亚细胞微 X 射线荧光系统,用于在生物组织中快速采集元素成像
- 批准号:
10019577 - 财政年份:2019
- 资助金额:
$ 79.52万 - 项目类别:
Development of a laboratory XANES system for the analysis of metals in tissue for cancer research and chemotherapy drug development
开发实验室 XANES 系统,用于分析组织中的金属,用于癌症研究和化疗药物开发
- 批准号:
9559611 - 财政年份:2018
- 资助金额:
$ 79.52万 - 项目类别:
A high resolution and high DQE detector optimized for mammography using single-shot bi-directional tri-contrast imaging
使用单次双向三对比成像针对乳腺 X 线摄影进行优化的高分辨率和高 DQE 探测器
- 批准号:
9346063 - 财政年份:2016
- 资助金额:
$ 79.52万 - 项目类别:














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