Development of a Quantitative Iron Characterization System for Alzheimer's Disease Using Computed Laminography X-ray Fluorescence Imaging (CL-XRFI)

使用计算机断层扫描 X 射线荧光成像 (CL-XRFI) 开发阿尔茨海默氏病的定量铁表征系统

基本信息

  • 批准号:
    10306411
  • 负责人:
  • 金额:
    $ 79.52万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-12-01 至 2022-11-30
  • 项目状态:
    已结题

项目摘要

The discovery of ferroptosis has invigorated new therapeutics to prevent and/or alter pathological iron distribution in the brain correlated with Alzheimer’s disease (AD) and other neurodegenerative diseases. To efficiently evaluate new drug designs, techniques capable of directly imaging and quantifying the trace levels of iron in brain samples are required. Current approaches include LA-ICPMS and synchrotron microXRF, which each have their own drawbacks in terms of speed, quantification reliability, and accessibility. We propose to develop a scheme called computed laminography x-ray fluorescence imaging (CL-XRFI). In this novel system design, an x-ray beam is focused into a pencil-like beam incident upon a sample at a very low angle (3 degrees). A detector is placed parallel to the sample surface to maximize solid angle. Acquisition is similar in concept to absorption-based laminography, in which acquisition at multiple angles are taken for reconstruction of the signal origin. The system design is uniquely enabled by the company’s patented high brightness x-ray source and its proprietary x-ray optic technology that provides the large working distances necessary for the technique to work. The proposed Phase I 6-month project is a proof-of-principle demonstration of the sensitivity and throughput of a breadboard low angle incidence fluorescence system. The proposed Phase II 24-month project is to develop a complete prototype of the CL-XRFI.
铁下垂的发现激发了新的治疗方法来预防和/或改变

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Wenbing Yun其他文献

Wenbing Yun的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Wenbing Yun', 18)}}的其他基金

Cryogenic High-throughput Cellular Imaging System
低温高通量细胞成像系统
  • 批准号:
    10545696
  • 财政年份:
    2022
  • 资助金额:
    $ 79.52万
  • 项目类别:
Cryogenic High-throughput Cellular Imaging System
低温高通量细胞成像系统
  • 批准号:
    10701888
  • 财政年份:
    2022
  • 资助金额:
    $ 79.52万
  • 项目类别:
Development of a Bio-tissue Oxygenation Nanophosphor Enabled Sensing (BONES) system for Quantifying Hypoxia in Bone Marrow
开发用于量化骨髓缺氧的生物组织氧化纳米磷传感 (BONES) 系统
  • 批准号:
    10255544
  • 财政年份:
    2021
  • 资助金额:
    $ 79.52万
  • 项目类别:
Development of a Bio-tissue Oxygenation Nanophosphor Enabled Sensing (BONES) system for Quantifying Hypoxia in Bone Marrow
开发用于量化骨髓缺氧的生物组织氧化纳米磷传感 (BONES) 系统
  • 批准号:
    10573284
  • 财政年份:
    2021
  • 资助金额:
    $ 79.52万
  • 项目类别:
Development of a Bio-tissue Oxygenation Nanophosphor Enabled Sensing (BONES) system for Quantifying Hypoxia in Bone Marrow
开发用于量化骨髓缺氧的生物组织氧化纳米磷传感 (BONES) 系统
  • 批准号:
    10408542
  • 财政年份:
    2021
  • 资助金额:
    $ 79.52万
  • 项目类别:
Development of a Quantitative Iron Characterization System for Alzheimer's Disease Using Computed Laminography X-ray Fluorescence Imaging (CL-XRFI)
使用计算机断层扫描 X 射线荧光成像 (CL-XRFI) 开发阿尔茨海默氏病的定量铁表征系统
  • 批准号:
    10011049
  • 财政年份:
    2020
  • 资助金额:
    $ 79.52万
  • 项目类别:
Development of a low dose clinical lung screening prototype for early detection of COPD and lung cancer using a novel x-ray source to enable Talbot-Lau interferometry
使用新型 X 射线源开发低剂量临床肺部筛查原型,以实现 COPD 和肺癌的早期检测,以实现 Talbot-Lau 干涉测量
  • 批准号:
    10082257
  • 财政年份:
    2020
  • 资助金额:
    $ 79.52万
  • 项目类别:
A sub-cellular micro x-ray fluorescence system for elemental imaging at fast acquisition times in biological tissue
一种亚细胞微 X 射线荧光系统,用于在生物组织中快速采集元素成像
  • 批准号:
    10019577
  • 财政年份:
    2019
  • 资助金额:
    $ 79.52万
  • 项目类别:
Development of a laboratory XANES system for the analysis of metals in tissue for cancer research and chemotherapy drug development
开发实验室 XANES 系统,用于分析组织中的金属,用于癌症研究和化疗药物开发
  • 批准号:
    9559611
  • 财政年份:
    2018
  • 资助金额:
    $ 79.52万
  • 项目类别:
A high resolution and high DQE detector optimized for mammography using single-shot bi-directional tri-contrast imaging
使用单次双向三对比成像针对乳腺 X 线摄影进行优化的高分辨率和高 DQE 探测器
  • 批准号:
    9346063
  • 财政年份:
    2016
  • 资助金额:
    $ 79.52万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了