A high resolution and high DQE detector optimized for mammography using single-shot bi-directional tri-contrast imaging

使用单次双向三对比成像针对乳腺 X 线摄影进行优化的高分辨率和高 DQE 探测器

• 批准号: 9346063
• 负责人: Wenbing Yun
• 金额: $ 71.96万
• 依托单位: SIGRAY, INC.
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-05 至 2019-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9346063
• 关键词: American; Area; Benign; Biological; Breast Cancer Treatment; Breast Microcalcification; Cancerous; Classification; Clinical; Clinics and Hospitals; Darkness; Degenerative polyarthritis; Development; Diagnosis; Diagnostic radiologic examination; Dimensions; Discrimination; Disease Progression; Dose; Engineering; Ensure; Equipment; Excision; Face; Funding; Goals; Image; Imaging Techniques; Interferometry; Joints; Laboratories; Limb structure; Malignant - descriptor; Mammary Gland Parenchyma; Mammography; Modernization; Monitor; Morphology; Operating System; Patients; Pattern; Performance; Phase; Physics; Premalignant; Principal Investigator; Radiation; Refractive Indices; Resolution; Roentgen Rays; Screening for cancer; Side; Small Business Innovation Research Grant; Soft Tissue Disorder; Solid; Source; System; Techniques; Technology; Thick; Time; Tissues; United States National Institutes of Health; Variant; Woman; Work; absorption; base; bioimaging; clinical imaging; commercialization; contrast imaging; cost; design; detector; imaging capabilities; imaging system; innovation; malignant breast neoplasm; meetings; novel; optical imaging; pre-clinical; programs; prototype; public health relevance; quantum; screening; soft tissue; stem; success

 DESCRIPTION (provided by applicant): X-ray tricontrast imaging provides three different modes of contrast: absorption contrast (the mechanism behind how conventional medical X-ray imaging equipment images), phase contrast (which provides up to 1000X more contrast than absorption-based contrast for soft tissue), and scatter contrast (which provides information of features at dimensions smaller than the resolution of absorption and phase contrast). Access to all three contrast modes is widely considered one of the most exciting developments in modern X-ray physics, and has significant potential to change the face of biomedical imaging for early detection of cancer, osteoarthritis, and other soft tissue diseases. The recent development of Talbot-Lau interferometry, a grating- based technique that uses three gratings to achieve tricontrast imaging, has high potential to achieve tricontrast imaging in clinical use. However, there are several major limitations stemming from the use of two out of the three gratings. These two gratings are not entirely necessary and the removal of the gratings would still allow the technique to work, as long as substantial innovation is made to the source and to the detector. We propose to develop a high detective quantum efficiency (DQE) microstructured detector with good resolution to enable clinical Talbot interferometers without need of one of the two problematic gratings. The other grating may be removed by innovation on the source, for which we have also devised a proposal that has previously been submitted to the NIH and is awaiting a final funding decision (it received an outstanding impact score of 20). The proposed Phase I 6-month project is a proof-of-principle demonstration that the microstructured detector can be manufactured and would provide high detective quantum efficiency, and the proposed Phase II 24-month project would produce working prototypes of the detector.

 DESCRIPTION (provided by applicable): X-ray tricontrast imaging provides three different modes of contrast: abstraction contrast (the mechanism behind how conventional medical X-ray imaging equipment images), phase contrast (which provides up to 1000X more contrast than abstraction-based contrast for soft tissue), and scatter contrast (which provides information of features at dimensions smaller than the resolution of abstraction and phase contrast).访问所有三种对比模式被广泛认为是现代X射线物理学中最令人兴奋的发展之一，并且具有改变生物医学成像的巨大潜力，以早日检测到癌症，骨关节炎和其他软组织疾病。 Talbot-Lau干扰的最新发展是一种基于光栅的技术，它使用三个光栅来实现TriconTrast成像，具有在临床使用中实现三膜成像的很高潜力。但是，在三个光栅中的两个使用中，有几个主要局限性。这两个光栅不是完全必要的，只要对源和检测器进行实质性创新，拆除光栅仍然可以使技术工作。我们建议以良好的分辨率开发高侦探量子效率（DQE）微结构检测器，以实现临床talbot干涉仪，而无需两个有问题的光栅之一。另一个光栅可以通过对来源的创新来删除，我们还为此提出了一项以前已提交给NIH的提案，并正在等待最终的资金决定（它获得了20个出色的影响得分20）。拟议的I期6个月项目是原则证明，可以制造微结构检测器并提供高侦探量子效率，而拟议的II期24个月项目将产生检测器的工作原型。