Predicting Sleep, Smoking and Lung Health Disparities in at-risk Black African American Adults

预测高危黑人非裔美国成年人的睡眠、吸烟和肺部健康差异

• 批准号: 10307075
• 负责人: Freda Patterson
• 金额: $ 61.27万
• 依托单位: TEMPLE UNIV OF THE COMMONWEALTH
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-04-01 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10307075
• 关键词: Acculturation; Address; Adult; African American; African American population; Age; Alcohols; Anxiety; Attitude; Belief; Black Populations; Black race; Body mass index; Chronic Obstructive Pulmonary Disease; Cigarette; Classification; Crowding; Data; Diagnosis; Diet; Disease Progression; Enrollment; Environmental Risk Factor; Epidemiology; Equation; Esthetics; Etiology; Future; Goals; Growth; Habits; Health; Heterogeneity; Hour; Household; IL8 gene; Impairment; Incidence; Individual; Inflammation; Interleukin-1; Interleukin-6; Intervention; Knowledge; Lead; Lighting; Measures; Mental Depression; Minority Health Research; Mission; Modeling; National Institute on Minority Health and Health Disparities; Nicotine Dependence; Not Hispanic or Latino; Observational Study; Onset of illness; Outcome; Phenotype; Predictive Factor; Primary Prevention; Pulmonary Function Test/Forced Expiratory Volume 1; Quality of life; Race; Reporting; Research Support; Risk; Risk Factors; Sampling; Secondary Prevention; Sleep; Sleep Deprivation; Smoker; Smoking; Smoking Behavior; Smoking and Health Research; Social support; Subgroup; Symptoms; TNF gene; Testing; Time; Tobacco use; Work; aged; base; cigarette smoking; classification trees; contextual factors; demographics; density; design; disparity reduction; experience; health care availability; health care quality; health disparity; health disparity populations; high risk; high risk population; inflammatory marker; lung health; middle age; minority health disparity; modifiable risk; mortality; multidisciplinary; neighborhood safety; perceived discrimination; poor sleep; prospective; pulmonary function; racial disparity; regression trees; sedentary; sleep health; sleep quality; social; social cohesion; social factors; systemic inflammatory response

Project Abstract Black/African American's (BAAs) are more likely to report insufficient sleep duration (<7 hours) and other sleep deficiencies (e.g., poor sleep quality), and to have advanced Chronic Obstructive Pulmonary Disease (COPD), than Non-Hispanic Whites (NHW) with similar smoking behaviors. Insufficient sleep has been related to: (1) continued cigarette smoking, and (2) impaired lung function in healthy adults. Thus, sleep deficiencies could be an “upstream” primary and/or secondary prevention target to address racial disparities in tobacco use and COPD onset and progression. Not known are the multi-level (i.e., individual, social and environmental) factors that predict insufficient sleep duration and other sleep deficiencies in BAA's across time, and the extent to which sleep deficiencies predict poorer health outcomes such as continued tobacco use and worsening lung function in BAA smokers. To address these knowledge gaps, we will conduct a multi-disciplinary 5-year prospective observational study that will enroll and follow a representative sample of 480 BAAs who are current smokers, are aged >39 years, and who have prodromal (GOLD stage 0) or early stage COPD (GOLD stage 1-2). We will prospectively examine key individual, social, and environmental variables in concert with objectively measured sleep metrics, tobacco use, inflammatory markers, and lung function in this health disparate sample. Longitudinal mixed, classification and regression, and structural equation modeling will define key predictors (and future intervention targets) of sleep deficiencies in BAA's as well as delineate the extent to which insufficient sleep (and other sleep deficiencies) interact with tobacco use and inflammation markers to predict worsening lung function. The expected outcome from this work is to define multi-level phenotypes of risk for sleep deficiencies, continued tobacco use, and worsening lung function in this health disparate population of mid-life BAA smokers. This work directly aligns with, and advances the NIMHD mission to conduct and support research in minority health and health disparities.

项目摘要 黑人/非洲裔美国人（BAA）更有可能报告睡眠时间不足（<7小时） 以及其他睡眠不足（例如，睡眠质量差），并有慢性 阻塞性肺疾病（COPD），比非西班牙裔白人（NHW）吸烟相似 行为。睡眠不足与以下因素有关：（1）持续吸烟;（2） 健康成人的肺功能受损。因此，睡眠不足可能是一个“上游”， 一级和/或二级预防目标，以解决烟草使用方面的种族差异， COPD发作和进展。不知道的是多级（即，个人、社会和 环境）因素预测睡眠时间不足和其他睡眠不足， BAA的跨时间，以及睡眠不足的程度预测较差的健康结果 例如BAA吸烟者持续吸烟和肺功能恶化。解决这些 知识差距，我们将进行一项多学科的5年前瞻性观察研究， 将招募并随访480名BAA的代表性样本，这些BAA目前吸烟，年龄 >39岁，并且患有前驱期（GOLD阶段0）或早期COPD（GOLD阶段1-2）。 我们将前瞻性地研究关键的个人，社会和环境变量， 客观测量的睡眠指标，烟草使用，炎症标志物和肺功能， 健康状况不同的样本。纵向混合型、分类回归型和结构型 方程模型将定义睡眠的关键预测因素（和未来的干预目标） BAA的缺乏以及描绘睡眠不足（和其他睡眠）的程度 缺乏）与烟草使用和炎症标志物相互作用，以预测肺部恶化 功能这项工作的预期结果是确定多层次的风险表型， 睡眠不足，持续吸烟，肺功能恶化，在这个健康的不同 中年BAA吸烟者。这项工作直接与NIMHD保持一致，并推动了NIMHD的发展。 使命是开展和支持对少数民族健康和健康差距的研究。

项目成果

HIV status and sleep disturbance in college students and relationship with smoking.

大学生的艾滋病毒状况和睡眠障碍及其与吸烟的关系。

• DOI: 10.1016/j.sleh.2019.05.002
• 发表时间: 2019
• 期刊: Sleep health
• 影响因子: 4.1
• 作者: Patterson,Freda;Connick,Elizabeth;Brewer,Benjamin;Grandner,MichaelA
• 通讯作者: Grandner,MichaelA

Cigarettes at ¢35 a pack, in 2019….

2019 年，香烟价格为每包 35 欧元……。

• DOI: 10.1136/jech-2019-212333
• 发表时间: 2019
• 期刊: Journal of epidemiology and community health
• 影响因子: 6.3
• 作者: Patterson,Freda;Farquhar,WilliamB
• 通讯作者: Farquhar,WilliamB

Does meeting physical activity recommendations ameliorate association between television viewing with cardiovascular disease risk? A cross-sectional, population-based analysis.

满足身体活动建议是否会改善看电视与心血管疾病风险之间的关联？

• DOI: 10.1136/bmjopen-2019-036507
• 发表时间: 2020
• 期刊: BMJ open
• 影响因子: 2.9
• 作者: Patterson,Freda;Mitchell,JonathanA;Dominick,Gregory;Lozano,AliciaJ;Huang,Liming;Hanlon,AlexandraL
• 通讯作者: Hanlon,AlexandraL