Effects of Sleep Modification on Smoking Cessations and Cardiovascular Health

睡眠改变对戒烟和心血管健康的影响

• 批准号: 9432534
• 负责人: Freda Patterson
• 金额: $ 30.06万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-03-01 至 2021-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9432534
• 关键词: Adult; Aerobic; Aerobic Exercise; Age; American; Blinded; Blood Pressure; Cardiac rehabilitation; Cardiovascular Diseases; Cardiovascular system; Centers of Research Excellence; Chronic; Communities; Comorbidity; Data; Experimental Designs; Goals; Health; Independent Living; Individual; Interval training; Intervention; Intervention Studies; Link; Measures; Mediating; Modification; Outcome; Oxygen Consumption; Persons; Physical activity; Population; Program Reviews; Protocols documentation; Quality of life; Randomized; Recommendation; Research; Rest; Safety; Sleep; Stimulus; Stroke; Testing; Time; Training; Training Programs; Walking; acute stroke; aging population; arm; brachial artery; cardiovascular fitness; cardiovascular health; chronic stroke; comparative efficacy; cost; disability; exercise intensity; exercise training; high risk; improved; intervention effect; novel; post stroke; primary outcome; programs; secondary outcome; sedentary; smoking cessation; stroke incidence; stroke survivor; success; therapy design; treadmill training; walking speed

PROJECT SUMMARY/ABSTRACT The overarching goal of this research is to develop interventions that improve the overall health and quality of life of individuals post-stroke. It is estimated that 75% of all stroke survivors have comorbid cardiovascular conditions and significantly limited cardiovascular capacity. Many studies have shown that cardiovascular fitness after stroke is not commensurate with independent function and is a major contributor to post-stroke disability. The onset of disability makes it difficult for stroke survivors to engage in physical activity, causing them to remain sedentary and extremely inactive and thus a vicious cycle of disability�inactivity�poor cardiovascular fitness ensues. Even after intervention, most stroke survivors VO2peak levels remain below the suggested minimum required for independent living. It is therefore necessary to test new interventions that result in greater improvements in cardiovascular fitness and health and walking function after stroke. Among individuals with cardiovascular disease, recent studies have found a high intensity interval training program (HIIT) to be as safe and a more effective stimulus for improving cardiovascular fitness and health compared to traditional aerobic training programs. The efficacy of a HIIT program has not been tested in persons with chronic stroke, but given the success in other populations, it is a promising intervention to investigate in this group. Therefore, the primary aim of this proposal is to test whether a HIIT program results in greater improvements in cardiovascular health and fitness compared to a standard aerobic training program in those with chronic stroke. The secondary aims are to: a) test whether a HIIT program can result in greater improvements in walking function and activity than a standard aerobic training program and b) test whether improvements in cardiovascular fitness and real-world physical activity are linked. Using a randomized controlled experimental design, 53 chronic (> 6 months) stroke survivors, will receive either 12 weeks of a HIIT program or 12 weeks of a standard aerobic treadmill training program. The primary and secondary outcomes of cardiovascular health and fitness and walking activity will be assessed by blinded evaluators prior to initiating treatment (baseline) and immediately after the last treatment (12 weeks post baseline). The expected positive effects of this novel intervention will provide rationale for recommendations for exercise training in chronic stroke and data for larger studies combining aerobic training with interventions designed to improve real-world daily physical activity after stroke.

项目总结/摘要 这项研究的总体目标是制定干预措施，改善儿童的整体健康和质量。 中风后的生活。据估计，75%的中风幸存者患有心血管并发症， 条件和心血管容量显着有限。许多研究表明，心血管 中风后的健康状况与独立功能不相称， 残疾。残疾的发生使中风幸存者难以从事体力活动， 他们仍然久坐不动，非常不活跃，从而形成了残疾-不活动-贫穷的恶性循环。 心血管健康训练即使在干预后，大多数卒中幸存者的VO 2峰值水平仍低于 建议独立生活所需的最低限度。因此，有必要测试新的干预措施， 导致中风后心血管健康和行走功能的更大改善。之间 对于患有心血管疾病的人，最近的研究发现了一种高强度的间歇训练计划 （HIIT）是安全的，更有效的刺激，改善心血管健康和健康相比， 传统的有氧训练项目。HIIT计划的有效性尚未在患有 慢性中风，但鉴于在其他人群中的成功，这是一个有希望的干预研究，在这一点上， 组因此，本提案的主要目的是测试HIIT计划是否会导致更大的 与标准有氧训练计划相比， 慢性中风第二个目标是：a）测试HIIT计划是否可以导致更大的 与标准有氧训练计划相比，步行功能和活动有所改善，以及B）测试是否 心血管健康的改善和现实世界的身体活动是相关联的。采用随机 对照实验设计，53名慢性（> 6个月）卒中幸存者将接受12周的HIIT 一个标准的有氧跑步机训练计划或12周。主要和次要结局 心血管健康和健身以及步行活动的评估将由设盲评价者在 开始治疗（基线）和末次治疗后立即（基线后12周）。预期 这种新的干预措施的积极作用将为运动训练的建议提供理论基础， 将有氧训练与旨在改善慢性中风的干预措施相结合的大型研究的数据 中风后的日常身体活动。