The MesoCase Study: Mesothelioma Case-Control and Rapid Case Ascertainment Study

MesoCase 研究：间皮瘤病例对照和快速病例查明研究

• 批准号: 10315131
• 负责人: Sheiphali Arvind Gandhi
• 金额: $ 8.16万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-12-28 至 2023-06-27
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10315131
• 关键词: MesoCase; Study; Mesothelioma; Case; Control

Project Summary/Abstract Despite steep declines in asbestos usage since the 1970s, the burden of mesothelioma within the United States has not decreased proportionately. The lack of decline is particularly pronounced among women, in whom mesothelioma rates have remained stable for more than three decades. Although the relationship between occupational asbestos exposure and mesothelioma is well-described, our understanding of non- occupational risk factors is limited. Current lags in the cancer registry network enrollment contribute to delayed patient identification, preventing early intervention. Due to delayed patient identification, previous studies primarily relied on unvalidated proxy interviews for risk exposure assessment. In this project, I will collaborate with the California Department of Public Health's Occupational Health Branch (OHB) and the California Cancer Registry (CCR) to create a novel case ascertainment system in order to mitigate these issues. This study's central objective is to use rapid case ascertainment and exposure assessment to elucidate non-occupational asbestos exposures that are associated with the development of mesothelioma. To assess this, I will conduct a case-control study to determine the non-occupational exposures to asbestos utilizing a novel case ascertainment strategy (Aim 1). The secondary objective of this study is to assess the feasibility of creating a rapid mesothelioma case ascertainment program that could facilitate future research and treatment (Aim 2). A rapid cancer-reporting system will create a mechanism for rapid exposure assessments within the public health surveillance system, allowing us to assess cancer risk factors accurately. The proposal is directly responsive to NHLBI's Strategic Vision to "develop and optimize clinical and implementation research to improve health and reduce disease" (Objective 6). Additionally, by developing innovative approaches to integrate multiple forms of data such as natural language processing, exposure history questionnaires, registry metadata, geo-mapping, exposure assessments, and outcome data, our project also fulfills the goal of "leverag[ing] emerging opportunities in data science to open new frontiers in HLBS research" (Objective 7). Through improved public health surveillance and risk assessment, exposures can be mitigated, bolstering cancer prevention efforts. This is particularly important to elucidating the preventable, non-occupational asbestos exposures related to mesothelioma. Furthermore, this award will serve as a foundation for training Dr. Sheiphali Gandhi, a fellow at the University of California San Francisco, to prepare her for her academic research career. This fellowship will provide her with the necessary support to hone her epidemiology and biostatistical skills in order to become an independent physician-scientist studying the epidemiology of occupational and environmental lung diseases.

项目总结/摘要 尽管自20世纪70年代以来石棉使用量急剧下降，但美国间皮瘤的负担 国家并没有按比例减少。这种情况在妇女中尤为明显， 其中间皮瘤率保持稳定超过三十年。关系虽 之间的职业石棉暴露和间皮瘤是很好的描述，我们的理解，非- 职业危险因素有限。目前癌症登记网络登记的滞后导致延迟 患者识别，防止早期干预。由于患者识别延迟，之前的研究 主要依靠未经验证的代理访谈进行风险暴露评估。在这个项目中，我将与 与加州公共卫生部职业健康分支（OHB）和加州癌症中心合作， 注册处（CCR）创建一个新型案件查明系统，以缓解这些问题。这项研究的 中心目标是使用快速病例确定和暴露评估来阐明非职业性 石棉暴露与间皮瘤的发展有关。为了评估这一点，我将进行一次 利用一例新病例确定非职业性石棉暴露的病例对照研究 战略目标（Aim 1）本研究的第二个目的是评估建立一个 快速间皮瘤病例确定计划，可以促进未来的研究和治疗（目标2）。一 癌症快速报告系统将在公共卫生领域建立一个快速暴露评估机制 监测系统，使我们能够准确评估癌症风险因素。该提案直接回应了 NHLBI的战略愿景是“开发和优化临床和实施研究，以改善健康和 减少疾病”（目标6）。此外，通过开发创新方法， 数据，如自然语言处理，接触历史调查问卷，登记册元数据，地理映射， 暴露评估和结果数据，我们的项目还实现了“监测新兴 数据科学的机遇，以开辟HLBS研究的新领域”（目标7）。通过改善公共 通过健康监测和风险评估，可以减轻暴露，加强癌症预防工作。这 特别重要的是阐明可预防的，非职业性石棉暴露有关， 间皮瘤此外，该奖项将作为培训Sheiphali Gandhi博士的基础， 加州圣弗朗西斯科大学，为她的学术研究生涯做准备。该奖学金将 为她提供必要的支持，以磨练她的流行病学和生物统计技能，以成为一个 研究职业和环境肺病流行病学的独立医生兼科学家。