Study of tumor suppressor genes on malignant mesothelioma, focusing on ATBF1 gene

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ATBF1 was weakly positive for non-neoplastic mesothelial cells. In mesothelioma cells, ATBF1 was mostly positive in the cytoplasm. Nuclear staining of ATBF1 was seen with reactive mesothelial cells and a part of mesothelioma cells that localized at the surface on the pleura. After using drugs inhibiting cell growth, some mesothelial cells showed weak nuclear staining of ATBF1. From these findings, there may be some relationship between cell growth and proliferation of mesothelioma cells and the intracellular localization of ATBF1. However, the significance and mechanisms of intracellular localization of ATBF1 are still not clear.