Addressing Tetrachloroethylene Exposure in an Impacted Community: Residents' Concerns, Neurotoxic Effects, and Exposure Reduction

解决受影响社区的四氯乙烯暴露问题：居民的担忧、神经毒性作用和减少暴露

• 批准号: 10312448
• 负责人: SA LIU
• 金额: $ 61.37万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-12 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10312448
• 关键词: Address; Adult; Assessment tool; Authorization documentation; Awareness; Biological; Breathing; Carbon; Cognitive; Communities; Community Health; County; Data; Data Analyses; Decision Making; Development; Disadvantaged; Education; Effectiveness; Environmental Health; Evaluation; Excision; Exhalation; Exposure to; Filtration; Focus Groups; Goals; Group Interviews; Hazardous Waste Sites; Health; Health Status; Home; Incidence; Indiana; Individual; Indoor Air Pollution; Industrialization; Industry; Information Centers; Investigation; Legal; Legal Liability; Linear Regressions; Link; Malignant Neoplasms; Measures; Metals; Methodology; Modeling; Multimedia; Municipalities; Neurocognitive; Occupational Exposure; Pathway interactions; Perception; Persons; Poison; Process; Property; Protons; Public Health; Reaction Time; Recording of previous events; Reporting; Research; Resources; Risk; Risk Assessment; Sampling; Site; Soil; Solvents; Surveys; System; Testing; Tetrachloroethylene; Theory of Change; Time; Trichloroethylene; United States Environmental Protection Agency; Vision; Visual; Waste Management; Water; Work; base; cancer risk; citizen science; cognitive function; community engaged research; community living; data registry; design; disease registry; drinking water; effectiveness evaluation; environmental justice; evidence base; exposed human population; ground water; home test; improved; indoor air; mass spectrometer; member; migration; minimal risk; neoplasm registry; neurotoxic; neurotoxicity; operation; primary endpoint; programs; recruit; remediation; response; success; superfund site; tool; vapor intrusion; volatile organic compound

Project Summary We propose to develop a community engaged research program in Martinsville, IN, a community of 11,000 people that overlays four groundwater contamination sites, including a U.S. Environmental Protection Agency- designated Superfund site. The total size of the groundwater contamination is over 60 acres and lies within a single aquifer. The contaminants are chlorinated volatile organic compounds (CVOCs), primarily tetrachloroethylene (PCE) and trichloroethylene (TCE), thought to originate from several dry cleaning and metal degreasing operations. An activated carbon filtration system has been in operation since 2005 to remove PCE/COVCs from the municipal water, which now meets EPA drinking water standards. However, a recent report from the Agency for Toxic Substances and Disease Registry concludes that people’s health may be harmed by breathing indoor air contaminated via vapor intrusion, the migration of volatile compounds from contaminated groundwater and soil into buildings above. The long-term goal of our research is to understand health effects of PCE exposure in communities, and to empower community members’ participation in environmental health decision-making. The project will be led by a transdisciplinary academic team in a strong partnership with two community based organizations. This team will partner with an existing, engaged Community Advisory Board (CAB), to accomplish three aims. Aim 1 will assess the community’s concerns and perceptions about the contamination and associated health risks, and how that changes across the 5-year project. Aim 2 will quantify current exposure to PCE/CVOCs in exhaled breath and indoor air from 300 residents using a cutting edge assessment tool, proton transfer reaction time-of-flight mass spectrometer (PTR-TOF-MS). Through modeling we will estimate cumulative exposures in residents and investigate associations of CVOC mixtures with visual and cognitive functions, which are hypothesized to be a sensitive non-cancer endpoint for PCE exposure. We will also address the community’s concerns about elevated cancer rates using Indiana state cancer registry data. In Aim 3, we will design and implement a targeted educational campaign to promote PCE/CVOC testing and installation of mitigation systems when residential contamination levels exceed exposure limits, with a focus on promoting property owners’ and landlords’ participation in vapor intrusion testing and remediation activities. With the CAB, we will co-design the action plan, identifying and responding to emerging barriers, through a Developmental Evaluation (DE) process utilizing a Theory of Change (TOC) model informed by the evaluation team’s qualitative and quantitative analysis of data on stakeholder concerns and responses. Throughout the process of community assessment and education, we will evaluate the effectiveness of the process, identifying pathways for moving from research to effective actions.

项目概要 我们建议在印第安纳州马丁斯维尔（一个拥有 11,000 人的社区）开发一个社区参与研究计划 人们覆盖了四个地下水污染地点，其中包括美国环境保护局- 指定的超级基金网站。地下水污染总面积超过60英亩，位于 单一含水层。污染物主要是氯化挥发性有机化合物 (CVOC) 四氯乙烯 (PCE) 和三氯乙烯 (TCE)，被认为源自多次干洗和清洗 金属除油作业。自 2005 年以来，活性炭过滤系统一直在运行，以去除 来自市政供水的四氯乙烯/COVC，现已符合 EPA 饮用水标准。然而，最近的一则 有毒物质和疾病登记局的报告得出的结论是，人们的健康可能会受到影响 呼吸被蒸气侵入污染的室内空气、挥发性化合物的迁移而受到伤害 受污染的地下水和土壤进入上面的建筑物。我们研究的长期目标是了解 社区中四氯乙烯暴露对健康的影响，并增强社区成员参与 环境健康决策。该项目将由一支实力雄厚的跨学科学术团队领导 与两个社区组织建立伙伴关系。该团队将与现有的、积极参与的团队合作 社区咨询委员会（CAB），以实现三个目标。目标 1 将评估社区的担忧并 对污染和相关健康风险的看法，以及五年内的变化 项目。目标 2 将量化当前 300 米呼出气和室内空气中 PCE/CVOC 的暴露量 居民使用尖端评估工具，质子转移反应飞行时间质谱仪 (PTR-TOF-MS)。通过建模，我们将估计居民的累积暴露量并进行调查 CVOC 混合物与视觉和认知功能的关联，假设这是一种敏感的 四氯乙烯暴露的非癌症终点。我们还将解决社区对癌症发病率上升的担忧 使用印第安纳州癌症登记数据的比率。在目标3中，我们将设计并实施有针对性的教育 开展住宅污染时促进 PCE/CVOC 测试和缓解系统安装的活动 水平超过暴露限制，重点是促进业主和房东参与蒸气 入侵测试和修复活动。我们将与 CAB 共同设计行动计划，确定并 通过利用理论的发展评估（DE）过程来应对新出现的障碍 评估团队对数据进行定性和定量分析得出的变化（TOC）模型 利益相关者的关切和回应。在社区评估和教育的整个过程中，我们 将评估该过程的有效性，确定从研究转向有效的途径 行动。