Fast and accurate self-monitoring tests for better adherence to exercise and diet

快速准确的自我监测测试，以更好地坚持运动和饮食

• 批准号: 10046930
• 金额: $ 6.01万
• 依托单位: DAINOMICS LTD
• 依托单位国家: 英国
• 项目类别: Grant for R&D
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=10046930
• 关键词: Fast; accurate; self; monitoring; tests

Lifestyle diseases arise through prolonged exposure to health risks caused by mainly three avoidable behaviours: smoking, unhealthy diet, and physical inactivity. Resulting illnesses, such as stroke, diabetes, heart attack, or lung cancer result in a loss of quality of life for the individual, but also in a significant portion of all deaths and huge healthcare and economic costs.Despite the underlying behaviours being entirely avoidable, many individuals find changing them hard or even impossible. One of the reasons for this difficulty lies in the long-term nature (months to years) of health improvements to manifest themselves, in other words, what is missing is a timely (hours to days) positive and motivating feedback loop to see the effects of behavioural change efforts.Changing unhealthy eating habits, for example, will not normally result in significant weight loss for several months (ignoring potentially unhealthy crash diets). Similarly, starting a regime of exercises will not yield significant improvements to either physique, strength, or aerobic fitness for a long time (depending on the exercises chosen and the intensity and duration of them).This project will use published knowledge about molecules in blood and saliva, which can reflect the state of the body with respect to nutrition and exercise. One such biomarker was prominently used in Dr Mosley's Horizon documentary on fasting diets ([https://www.bbc.co.uk/iplayer/episode/b01lxyzc/horizon-20122013-3-eat-fast-and-live-longer][0])The project will use already identified detection reagents that only need adaptation to function in self-administered Lateral Flow Test (LFT) with which we all had to become familiar during the pandemic. The anticipated results are easy to use and interpret LFTs which can measure the effect on the body in hours to a few days after starting a diet or an exercise regime. Results can be used to celebrate successful lifestyle change long before changes to weight or fitness could be measured. They can also be used to optimize and compare different diets or exercises, greatly adding to the empowerment of individuals regarding their lifestyle changes.After the pandemic, custom LFT manufacturing became much cheaper and our LFT products can therefore be made very affordable. But even a minor uptake of the proposed tests to improve the success of lifestyle changes would have an enormously positive effect on individuals, society, and UK finances - given that 20% of the population is classified as obese and that over 1 million hospital admissions per year (2020 NHS data) were related to obesity.[0]: https://www.bbc.co.uk/iplayer/episode/b01lxyzc/horizon-20122013-3-eat-fast-and-live-longer

生活方式疾病是由于长期接触主要由三种可避免的行为造成的健康风险而产生的：吸烟、不健康的饮食和缺乏身体活动。由此产生的疾病，如中风、糖尿病、心脏病发作或肺癌，会导致个人生活质量下降，但也占所有死亡人数的很大一部分，并造成巨大的医疗保健和经济成本。尽管潜在的行为是完全可以避免的，但许多人发现改变它们很难，甚至是不可能的。造成这种困难的原因之一在于健康改善的长期性（数月至数年），换句话说，缺少的是一个及时的（数小时至数天）积极和激励的反馈循环，以看到行为改变努力的效果。例如，改变不健康的饮食习惯通常不会在几个月内导致显著的体重减轻（忽略潜在的不健康的速成饮食）。同样地，开始一种锻炼方式在很长一段时间内（取决于所选择的锻炼方式及其强度和持续时间）不会对体格、力量或有氧健身产生显著的改善。该项目将使用已发表的关于血液和唾液分子的知识，这些知识可以反映身体在营养和运动方面的状态。其中一种生物标志物在莫斯利博士关于禁食饮食的纪录片《地平线》中得到了突出的应用（[https://www.bbc.co.uk/iplayer/episode/b01lxyzc/horizon-20122013-3-eat-fast-and-live-longer][0]）The]项目将使用已经确定的检测试剂，这些试剂只需要适应在大流行期间我们都必须熟悉的自我管理的侧流测试（LFT）中发挥作用。预期的结果很容易使用和解释LFTs，它可以在开始节食或锻炼后的几小时到几天内测量对身体的影响。结果可以用来庆祝成功的生活方式的改变，早在体重或健康的变化可以测量。它们还可以用来优化和比较不同的饮食或运动，极大地增加了个人改变生活方式的能力。疫情爆发后，定制LFT制造成本大大降低，因此我们的LFT产品价格非常亲民。但是，考虑到20%的人口被归类为肥胖，而且每年有超过100万的住院患者（2020年NHS的数据）与肥胖有关，即使是很小程度地采用拟议的测试来提高生活方式改变的成功率，也会对个人、社会和英国的财政产生巨大的积极影响。[0]: https://www.bbc.co.uk/iplayer/episode/b01lxyzc/horizon - 20122013 - 3 -吃-快- - - -活更长