Fast and accurate self-monitoring tests for better adherence to exercise and diet

生活方式疾病是由于长期暴露在健康风险中而引起的，这些风险主要由三种可避免的行为引起：吸烟、不健康的饮食和缺乏运动。随之而来的疾病，如中风、糖尿病、心脏病发作或肺癌，会导致个人生活质量的下降，但也会导致很大一部分死亡以及巨大的医疗和经济成本。尽管潜在的行为是完全可以避免的，但许多人发现很难甚至不可能改变它们。造成这种困难的原因之一在于健康改善的长期性(几个月到几年)，换句话说，缺少一个及时的(几个小时到几天)积极的和激励的反馈循环，看看行为改变的效果。例如，改变不健康的饮食习惯通常不会在几个月内导致显著的体重下降(忽略潜在的不健康的速成饮食)。同样，在很长一段时间内(取决于所选择的运动以及运动的强度和持续时间)，开始一项运动计划不会对体格、力量或有氧适应能力产生显著的改善。这个项目将使用已发表的关于血液和唾液中分子的知识，这些知识可以反映身体在营养和运动方面的状态。在莫斯利博士关于禁食饮食的地平线纪录片中，一个这样的生物标志物被显著使用，([https://www.bbc.co.uk/iplayer/episode/b01lxyzc/horizon-20122013-3-eat-fast-and-live-longer][0])The项目将使用已经确定的检测试剂，这些试剂只需要适应就可以在自我管理的侧向流动测试中发挥作用，我们都必须在大流行期间熟悉这种测试。预期的结果很容易使用和解释LFT，它可以在开始节食或锻炼后的几个小时到几天内测量对身体的影响。结果可以用来庆祝成功的生活方式改变，早在体重或健康的变化可以被测量之前。它们还可以用来优化和比较不同的饮食或锻炼，极大地增强了个人对生活方式变化的能力。在大流行之后，定制的LFT制造变得便宜得多，因此我们的LFT产品可以非常实惠。但是，考虑到20%的人口被归类为肥胖症，以及每年有100多万人入院治疗(英国国民健康保险制度的数据)与肥胖有关，即使是少量采用拟议的测试来改善生活方式的成功，也会对个人、社会和英国的财政产生巨大的积极影响。[0]：https://www.bbc.co.uk/iplayer/episode/b01lxyzc/horizon-20122013-3-eat-fast-and-live-longer：

Lifestyle diseases arise through prolonged exposure to health risks caused by mainly three avoidable behaviours: smoking, unhealthy diet, and physical inactivity. Resulting illnesses, such as stroke, diabetes, heart attack, or lung cancer result in a loss of quality of life for the individual, but also in a significant portion of all deaths and huge healthcare and economic costs.Despite the underlying behaviours being entirely avoidable, many individuals find changing them hard or even impossible. One of the reasons for this difficulty lies in the long-term nature (months to years) of health improvements to manifest themselves, in other words, what is missing is a timely (hours to days) positive and motivating feedback loop to see the effects of behavioural change efforts.Changing unhealthy eating habits, for example, will not normally result in significant weight loss for several months (ignoring potentially unhealthy crash diets). Similarly, starting a regime of exercises will not yield significant improvements to either physique, strength, or aerobic fitness for a long time (depending on the exercises chosen and the intensity and duration of them).This project will use published knowledge about molecules in blood and saliva, which can reflect the state of the body with respect to nutrition and exercise. One such biomarker was prominently used in Dr Mosley's Horizon documentary on fasting diets ([https://www.bbc.co.uk/iplayer/episode/b01lxyzc/horizon-20122013-3-eat-fast-and-live-longer][0])The project will use already identified detection reagents that only need adaptation to function in self-administered Lateral Flow Test (LFT) with which we all had to become familiar during the pandemic. The anticipated results are easy to use and interpret LFTs which can measure the effect on the body in hours to a few days after starting a diet or an exercise regime. Results can be used to celebrate successful lifestyle change long before changes to weight or fitness could be measured. They can also be used to optimize and compare different diets or exercises, greatly adding to the empowerment of individuals regarding their lifestyle changes.After the pandemic, custom LFT manufacturing became much cheaper and our LFT products can therefore be made very affordable. But even a minor uptake of the proposed tests to improve the success of lifestyle changes would have an enormously positive effect on individuals, society, and UK finances - given that 20% of the population is classified as obese and that over 1 million hospital admissions per year (2020 NHS data) were related to obesity.[0]: https://www.bbc.co.uk/iplayer/episode/b01lxyzc/horizon-20122013-3-eat-fast-and-live-longer