Impact of Lifestyle on Cardiovascular and Metabolic Risk Factors in Trauma Exposed Post-9/11 Veterans

生活方式对 9/11 后遭受创伤的退伍军人心血管和代谢危险因素的影响

• 批准号: 10316581
• 负责人: James W Whitworth
• 金额: --
• 依托单位: VA BOSTON HEALTH CARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-11-01 至 2026-10-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10316581
• 关键词: Accelerometer; Address; Affect; Blood Glucose; Blood Pressure; Body mass index; Boston; Cardiometabolic Disease; Cardiovascular Diseases; Cardiovascular system; Caring; Cause of Death; Center for Translational Science Activities; Clinical; Collection; Cross-Sectional Studies; Data; Development; Diabetes Mellitus; Diagnosis; Diet; Dietary intake; Dyslipidemias; Eating; Exercise; Family; Fibrinogen; Future; Glucose; Health; Healthcare Systems; Heart Diseases; Hypertension; Individual; Intervention; K-Series Research Career Programs; Lead; Life Style; Link; Lipids; Longitudinal Studies; Longitudinal cohort study; Measurement; Measures; Mediating; Mentorship; Metabolic; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Oxygen; Participant; Pathway interactions; Patient Self-Report; Physical activity; Post-Traumatic Stress Disorders; Premature Mortality; Prevention; Provider; Rehabilitation therapy; Research; Risk; Risk Factors; Series; Severities; Skeletal Muscle; Symptoms; Therapeutic Effect; Time; Training; Unhealthy Diet; United States; Veterans; active lifestyle; blood glucose regulation; blood lipid; blood pressure reduction; cardiometabolic risk; cardiometabolism; cardiorespiratory fitness; career; cohort; dietary; disability; disability risk; exercise rehabilitation; good diet; heart disease risk; improved; lifestyle factors; lifestyle intervention; modifiable lifestyle factors; mortality; novel; physical inactivity; post 9/11; post-trauma exposure; sedentary; sedentary activity; stress disorder; stress related disorder

Cardiometabolic disease (e.g., type 2 diabetes or cardiovascular disease) is a leading cause of disability and mortality in the United States, and especially so among Veterans. Posttraumatic stress disorder (PTSD) – a salient health concern for many Veterans and their families – is linked to an increased risk of cardiometabolic disease and premature mortality. The precise mechanisms of this relationship are not fully understood. However, recent research suggests that a diagnosis of PTSD increases the risk for hypertension, dyslipidemia and obesity, all of which are known predictors of cardiometabolic disease. A better understanding of what modifiable factors (e.g., lifestyle) influence the link between PTSD and cardiometabolic health and functioning will aid in the development of novel rehabilitative nonpharmacological interventions (e.g., exercise) for cardiometabolic disease and disability in Veterans with PTSD. Physical activity (PA) and diet are promising examples of modifiable lifestyle factors. For instance, regular PA and a healthy diet strongly reduce the risk for cardiometabolic disease through numerous pathways, such as reductions in blood pressure, blood lipids, adiposity, and by promoting blood glucose control. Simply put, 80% of all new cases of type 2 diabetes are attributed to physical inactivity and poor diet. Low cardiorespiratory fitness (CRF) is also a critical factor in the risk for disability and mortality due to cardiovascular disease. Despite the clear value and potential impact, there is little research examining relationships between PA and diet, cardiometabolic health, and functioning in Veterans with PTSD. This is a critical research gap. Physical inactivity and poor diet increase the risk of cardiometabolic disease and PTSD likely compounds this risk. Veterans with PTSD often lead sedentary lives and make unhealthy dietary choices placing them in a perfect storm for developing cardiometabolic disease and related disability. The purpose of this project is to examine the influence of several modifiable yet understudied lifestyle factors (i.e., PA and diet quality) on indicators of cardiometabolic health, and functioning in post-9/11 Veterans. The aims of this project are: Aim 1: To examine PA participation as a mechanism linking PTSD to cardiometabolic health and functioning in post-9/11 Veterans. I will longitudinally assess associations between PTSD diagnosis, PA, cardiometabolic health, and functioning over time in 250 TRACTS participants. H1-1: Total self-report PA will mediate the effects of PTSD on cardiometabolic health and functioning over time, such that lower PA will increase the detrimental effect of PTSD on cardiometabolic health and functioning. H1-2: PA intensity will moderate the effect physical activity has on cardiometabolic health and functioning. Supplemental Aim 1A: To validate the use of a self-report clinical measure of PA against objective measure obtained via accelerometry. Objective measurement of PA is not often accessible or feasible for VA providers (e.g., time constraints). It is essential that quick self-report PA measures accurately reflect the PA of Veterans. I will compare data from a self-report clinical PA measure to objectively measured PA/sedentary time (i.e., accelerometry), CRF, cardiometabolic health, functioning, and PTSD symptom severity in 100 post-9/11 Veterans. H1A-1: Self-report and objective measurement of PA will be significantly correlated. H1A-2: Both self-report and objectively measured PA/sedentary time will be associated with CRF, cardiometabolic health, functioning, and PTSD symptom severity. Aim 2: To examine diet quality as a mechanism linking PTSD to cardiometabolic health and functioning in post-9/11 Veterans. I will longitudinally assess associations between PTSD diagnosis, diet quality, cardiometabolic health, and functioning over time in 200 TRACTS participants. H2: Self-report dietary intake will mediate the effects of PTSD on cardiometabolic health and functioning over time, such that a poor diet will increase the detrimental effect of PTSD on cardiometabolic health and functioning.

Cardiometabolic disease (e.g., type 2 diabetes or cardiovascular disease) is a leading cause of disability and mortality in the United States, and especially so among Veterans. Posttraumatic stress disorder (PTSD) – a salient health concern for many Veterans and their families – is linked to an increased risk of cardiometabolic disease and premature mortality. The precise mechanisms of this relationship are not fully understood. However, recent research suggests that a diagnosis of PTSD increases the risk for hypertension, dyslipidemia and obesity, all of which are known predictors of cardiometabolic disease. A better understanding of what modifiable factors (e.g., lifestyle) influence the link between PTSD and cardiometabolic health and functioning will aid in the development of novel rehabilitative nonpharmacological interventions (e.g., exercise) for cardiometabolic disease and disability in Veterans with PTSD. Physical activity (PA) and diet are promising examples of modifiable lifestyle factors. For instance, regular PA and a healthy diet strongly reduce the risk for cardiometabolic disease through numerous pathways, such as reductions in blood pressure, blood lipids, adiposity, and by promoting blood glucose control. Simply put, 80% of all new cases of type 2 diabetes are attributed to physical inactivity and poor diet. Low cardiorespiratory fitness (CRF) is also a critical factor in the risk for disability and mortality due to cardiovascular disease. Despite the clear value and potential impact, there is little research examining relationships between PA and diet, cardiometabolic health, and functioning in Veterans with PTSD. This is a critical research gap. Physical inactivity and poor diet increase the risk of cardiometabolic disease and PTSD likely compounds this risk. Veterans with PTSD often lead sedentary lives and make unhealthy dietary choices placing them in a perfect storm for developing cardiometabolic disease and related disability. The purpose of this project is to examine the influence of several modifiable yet understudied lifestyle factors (i.e., PA and diet quality) on indicators of cardiometabolic health, and functioning in post-9/11 Veterans. The aims of this project are: Aim 1: To examine PA participation as a mechanism linking PTSD to cardiometabolic health and functioning in post-9/11 Veterans. I will longitudinally assess associations between PTSD diagnosis, PA, cardiometabolic health, and functioning over time in 250 TRACTS participants. H1-1: Total self-report PA will mediate the effects of PTSD on cardiometabolic health and functioning over time, such that lower PA will increase the detrimental effect of PTSD on cardiometabolic health and functioning. H1-2: PA intensity will moderate the effect physical activity has on cardiometabolic health and functioning. Supplemental Aim 1A: To validate the use of a self-report clinical measure of PA against objective measure obtained via accelerometry. Objective measurement of PA is not often accessible or feasible for VA providers (e.g., time constraints). It is essential that quick self-report PA measures accurately reflect the PA of Veterans. I will compare data from a self-report clinical PA measure to objectively measured PA/sedentary time (i.e., accelerometry), CRF, cardiometabolic health, functioning, and PTSD symptom severity in 100 post-9/11 Veterans. H1A-1: Self-report and objective measurement of PA will be significantly correlated. H1A-2: Both self-report and objectively measured PA/sedentary time will be associated with CRF, cardiometabolic health, functioning, and PTSD symptom severity. Aim 2: To examine diet quality as a mechanism linking PTSD to cardiometabolic health and functioning in post-9/11 Veterans. I will longitudinally assess associations between PTSD diagnosis, diet quality, cardiometabolic health, and functioning over time in 200 TRACTS participants. H2: Self-report dietary intake will mediate the effects of PTSD on cardiometabolic health and functioning over time, such that a poor diet will increase the detrimental effect of PTSD on cardiometabolic health and functioning.