A Small Molecule That Blocks Salmonella Replication in Macrophages
阻止沙门氏菌在巨噬细胞中复制的小分子
基本信息
- 批准号:10312125
- 负责人:
- 金额:$ 19.25万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-12-07 至 2023-11-30
- 项目状态:已结题
- 来源:
- 关键词:AffectAnti-Bacterial AgentsBacteriaBiologicalBiologyCell membraneCellsChemicalsColony-forming unitsConstitutionDataDevelopmentDoseEukaryotic CellFutureGrowthInfectionLeadLightingLipidsLiposomesMammalian CellMeasurementMembraneMembrane BiologyMembrane FluidityMicroscopyMolecularMonitorMorbidity - disease rateMorphologyMusPhagosomesPharmaceutical PreparationsPropertyRespirationSalmonellaSalmonella typhimuriumSpleenStructureTestingToxic effectTransmission Electron Microscopyantimicrobialbasedrug developmentexperimental studyfluorescence imaginghuman pathogenimprovedin vivomacrophagemitochondrial membranemortalitynovel strategiespathogenpathogenic bacteriapathogenic microbepreferencepreventscreeningsmall moleculetoolvesicular releasevoltage
项目摘要
PROJECT SUMMARY
How microbial pathogens evade host cellular defenses remains unclear. A full molecular
understanding of host-pathogen interactions will aid in the development of new approaches to treat
infection. There is a particular need to identify new classes of chemicals that target Gram-negative
human pathogens. We therefore developed an in-cell, high content microscopy-based screening
platform (called SAFIRE) that identifies compounds which prevent the accumulation of GFP-
expressing Salmonella enterica serovar Typhimurium (S. Typhimurium) in macrophages. We are
now at the stage of establishing compound mechanism of action, including defining why compounds
enable the macrophage to survive while the bacterium is killed. The compound we propose to study,
JD1, is not sufficiently developed to be a lead compound for drug development but is instead at the
stage of basic biological discovery. These efforts may reveal new facets of host-pathogen biology,
new targets for Gram-negative bacterial pathogens, and possibly identify a chemical that could be
improved for use as an antimicrobial.
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项目总结
项目成果
期刊论文数量(0)
专著数量(0)
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会议论文数量(0)
专利数量(0)
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Corrella S Detweiler其他文献
Corrella S Detweiler的其他文献
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{{ truncateString('Corrella S Detweiler', 18)}}的其他基金
Infection-Dependent Vulnerabilities of Gram-negative Bacterial Pathogens
革兰氏阴性细菌病原体的感染依赖性脆弱性
- 批准号:
10592676 - 财政年份:2023
- 资助金额:
$ 19.25万 - 项目类别:
Using Salmonella Pathogenesis and Cell Biology as a Discovery Tool
使用沙门氏菌发病机制和细胞生物学作为发现工具
- 批准号:
10665946 - 财政年份:2023
- 资助金额:
$ 19.25万 - 项目类别:
Chemical Probes for Bacteria-Macrophage Interactions
用于细菌-巨噬细胞相互作用的化学探针
- 批准号:
9171993 - 财政年份:2016
- 资助金额:
$ 19.25万 - 项目类别:
Macrophages, Granulomas, and Bacterial Persistence
巨噬细胞、肉芽肿和细菌持久性
- 批准号:
9277403 - 财政年份:2016
- 资助金额:
$ 19.25万 - 项目类别:
A Novel Screen for Antibacterials that Are Non-Toxic to Mammals
一种对哺乳动物无毒的抗菌药物的新型筛选
- 批准号:
9186486 - 财政年份:2015
- 资助金额:
$ 19.25万 - 项目类别:
A Novel Screen for Antibacterials that Are Non-Toxic to Mammals
一种对哺乳动物无毒的抗菌药物的新型筛选
- 批准号:
9015218 - 财政年份:2015
- 资助金额:
$ 19.25万 - 项目类别:
Host Pathways that Enable /Salmonella/ Replication Within Hemophagocytic Macropha
使/沙门氏菌/在噬血细胞巨噬细胞内复制的宿主途径
- 批准号:
8281809 - 财政年份:2012
- 资助金额:
$ 19.25万 - 项目类别:
Host Pathways that Enable /Salmonella/ Replication Within Hemophagocytic Macropha
使/沙门氏菌/在噬血细胞巨噬细胞内复制的宿主途径
- 批准号:
8418684 - 财政年份:2012
- 资助金额:
$ 19.25万 - 项目类别:
Hemophagocytic Macrophages and Systemic Salmonella Infection
噬血细胞巨噬细胞和全身性沙门氏菌感染
- 批准号:
8805824 - 财政年份:2012
- 资助金额:
$ 19.25万 - 项目类别:
Hemophagocytic Macrophages and Systemic Salmonella Infection
噬血细胞巨噬细胞和全身性沙门氏菌感染
- 批准号:
8433309 - 财政年份:2012
- 资助金额:
$ 19.25万 - 项目类别:
相似海外基金
New technologies for targeted delivery of anti-bacterial agents
抗菌药物靶向递送新技术
- 批准号:
1654774 - 财政年份:2015
- 资助金额:
$ 19.25万 - 项目类别:
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针对细菌磷酸酶的新型抗菌剂。
- 批准号:
8416313 - 财政年份:2012
- 资助金额:
$ 19.25万 - 项目类别:
Targeting bacterial phosphatases for novel anti-bacterial agents.
针对细菌磷酸酶的新型抗菌剂。
- 批准号:
8298885 - 财政年份:2012
- 资助金额:
$ 19.25万 - 项目类别: