Understanding Ecologic Stress, Risk and Health Resiliencies in Mexican-Origin Adults Living in a High Poverty Rural Community
了解生活在高度贫困农村社区的墨西哥裔成年人的生态压力、风险和健康弹性
基本信息
- 批准号:10312808
- 负责人:
- 金额:$ 59.45万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-04-13 至 2023-12-31
- 项目状态:已结题
- 来源:
- 关键词:AcculturationAdultAgeAmerican Heart AssociationAnxietyArizonaBehavior TherapyBehavioralBiologicalBiological MarkersBloodBlood PressureBody mass indexBorder CommunityCardiovascular DiseasesCardiovascular systemCholesterolChronic DiseaseChronic stressClinicalClinical TrialsCohort AnalysisCommunitiesCommunity ActionsConnecticutCoping SkillsCountyDataData AnalysesData CollectionDiabetes MellitusDietEnvironmentEthnographyEvaluationExposure toFocus GroupsHairHealthHouseholdHydrocortisoneIndividualInflammationInflammatory ResponseInterventionInterviewKeratinKnowledgeLatinoLatino PopulationLeadLengthLifeLow incomeMalignant NeoplasmsMeasuresMediator of activation proteinMental DepressionMental disordersMethodsMexicanModelingNail plateObesityParticipantPatient Self-ReportPatternPersonsPhysical activityPhysiologicalPopulationPrevention ResearchPrevention trialProcessReportingResearchResearch Project GrantsResourcesRiskRisk FactorsRural CommunitySalivaSamplingSeriesSerumSmokingSocial supportSourceSpottingsStressSubgroupSurveysTarget PopulationsTestingUrinecohortcommunity based participatory researchcommunity centercopingdisorder riskexperiencehealth disparityimmune functioninflammatory markerinformantinnovationmedically underservedminimally invasivenovelpopulation basedpredictive markerprotective factorspsychosocialrecruitresiliencerural povertysocialsocial culturestress managementstress reductionstressorsystemic inflammatory responsetrendtrial comparingvulnerable community
项目摘要
Project Summary
Latino adults have higher age-adjusted rates of many chronic disease relative to overall US trends, while also
having health advantages. Exposure to stress contributes to some of these disparities, with implications for
diabetes, cardiovascular disease, cancer, and mental illness. This project will clarify reported stressors
experienced by Mexican-origin adults in a low-income, medically under-served, border community. This
community participatory research will: 1) elucidate our knowledge of stress and culturally-bounded protective
factors through intensive, ethnographically-grounded interviews (N = 50); and, 2) examine relationships
between reported stressors to objective measures of physiological stress, systemic inflammation, and chronic
disease risk. The latter will be achieved through a representative household survey of Mexican-descent adults
(N = 320). Each of two yearly follow ups will assess biomarkers and self-reports on several factors: valid
psychosocial scales (e.g., socially embedded stressors); protective social and culturally-tied factors; and,
culturally-relevant coping resources (e.g., perceived individual support available and persons' openness to
receive support). Objective health metrics include markers of inflammation and systemic dysregulation (i.e.,
hsCRP, Il-6; cortisol) and Life's Simple 7 (i.e., A1c; cholesterol; blood pressure; adiposity; smoking; physical
activity; diet). Longitudinal models will be used to predict biomarker and chronic disease risk, and test for
differential sub-group patterns. Innovative, minimally invasive, and community responsive methods will be
used for biomarker data collection--specifically from dried blood spot, immediately available assessments of
A1c, BMI and BP, and cortisol from hair. Cortisol in hair and nails reflect more chronic stress indicators than
more commonly studied measures, and have particular promise as endpoints in stress management
interventions. Cortisol in keratin samples better parallels expected lengths of behavioral intervention trials
compared with highly transient levels observed in saliva, serum and urine. Analysis of the cohort data will also
directly inform sub-population targeting for a series of focus groups (N = 90). A minimum of 4 groups for each
biologically identified sub-populations will be conducted: those for persons of uniform high stress (high
reported stress and high biologic stress), those of uniform low stress, and those that appear resilient (high in
reported stress but lower than expected biologic stress). The adaptability of a promising stress-management
CHW intervention recently tested with Latinos in Connecticut will be explored. Key informant interviews with
community stakeholders and a community advisory board leveraged from a five-year prevention research
center beginning October of 2019 will further prepare us to submit a clinical trial to reduce and mitigate
stressors. Thus the data generated from this study will be invaluable to conducting a prevention trial to reduce
stress and chronic disease in our community, and in determining methods and models for other populations.
项目总结
项目成果
期刊论文数量(0)
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{{ truncateString('SCOTT C CARVAJAL', 18)}}的其他基金
Understanding Ecologic Stress, Risk and Health Resiliencies in Mexican-Origin Adults Living in a High Poverty Rural Community
了解生活在高度贫困农村社区的墨西哥裔成年人的生态压力、风险和健康弹性
- 批准号:
10543129 - 财政年份:2020
- 资助金额:
$ 59.45万 - 项目类别:
Health Promotion and Disease Prevention Research Centers
健康促进和疾病预防研究中心
- 批准号:
10663104 - 财政年份:2019
- 资助金额:
$ 59.45万 - 项目类别:
Health Promotion and Disease Prevention Research Centers - 2019
健康促进和疾病预防研究中心 - 2019
- 批准号:
10400561 - 财政年份:2019
- 资助金额:
$ 59.45万 - 项目类别:
Health Promotion and Disease Prevention Research Centers - 2019
健康促进和疾病预防研究中心 - 2019
- 批准号:
10441100 - 财政年份:2019
- 资助金额:
$ 59.45万 - 项目类别:
Health Promotion and Disease Prevention Research Centers - 2019
健康促进和疾病预防研究中心 - 2019
- 批准号:
10166351 - 财政年份:2019
- 资助金额:
$ 59.45万 - 项目类别:
Efficacy and Cost Effectiveness of Community Health Worker Models in Addressing Clinical Care and Health Metrics among Under-served Hispanics with Risk Factors for Diabetes
社区卫生工作者模型在解决具有糖尿病危险因素的服务不足的西班牙裔患者的临床护理和健康指标方面的功效和成本效益
- 批准号:
8844199 - 财政年份:2014
- 资助金额:
$ 59.45万 - 项目类别:
Efficacy and Cost Effectiveness of Community Health Worker Models in Addressing Clinical Care and Health Metrics among Under-served Hispanics with Risk Factors for Diabetes
社区卫生工作者模型在解决具有糖尿病危险因素的服务不足的西班牙裔患者的临床护理和健康指标方面的功效和成本效益
- 批准号:
9128415 - 财政年份:2014
- 资助金额:
$ 59.45万 - 项目类别:
Efficacy and Cost Effectiveness of Community Health Worker Models in Addressing Clinical Care and Health Metrics among Under-served Hispanics with Risk Factors for Diabetes
社区卫生工作者模型在解决具有糖尿病危险因素的服务不足的西班牙裔患者的临床护理和健康指标方面的功效和成本效益
- 批准号:
9128378 - 财政年份:2014
- 资助金额:
$ 59.45万 - 项目类别:
Efficacy and Cost Effectiveness of Community Health Worker Models in Addressing Clinical Care and Health Metrics among Under-served Hispanics with Risk Factors for Diabetes
社区卫生工作者模型在解决具有糖尿病危险因素的服务不足的西班牙裔患者的临床护理和健康指标方面的功效和成本效益
- 批准号:
9312670 - 财政年份:2014
- 资助金额:
$ 59.45万 - 项目类别:
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