Integrating social and molecular determinants of HPV-associated cancers

整合 HPV 相关癌症的社会和分子决定因素

• 批准号: 10312815
• 负责人: Angela Liu Mazul
• 金额: $ 12.98万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-06 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10312815
• 关键词: Address; Affect; African American; Anus; Area; Biology; Cancer Biology; Cancer Center; Cancer Etiology; Censuses; Cervical; Clinical; Communities; Complement; Complex; Data; Databases; Demographic Factors; Development; Disease; Epidemiologic Methods; Epidemiology; Genomics; Genotype; Geographic Information Systems; Geography; Goals; HPV oropharyngeal cancer; Health Services Accessibility; Human Papilloma Virus Vaccination; Human Papilloma Virus-Related Malignant Neoplasm; Human Papillomavirus; Human papilloma virus infection; Human papillomavirus 16; Incidence; Individual; Intervention; Knowledge; Lead; Link; Location; Malignant Neoplasms; Malignant neoplasm of anus; Malignant neoplasm of cervix uteri; Maps; Measures; Mediating; Medical; Methods; Missouri; Modeling; Molecular; Molecular Epidemiology; Neighborhoods; Obesity; Oral cavity; Oropharyngeal; Outcome; Population; Positioning Attribute; Prevalence; Prevention; Primary Health Care; Primary Prevention; Reduce health disparities; Research; Research Personnel; Research Proposals; Risk; Risk Factors; Role; Rural; Sampling; Screening for cancer; Secondary Prevention; Smoking; Socioeconomic Status; Source; Stage at Diagnosis; Training; Treatment Failure; Tumor Bank; Tumor Markers; United States; Vaccination; Vulnerable Populations; Woman; Work; Youth; behavioral genomics; cancer health disparity; cancer risk; career; data registry; disparity reduction; experience; follow-up; health disparity; high risk; indexing; innovation; insight; knowledge base; malignant mouth neoplasm; malignant oropharynx neoplasm; medically underserved; molecular marker; mortality; optimal treatments; preventive intervention; prognostic significance; prognostication; programs; repository; rural area; screening; sexual debut; skills; social; social epidemiology; social factors; social genomics; social health determinants; social integration; socioeconomics; suburb; transportation access; tumor; underserved area

PROJECT SUMMARY/ABSTRACT Human Papillomavirus (HPV)-associated cancer has been dramatically rising for the last few decades. The development and implementation of HPV vaccination and screening provide the promise of prevention. Primary prevention and advances in genomic prognostication has shifted the landscape of HPV-associated cancers. Efficacious and equitable prevention and treatment efforts for vulnerable groups requires an understanding of geographic, social and molecular determinants of HPV-associated cancers unique to these underserved and understudied populations. The goal of this proposed research proposal is to study how social determinants of health influences and interacts with molecular tumor markers to affect HPV-associated cancers. Dr. Mazul’s career goal is to become an independent researcher who is uniquely positioned to develop, conduct, and communicate research bridging cancer social determinant of health biology with social epidemiology. In the proposed training plan, Dr. Mazul will build upon her cancer epidemiologic skills to develop additional expertise in geospatial analysis and social epidemiologic methods, while expanding her cancer knowledge into HPV- associated cancer biology. Her training will be directly applied to support and advance her career as an independent researcher and the proposed research plan. Geospatial and social epidemiologic methods will be employed to understanding the interaction between social and molecular factors. We will use data from three sources representing national, Missouri statewide and local St. Louis HPV-associated cancer cases to compare the three most common HPV-associated cancers (oropharyngeal, cervical and anal). Three aims will address the overall hypothesis that poor neighborhood-level factors interact with molecular markers and to lead to poor HPV-associated cancer outcomes. Aim 1. Identify nationwide and statewide spatial clusters of HPV-associated cancers using geographic information systems and geospatial modeling. Aim 2: Measure the effect of neighborhood-level social and demographic factors on HPV- associated cancer stage at presentation and survival. Aim 3: Measure the prevalence and prognostic significance of HPV genotype in a demographically and socioeconomically diverse HPV-associated cancer population. Results from this study will provide a more nuanced assessment of the complex social and genomic factors linked with HPV-associated cancer. With this training and experience, Dr. Mazul will be well positioned to launch her independent research career.

项目总结/文摘