Patient Oriented Research and Mentorship and Training in Functional Neuroimaging of Obsessive-Compulsive Disorder

摘要 这个K24中期职业调查员职业发展奖寻求培训和指导的支持， Christopher Pittenger，医学博士，哲学博士，他是耶鲁大学精神病学著名的终身副教授， 耶鲁大学强迫症研究诊所的主任，精神病学系转化研究的助理主席。博士 Pittenger领导了一个强大的以患者为导向的研究（POR）研究计划，该计划与他的研究计划相结合。 基于实验室的基础/转化研究，并对神经生物学基础产生了重要的新见解 以及强迫症（OCD）和抽动秽语综合征（TS）的新治疗途径。皮腾格医生有一个 长期致力于指导;最值得注意的是，他是神经科学研究培训的联合主任 计划（NRTP），耶鲁精神病学住院医师的研究轨道。 这项资助支持的培训计划将使Pittenger博士能够提高他在定量分析方面的技能， 专注于先进的统计方法和功能磁共振成像研究的设计和分析。这些领域他已经 与专家合作者进行积极的研究;拟议培训计划的目的是提高他自己的熟练程度， 使他在这些重要领域成为更有效的合作者和导师。额外的训练集中在他的 作为导师和领导者的能力，以提高他在管理自己的研究方面的效率为目标 团体和有效的个性化指导。这些培训活动将在两个国家卫生研究所- 资助的研究。第一个，R 01 MH 116038，是一个最近资助的赠款，Pittenger博士是共同PI与他的关闭 合作者Alan Anticevic，并部署了尖端的成像技术和数据分析方法来检查大脑 网络连接平行性和强迫症药物治疗反应的预测因子。第二个，R 01 MH 100068是与合作者Michelle Hampson合作的一项基金，该基金正在开发实时功能磁共振成像神经反馈作为探针 以及治疗强迫症的潜在方法，并取得了有希望的早期结果。这两个令人兴奋的项目提供了一个富有成效的工具， 统计学和神经成像方面的培训。 Pittenger博士将在该奖项下投入大量时间进行指导。一个主要的焦点将是NRTP;该计划 是让他在未来几年里接任这个项目的负责人，并在下一次重新提交时发挥带头作用。 2022年的T32补助金支持这种加强指导的努力是目前的第二个主要动机 应用程序. Pittenger博士还将在自己的研究中为学生，博士后和初级教师提供指导 整个精神病学系 总之，这些培训、研究和指导的综合计划将支持一个完善的中期职业生涯 他的强大研究项目正在对神经生物学和强迫症的治疗产生重要的见解 和TS，他们致力于指导工作，帮助建立新一代的 精神神经科学中以病人为导向的研究人员。

ABSTRACT This K24 Mid-Career Investigator Career Development Award seeks support for training and mentorship for Christopher Pittenger, MD, Ph.D., a well-established, tenured Associate Professor in Psychiatry at Yale University, Director of the Yale OCD Research Clinic, and Assistant Chair for Translational Research in the Department of Psychiatry. Dr. Pittenger leads a robust patient-oriented research (POR) research program, which is integrated with his basic/translational lab-based research and has produced important new insights into the neurobiological underpinnings and novel treatment avenues for obsessive-compulsive disorder (OCD) and Tourette syndrome (TS). Dr. Pittenger has a long-standing commitment to mentorship; most notably, he is Co-Director of the Neuroscience Research Training Program (NRTP), the research track within the Yale psychiatry residency. The training plan supported by this grant will allow Dr. Pittenger to increase his skills in quantitative analysis, with a focus on advanced statistical methods and on the design and analysis of fMRI studies. These are areas in which he already has active research with expert collaborators; the aim of the proposed training plan is to enhance his own proficiency to make him a more effective collaborator and mentor in these important domains. Additional training is focused on his own abilities as a mentor and leader, with the goal of increasing his efficacy in the management of his own research groups and in effective and individualized mentorship. These training activities will take place in the context of two NIMH- funded research studies. The first, R01 MH116038, is a recently funded grant on which Dr. Pittenger is co-PI with his close collaborator Alan Anticevic and deploys cutting-edge imaging technology and data analysis approaches to examine brain network connectivity parallels and predictors of therapeutic response to pharmacotherapy in OCD. The second, R01 MH100068, is a grant with collaborator Michelle Hampson that is developing real-time fMRI neurofeedback as a probe and potential treatment for OCD, with promising early results. These two exciting projects provide a fruitful vehicle for the proposed training in statistics and neuroimaging. Dr. Pittenger will devote substantial time to mentoring under this award. One major focus will be the NRTP; the plan is for him to take over as Director of this program over the next few years, and to take the lead in the next resubmission of our T32 grant in 2022. Support of this increased mentorship effort is a second major motivation for the current application. Dr. Pittenger will also provide mentorship to students, postdocs, and junior faculty in his own research program and throughout the Department of Psychiatry Together, these integrated plans for training, research, and mentorship will support a well-established mid-career investigator whose robust research program is producing important insights into the neurobiology and treatment of OCD and TS, and whose dedicated mentorship efforts are helping to establish a new generation of translationally grounded patient-oriented researchers in psychiatric neuroscience.