Patient Oriented Research and Mentorship and Training in Functional Neuroimaging of Obsessive-Compulsive Disorder

摘要 这项K24职业中期调查员职业发展奖旨在为以下方面的培训和指导提供支持 克里斯托弗·皮滕格，医学博士，耶鲁大学精神病学终身副教授，主任 耶鲁大学强迫症研究诊所教授，精神病学系翻译研究助理主任。Dr。 皮滕格领导着一个强大的以患者为导向的研究计划，该计划与HIS 基础/转化性实验室研究，并对神经生物学基础产生了重要的新见解 以及治疗强迫症(OCD)和抽动症(TS)的新途径。皮滕格医生有一个 长期致力于指导；最引人注目的是，他是神经科学研究培训中心的联席主任 计划(NRTP)，耶鲁精神病学住院医师的研究轨道。 这笔赠款支持的培训计划将使皮滕格博士能够提高他在定量分析方面的技能， 专注于先进的统计方法和功能磁共振研究的设计和分析。在这些领域，他已经 与专家合作者进行积极的研究；拟议的培训计划的目的是提高自己的熟练程度，以 让他在这些重要领域成为更有效的合作者和导师。额外的培训集中在他的 自己作为导师和领导者的能力，目标是提高他在管理自己的研究方面的效率 并在有效和个人化的指导下进行。这些培训活动将在两个NIMH的背景下进行- 资助研究研究。第一个是R01 MH116038，是最近资助的一笔赠款，皮滕格博士与他的近亲共同参与了这笔赠款 合作者Alan Anticevic和部署尖端成像技术和数据分析方法来检查大脑 网络连通性与强迫症药物治疗反应的相关性和预测性。第二个，R01 MH100068是与合作伙伴Michelle Hampson共同开发实时功能磁共振神经反馈作为探针的赠款 以及强迫症的潜在治疗方法，早期结果令人振奋。这两个令人兴奋的项目为 拟议的统计和神经成像方面的培训。 皮滕格博士将在这一奖项下投入大量时间进行指导。一个主要的焦点将是NRTP；该计划 是让他在接下来的几年里接任这个项目的主任，并在下一次重新提交时带头 在2022年我们的T32拨款中。对这种增加的指导努力的支持是目前 申请。皮滕格博士还将在他自己的研究中为学生、博士后和初级教师提供指导 计划和整个精神病学系 这些综合的培训、研究和指导计划将共同支持职业生涯中期的良好发展。 研究员，其强有力的研究计划正在对神经生物学和强迫症的治疗产生重要的见解 和TS，他们专注的指导努力正在帮助建立新一代以翻译为基础的 以病人为中心的精神神经科学研究人员。

ABSTRACT This K24 Mid-Career Investigator Career Development Award seeks support for training and mentorship for Christopher Pittenger, MD, Ph.D., a well-established, tenured Associate Professor in Psychiatry at Yale University, Director of the Yale OCD Research Clinic, and Assistant Chair for Translational Research in the Department of Psychiatry. Dr. Pittenger leads a robust patient-oriented research (POR) research program, which is integrated with his basic/translational lab-based research and has produced important new insights into the neurobiological underpinnings and novel treatment avenues for obsessive-compulsive disorder (OCD) and Tourette syndrome (TS). Dr. Pittenger has a long-standing commitment to mentorship; most notably, he is Co-Director of the Neuroscience Research Training Program (NRTP), the research track within the Yale psychiatry residency. The training plan supported by this grant will allow Dr. Pittenger to increase his skills in quantitative analysis, with a focus on advanced statistical methods and on the design and analysis of fMRI studies. These are areas in which he already has active research with expert collaborators; the aim of the proposed training plan is to enhance his own proficiency to make him a more effective collaborator and mentor in these important domains. Additional training is focused on his own abilities as a mentor and leader, with the goal of increasing his efficacy in the management of his own research groups and in effective and individualized mentorship. These training activities will take place in the context of two NIMH- funded research studies. The first, R01 MH116038, is a recently funded grant on which Dr. Pittenger is co-PI with his close collaborator Alan Anticevic and deploys cutting-edge imaging technology and data analysis approaches to examine brain network connectivity parallels and predictors of therapeutic response to pharmacotherapy in OCD. The second, R01 MH100068, is a grant with collaborator Michelle Hampson that is developing real-time fMRI neurofeedback as a probe and potential treatment for OCD, with promising early results. These two exciting projects provide a fruitful vehicle for the proposed training in statistics and neuroimaging. Dr. Pittenger will devote substantial time to mentoring under this award. One major focus will be the NRTP; the plan is for him to take over as Director of this program over the next few years, and to take the lead in the next resubmission of our T32 grant in 2022. Support of this increased mentorship effort is a second major motivation for the current application. Dr. Pittenger will also provide mentorship to students, postdocs, and junior faculty in his own research program and throughout the Department of Psychiatry Together, these integrated plans for training, research, and mentorship will support a well-established mid-career investigator whose robust research program is producing important insights into the neurobiology and treatment of OCD and TS, and whose dedicated mentorship efforts are helping to establish a new generation of translationally grounded patient-oriented researchers in psychiatric neuroscience.