Evidence accumulation in obsessive-compulsive disorder during perceptual and value-based decisions
在基于知觉和价值的决策过程中强迫症的证据积累
基本信息
- 批准号:9755518
- 负责人:
- 金额:$ 20.94万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-08-03 至 2020-12-31
- 项目状态:已结题
- 来源:
- 关键词:AffectAnteriorAttenuatedBasal GangliaBehaviorBehavior ControlBehavioralBiological MarkersBlueberriesBrainCategoriesCognitionCokeComplexCompulsive BehaviorComputer SimulationCorpus striatum structureCouplingDataDecision MakingDeep Brain StimulationDevelopmentDiagnosisDiagnosticDiffusionDimensionsDiseaseDistressEquus caballusFrequenciesFunctional Magnetic Resonance ImagingFunctional disorderFutureGoalsHeterogeneityIce CreamImpulsivityIndividualLeadLinkMapsMeasuresMedialModelingNeurobiologyNeurocognitiveObsessionObsessive-Compulsive DisorderOrangesParietalPersonsPharmacological TreatmentPopulationPrefrontal CortexProceduresProcessPublishingRefractoryResearchRestRoleSensoryServicesSpecific qualifier valueStructure of subthalamic nucleusSymptomsTeaTestingTimeTranscranial magnetic stimulationUncertaintyWorkbasebehavioral impairmentbiomarker developmentcingulate cortexclinical developmentcompulsiondisorder controldriving behaviorendophenotypeflexibilityfootindividual variationinterestneural networkneurofeedbacknovelnovel therapeutic interventionnovel therapeuticspotential biomarkerrecruitrelating to nervous systemresponsesymptomatologytheoriestreatment response
项目摘要
7. Project Summary
Decision making in the real world is complex and is modulated by numerous factors. We and others have found
that specific aspects of decision making are abnormal in individuals with obsessive-compulsive disorder (OCD).
We hypothesize that these abnormalities are related to both dysfunctions in neural cortico-basal ganglia circuits
and the development of clinical symptomatology in such domains as indecisiveness, behavioral inflexibility, and
compulsive repetition of actions. OCD affects about 1 person in 40; obsessions and compulsions are found in
many more. Elucidating their relationship to underlying neurocognitive abnormalities is of fundamental
importance and may ultimately lead to diagnostic clarification and new therapeutic interventions.
This proposal seeks to employ the computational drift diffusion model (DDM) framework to refine and quantify
the cortico-basal ganglia theory of OCD, which is widely accepted but remains qualitative. We employ the “hold-
your-horses” model of subthalamic nucleus (STN) function to characterize individual variation in responses to
changes in task difficulty and task context, on both behavioral and neurobiological levels, and their relations to
OCD symptomatology. The model suggests that STN activity and connectivity contribute to individual ability to
adjust the process of decision formation to meet current task demands, by modulating how much evidence needs
to be accumulated before a choice between alternatives is made. This contributes to behavioral flexibility; we
expect this STN function to be abnormal in OCD. Consistent with this hypothesis, prior studies and our pilot data
suggest that individuals with OCD require more evidence before they make a perceptual categorization decision,
which may lead to indecisiveness; but they tend to accumulate less evidence before making an value-based
decision (when asked to choose which of two options is preferred), which may lead to reduced response inhibition
and poor quality decisions (such as we have previously documented). Differences in decision making across
these two contexts have rarely been systematically investigated (and never in OCD). Our novel task allows direct
comparison of perceptual and value-based decisions, while varying tasks difficulty, using the rigorous DDM-
based analysis on both behavioral and neural levels. Our pilot data demonstrate the feasibility of our approach.
This proposal combines a novel theoretical framework of neurocognitive abnormalities in OCD, a sophisticated
computational approach, and a specific mechanistic hypothesis implicating the STN and associated networks in
OCD pathophysiology. These will be tested using hierarchical Bayesian estimation of DDM parameters in
conjunction with state-of-the-art fMRI analyses. Quantifying STN abnormalities with DDM will help us to
disentangle OCD-related abnormalities in basic neurocognitive processes and to begin to place the cortico-basal
ganglia model of OCD on a more quantitative footing. In future work these analyses can be applied
transdiagnostically. Ultimately, we hope this work will produce biomarkers of pharmacological treatment
response, and may contribute to novel therapeutics modulating the implicated circuitries.
7.项目摘要
真实的世界中的决策是复杂的,并受到许多因素的影响。我们和其他人发现
强迫症(OCD)患者决策的特定方面是异常的。
我们推测这些异常与神经皮质-基底节回路的功能障碍有关
以及临床诊断学在诸如优柔寡断、行为不确定性等领域的发展,
强迫性重复动作。强迫症影响约40人中的1人;强迫症和强迫症被发现,
更多.阐明它们与潜在的神经认知异常的关系是至关重要的
重要性,并可能最终导致诊断澄清和新的治疗干预措施。
该建议旨在采用计算漂移扩散模型(DDM)框架来细化和量化
强迫症的皮质基底神经节理论,这是广泛接受的,但仍然定性。我们使用“保持-
你的马”模型的丘脑底核(ESTA)的功能,以表征个体差异的反应,
在行为和神经生物学水平上,任务难度和任务背景的变化,以及它们与
强迫症治疗学该模型表明,活动和连接有助于个人的能力,
调整决策形成的过程,以满足当前的任务需求,通过调整证据的需求量
在做出选择之前积累起来。这有助于行为的灵活性;我们
预期这一功能在强迫症中是异常的。与这一假设相一致,先前的研究和我们的试点数据
表明强迫症患者在做出知觉分类决定之前需要更多证据,
这可能会导致犹豫不决;但他们倾向于在做出基于价值的判断之前积累较少的证据,
决策(当被要求选择两个选项中的哪一个是首选),这可能导致反应抑制减少
和低质量的决策(如我们以前记录的)。决策过程中的差异
这两种背景很少被系统地研究(在强迫症中也从未)。我们的新任务允许直接
比较知觉和价值为基础的决定,而不同的任务难度,使用严格的DDM-
基于行为和神经层面的分析。我们的试点数据证明了我们的方法的可行性。
这一建议结合了强迫症神经认知异常的一个新的理论框架,
计算方法,以及一个具体的机械假设,涉及的神经网络和相关的网络,
强迫症病理生理学。这些将使用DDM参数的分层贝叶斯估计进行检验,
结合最先进的功能磁共振成像分析用DDM量化脑血管异常将有助于我们
在基本的神经认知过程中解开强迫症相关的异常,并开始将皮质基底神经元
强迫症的神经节模型进行定量分析在今后的工作中,这些分析可以应用于
transdiagnosis诊断。最终,我们希望这项工作将产生药物治疗的生物标志物
反应,并可能有助于新的治疗调制牵连电路。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Christopher John Pittenger其他文献
Christopher John Pittenger的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Christopher John Pittenger', 18)}}的其他基金
Examining individual differences in large scale brain networks in individuals with OCD and their relations to heterogeneity of obsessive compulsive symptoms.
检查强迫症患者大规模大脑网络的个体差异及其与强迫症状异质性的关系。
- 批准号:
10624934 - 财政年份:2022
- 资助金额:
$ 20.94万 - 项目类别:
Anti-interneuron antibodies in rapid-onset pediatric OCD: clinical generalization and target identification
快速发作的儿科强迫症中的抗中间神经元抗体:临床概括和靶标识别
- 批准号:
10530955 - 财政年份:2022
- 资助金额:
$ 20.94万 - 项目类别:
Dysregulation of dopamine receptors in the basal ganglia in OCD and tic disorders: Positron Emission Tomography with [11C]-PHNO
强迫症和抽动障碍中基底神经节多巴胺受体的失调:[11C]-PHNO 正电子发射断层扫描
- 批准号:
10672999 - 财政年份:2022
- 资助金额:
$ 20.94万 - 项目类别:
Examining individual differences in large scale brain networks in individuals with OCD and their relations to heterogeneity of obsessive compulsive symptoms.
检查强迫症患者大规模大脑网络的个体差异及其与强迫症状异质性的关系。
- 批准号:
10527692 - 财政年份:2022
- 资助金额:
$ 20.94万 - 项目类别:
Dysregulation of dopamine receptors in the basal ganglia in OCD and tic disorders: Positron Emission Tomography with [11C]-PHNO
强迫症和抽动障碍中基底神经节多巴胺受体的失调:[11C]-PHNO 正电子发射断层扫描
- 批准号:
10501537 - 财政年份:2022
- 资助金额:
$ 20.94万 - 项目类别:
Patient Oriented Research and Mentorship and Training in Functional Neuroimaging of Obsessive-Compulsive Disorder
强迫症功能神经影像以患者为导向的研究、指导和培训
- 批准号:
10314023 - 财政年份:2020
- 资助金额:
$ 20.94万 - 项目类别:
Patient Oriented Research and Mentorship and Training in Functional Neuroimaging of Obsessive-Compulsive Disorder
强迫症功能神经影像以患者为导向的研究、指导和培训
- 批准号:
10535440 - 财政年份:2020
- 资助金额:
$ 20.94万 - 项目类别:
Anti-interneuron antibodies in abrupt-onset pediatric obsessive-compulsive disorder
突发性小儿强迫症中的抗中间神经元抗体
- 批准号:
9916831 - 财政年份:2019
- 资助金额:
$ 20.94万 - 项目类别:
Histamine Regulation of the Basal Ganglia and the Pathophysiology of Tics
基底神经节的组胺调节和抽动的病理生理学
- 批准号:
9288634 - 财政年份:2017
- 资助金额:
$ 20.94万 - 项目类别:
Histamine Regulation of the Basal Ganglia and the Pathophysiology of Tics
基底神经节的组胺调节和抽动的病理生理学
- 批准号:
10093144 - 财政年份:2017
- 资助金额:
$ 20.94万 - 项目类别:
相似海外基金
Impact of tissue resident memory T cells on the neuro-immune pathophysiology of anterior eye disease
组织驻留记忆 T 细胞对前眼疾病神经免疫病理生理学的影响
- 批准号:
10556857 - 财政年份:2023
- 资助金额:
$ 20.94万 - 项目类别:
Fear and anxiety circuit mechanisms in anterior hypothalamic nucleus
下丘脑前核的恐惧和焦虑环路机制
- 批准号:
10789153 - 财政年份:2023
- 资助金额:
$ 20.94万 - 项目类别:
Elucidating signaling networks in Anterior Segment development, repair and diseases
阐明眼前节发育、修复和疾病中的信号网络
- 批准号:
10718122 - 财政年份:2023
- 资助金额:
$ 20.94万 - 项目类别:
The Intimate Interplay Between Keratoconus, Sex Hormones, and the Anterior Pituitary
圆锥角膜、性激素和垂体前叶之间的密切相互作用
- 批准号:
10746247 - 财政年份:2023
- 资助金额:
$ 20.94万 - 项目类别:
Anterior Insula Projections for Alcohol Drinking/Anxiety Interactions in Female and Male Rats
雌性和雄性大鼠饮酒/焦虑相互作用的前岛叶预测
- 批准号:
10608759 - 财政年份:2023
- 资助金额:
$ 20.94万 - 项目类别:
Impact of tissue resident memory T cells on the neuro-immunepathophysiology of anterior eye disease
组织驻留记忆 T 细胞对前眼疾病神经免疫病理生理学的影响
- 批准号:
10804810 - 财政年份:2023
- 资助金额:
$ 20.94万 - 项目类别:
Investigation of the effect of anterior eye shape on myopia progression due to prolonged near work.
研究因长时间近距离工作而导致的前眼形状对近视进展的影响。
- 批准号:
23K09063 - 财政年份:2023
- 资助金额:
$ 20.94万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Generation and characterization of anterior pituitary stem cells from human pluripotent stem cells
人多能干细胞垂体前叶干细胞的产生和表征
- 批准号:
23K08005 - 财政年份:2023
- 资助金额:
$ 20.94万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Anterior cruciate ligament injury: towards a gendered environmental approach
前十字韧带损伤:走向性别环境方法
- 批准号:
485090 - 财政年份:2023
- 资助金额:
$ 20.94万 - 项目类别:
Operating Grants
EASI-TOC: Endovascular Acute Stroke Intervention-Tandem OCclusion: atrial of acute cervical internal carotid artery stenting during endovascularthrombectomy for anterior circulation stroke
EASI-TOC:血管内急性卒中干预-串联闭塞:前循环卒中血管内血栓切除术期间急性颈内动脉心房支架置入术
- 批准号:
490056 - 财政年份:2023
- 资助金额:
$ 20.94万 - 项目类别:
Operating Grants