Evaluating Exposure to Unconventional Oil and Gas Development and Childhood Leukemia Risk

评估非常规石油和天然气开发与儿童白血病风险

• 批准号: 10318517
• 负责人: Cassandra Jane Clark
• 金额: $ 2.34万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10318517
• 关键词: Accounting; Acute Lymphocytic Leukemia; Address; Age; Air; Air Pollution; Assessment tool; Attenuated; Birth; Carcinogens; Case-Control Studies; Chemicals; Child; Childhood Acute Lymphocytic Leukemia; Childhood Leukemia; Colorado; Complex; Confounding Factors (Epidemiology); Development; Diagnosis; Disease; Environmental Exposure; Environmental Health; Environmental Impact; Environmental Monitoring; Epidemiology; Exposure to; Frequencies; Future; Gases; Goals; Health; Health Policy; Incidence; Individual; Industry; Intervention; Liquid substance; Malignant Childhood Neoplasm; Measurement; Methods; Modeling; Nature; Non-Hematologic Malignancy; Ohio; Oils; Outcome; Parents; Pennsylvania; Phase; Policies; Population; Population Study; Populations at Risk; Public Health; Publishing; Registries; Research Personnel; Resources; Risk; Risk Factors; Running; Standardization; Stress; Suggestion; Water; Water Pollutants; Water Pollution; Woman; Work; adverse birth outcomes; base; cancer risk; cancer type; carcinogenicity; case control; chemical carcinogen; contaminant transport; contaminated drinking water; contaminated water; design; drinking water; epidemiologic data; epidemiology study; exposed human population; hazard; hydraulic fracturing; improved; leukemia; multidisciplinary; novel; population based; public health intervention; rapid growth; residence; risk sharing; skills; sociodemographics; stressor; water sampling; water testing

Project Summary Unconventional oil and gas development (UOGD), commonly referred to as hydraulic fracturing, has expanded rapidly over the past decade, leading to an estimated 4 million people living within one mile of a hydraulically fractured well. Despite the widespread nature of the industry, little is understood about the risks and exposures to individuals living near UOGD facilities. Due to the chemical- and water-intensive nature of UOGD, drinking water contamination by UOGD fluids and wastewater and the resulting potential for children living near UOGD to be exposed to chemical carcinogens are major public health concerns. Approximately 30 epidemiologic studies of UOG published to date, including two on childhood cancer, have relied on proximity-based spatial surrogates to ascertain exposure. While proximity-based metrics may serve as useful surrogates for collectively capturing numerous potential stressors of UOGD (e.g., air pollution, stress), their correlations with specific environmental measurements, such as concentrations of water contaminants, is unknown. In the proposed project, we will apply drinking water monitoring and epidemiological data to evaluate exposure to carcinogenic compounds related to UOG and improve our understanding of childhood cancer risk from UOGD. We will use measurements in drinking water samples we collected from >250 residences in Pennsylvania and Ohio to evaluate the relationship between commonly used spatial metrics as well as a newly developed water vulnerability model and drinking water concentrations of carcinogens. We will also examine whether the spatial surrogates are more strongly correlated with drinking water contaminant concentrations with the addition of other covariates, such as UOG well age, depth, and phase of development. Using these traditional and newly developed exposure metrics, we will then conduct a population-based case- control study investigating the association between UOGD exposure and risk of childhood leukemia in Pennsylvania and Ohio. My overarching hypothesis is that UOGD releases carcinogenic chemicals that may increase risk of childhood cancer. We expect that this work will provide important information on the potential health effects of exposure to carcinogenic compounds related to UOGD, as well as evaluate several available methods to assess this exposure. Such information can be used to guide public health policy and inform public health interventions, environmental monitoring, and future studies on UOGD exposure. This work will also support my development as an independent researcher conducting policy-relevant environmental health and exposure studies, with a focus on impacts to women and children.

项目摘要 非常规石油和天然气开发(UOGD)，通常被称为水力压裂，已经扩大 在过去的十年里，导致估计有400万人生活在一英里内的液压 骨折很严重。尽管该行业具有广泛的性质，但人们对其中的风险和暴露知之甚少 居住在UOGD设施附近的个人。由于UOGD的化学和水密集性，饮用 UOGD液体和废水对水的污染及其对居住在UOGD附近的儿童的潜在影响 接触化学致癌物是主要的公共卫生问题。大约30名流行病学 到目前为止发表的关于UOG的研究，包括两项关于儿童癌症的研究，一直依赖于基于邻近的空间 代孕者以确定接触情况。虽然基于邻近度的度量可以作为以下方面的有用替代品 集中捕捉UOGD的众多潜在应激源(例如，空气污染、压力)，它们与 具体的环境测量，如水污染物的浓度，是未知的。在 拟议的项目，我们将应用饮用水监测和流行病学数据来评估 接触与UOG相关的致癌化合物，提高我们对童年的理解 来自UOGD的癌症风险。我们将在我们从&gt；250收集的饮用水样本中使用测量方法 宾夕法尼亚州和俄亥俄州的住宅评估常用的空间度量之间的关系，如 以及新开发的水脆弱性模型和饮用水致癌物质浓度。我们会 也要检查空间代用品是否与饮用水污染物有更强的相关性 浓度与其他协变量的添加，例如UOG井龄、深度和开发阶段。 使用这些传统的和新开发的暴露指标，我们将进行基于人群的案例- 年UOGD暴露与儿童白血病风险关系的对照研究 宾夕法尼亚州和俄亥俄州。我的主要假设是，UOGD释放的致癌化学物质可能 增加儿童患癌症的风险。我们期待这项工作将提供有关潜在的重要信息 暴露于与UOGD相关的致癌化合物对健康的影响，以及评估几种可用的 评估这种暴露的方法。这些信息可以用来指导公共卫生政策和向公众提供信息 健康干预、环境监测和关于UOGD暴露的未来研究。这项工作还将 支持我作为独立研究员的发展，从事与政策相关的环境健康和 暴露研究，重点是对妇女和儿童的影响。

项目成果

Assessing Exposure to Unconventional Oil and Gas Development: Strengths, Challenges, and Implications for Epidemiologic Research.

• DOI: 10.1007/s40572-022-00358-4
• 发表时间: 2022-09
• 期刊: CURRENT ENVIRONMENTAL HEALTH REPORTS
• 影响因子: 7.9
• 作者: Deziel, Nicole C.;Clark, Cassandra J.;Casey, Joan A.;Bell, Michelle L.;Plata, Desiree L.;Saiers, James E.
• 通讯作者: Saiers, James E.