Evaluating Exposure to Unconventional Oil and Gas Development and Childhood Leukemia Risk
评估非常规石油和天然气开发与儿童白血病风险
基本信息
- 批准号:10318517
- 负责人:
- 金额:$ 2.34万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-01 至 2022-05-31
- 项目状态:已结题
- 来源:
- 关键词:AccountingAcute Lymphocytic LeukemiaAddressAgeAirAir PollutionAssessment toolAttenuatedBirthCarcinogensCase-Control StudiesChemicalsChildChildhood Acute Lymphocytic LeukemiaChildhood LeukemiaColoradoComplexConfounding Factors (Epidemiology)DevelopmentDiagnosisDiseaseEnvironmental ExposureEnvironmental HealthEnvironmental ImpactEnvironmental MonitoringEpidemiologyExposure toFrequenciesFutureGasesGoalsHealthHealth PolicyIncidenceIndividualIndustryInterventionLiquid substanceMalignant Childhood NeoplasmMeasurementMethodsModelingNatureNon-Hematologic MalignancyOhioOilsOutcomeParentsPennsylvaniaPhasePoliciesPopulationPopulation StudyPopulations at RiskPublic HealthPublishingRegistriesResearch PersonnelResourcesRiskRisk FactorsRunningStandardizationStressSuggestionWaterWater PollutantsWater PollutionWomanWorkadverse birth outcomesbasecancer riskcancer typecarcinogenicitycase controlchemical carcinogencontaminant transportcontaminated drinking watercontaminated waterdesigndrinking waterepidemiologic dataepidemiology studyexposed human populationhazardhydraulic fracturingimprovedleukemiamultidisciplinarynovelpopulation basedpublic health interventionrapid growthresidencerisk sharingskillssociodemographicsstressorwater samplingwater testing
项目摘要
Project Summary
Unconventional oil and gas development (UOGD), commonly referred to as hydraulic fracturing, has expanded
rapidly over the past decade, leading to an estimated 4 million people living within one mile of a hydraulically
fractured well. Despite the widespread nature of the industry, little is understood about the risks and exposures
to individuals living near UOGD facilities. Due to the chemical- and water-intensive nature of UOGD, drinking
water contamination by UOGD fluids and wastewater and the resulting potential for children living near UOGD
to be exposed to chemical carcinogens are major public health concerns. Approximately 30 epidemiologic
studies of UOG published to date, including two on childhood cancer, have relied on proximity-based spatial
surrogates to ascertain exposure. While proximity-based metrics may serve as useful surrogates for
collectively capturing numerous potential stressors of UOGD (e.g., air pollution, stress), their correlations with
specific environmental measurements, such as concentrations of water contaminants, is unknown. In the
proposed project, we will apply drinking water monitoring and epidemiological data to evaluate
exposure to carcinogenic compounds related to UOG and improve our understanding of childhood
cancer risk from UOGD. We will use measurements in drinking water samples we collected from >250
residences in Pennsylvania and Ohio to evaluate the relationship between commonly used spatial metrics as
well as a newly developed water vulnerability model and drinking water concentrations of carcinogens. We will
also examine whether the spatial surrogates are more strongly correlated with drinking water contaminant
concentrations with the addition of other covariates, such as UOG well age, depth, and phase of development.
Using these traditional and newly developed exposure metrics, we will then conduct a population-based case-
control study investigating the association between UOGD exposure and risk of childhood leukemia in
Pennsylvania and Ohio. My overarching hypothesis is that UOGD releases carcinogenic chemicals that may
increase risk of childhood cancer. We expect that this work will provide important information on the potential
health effects of exposure to carcinogenic compounds related to UOGD, as well as evaluate several available
methods to assess this exposure. Such information can be used to guide public health policy and inform public
health interventions, environmental monitoring, and future studies on UOGD exposure. This work will also
support my development as an independent researcher conducting policy-relevant environmental health and
exposure studies, with a focus on impacts to women and children.
项目总结
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Assessing Exposure to Unconventional Oil and Gas Development: Strengths, Challenges, and Implications for Epidemiologic Research.
- DOI:10.1007/s40572-022-00358-4
- 发表时间:2022-09
- 期刊:
- 影响因子:7.9
- 作者:Deziel, Nicole C.;Clark, Cassandra J.;Casey, Joan A.;Bell, Michelle L.;Plata, Desiree L.;Saiers, James E.
- 通讯作者:Saiers, James E.
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Cassandra Jane Clark其他文献
Cassandra Jane Clark的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Cassandra Jane Clark', 18)}}的其他基金
Evaluating Exposure to Unconventional Oil and Gas Development and Childhood Leukemia Risk
评估非常规石油和天然气开发与儿童白血病风险
- 批准号:
10066817 - 财政年份:2020
- 资助金额:
$ 2.34万 - 项目类别:
相似海外基金
Understanding of the onset and recurrence pattern of intractable acute lymphocytic leukemia based on clone analysis
基于克隆分析了解难治性急性淋巴细胞白血病的发病和复发模式
- 批准号:
20K08723 - 财政年份:2020
- 资助金额:
$ 2.34万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Novel Inhibitors of Multi-Drug-Resistant Mutants of BCR-ABL for the Treatment of Chronic Myelogenous Leukemia (CML) and Ph Positive Acute Lymphocytic Leukemia (ALL).
BCR-ABL 多重耐药突变体的新型抑制剂,用于治疗慢性粒细胞白血病 (CML) 和 Ph 阳性急性淋巴细胞白血病 (ALL)。
- 批准号:
9047400 - 财政年份:2015
- 资助金额:
$ 2.34万 - 项目类别:
The Role of Genetic Variants in Sensitivity to Methotrexate in Acute Lymphocytic Leukemia Survivors
遗传变异在急性淋巴细胞白血病幸存者对甲氨蝶呤敏感性中的作用
- 批准号:
319114 - 财政年份:2014
- 资助金额:
$ 2.34万 - 项目类别:
Fellowship Programs
Targeting the Bone Marrow Microenvironment In Acute Lymphocytic Leukemia
针对急性淋巴细胞白血病的骨髓微环境
- 批准号:
8595788 - 财政年份:2013
- 资助金额:
$ 2.34万 - 项目类别:
Targeting hypoxic microenvironment in Acute Lymphocytic Leukemia
针对急性淋巴细胞白血病的缺氧微环境
- 批准号:
8023518 - 财政年份:2011
- 资助金额:
$ 2.34万 - 项目类别:
Targeting hypoxic microenvironment in Acute Lymphocytic Leukemia
针对急性淋巴细胞白血病的缺氧微环境
- 批准号:
8404025 - 财政年份:2011
- 资助金额:
$ 2.34万 - 项目类别:
Targeting hypoxic microenvironment in Acute Lymphocytic Leukemia
针对急性淋巴细胞白血病的缺氧微环境
- 批准号:
8220724 - 财政年份:2011
- 资助金额:
$ 2.34万 - 项目类别:
Targeting hypoxic microenvironment in Acute Lymphocytic Leukemia
针对急性淋巴细胞白血病的缺氧微环境
- 批准号:
8599754 - 财政年份:2011
- 资助金额:
$ 2.34万 - 项目类别:
INSULIN RESISTANCE IN CHILDREN WITH ACUTE LYMPHOCYTIC LEUKEMIA UNDERGOING INDUCT
正在接受治疗的急性淋巴细胞白血病儿童的胰岛素抵抗
- 批准号:
8356701 - 财政年份:2010
- 资助金额:
$ 2.34万 - 项目类别:
INSULIN RESISTANCE IN CHILDREN WITH ACUTE LYMPHOCYTIC LEUKEMIA UNDERGOING INDUCT
正在接受治疗的急性淋巴细胞白血病儿童的胰岛素抵抗
- 批准号:
8166720 - 财政年份:2009
- 资助金额:
$ 2.34万 - 项目类别: