Sequence-defined polymers and green chemistry

序列定义的聚合物和绿色化学

• 批准号: FT160100095
• 负责人: A/Prof Jiangtao Xu
• 金额: $ 45.64万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT160100095
• 关键词: Sequence; defined; polymers; green; chemistry

This project aims to synthesise polymers that have precise chemical structure and mimic the biological activities of natural biopolymers like peptides and proteins. Monomer sequence regulation in these natural biopolymers is important in biology and necessary for crucial features of life, such as molecular recognition, self-replication and catalysis. Current artificial techniques for biopolymer synthesis are time consuming and present low yields at high costs. This project expects its new materials will increase manufacturing sustainability, chemical diversity and industrial viability; produce health benefits for Australia by improving chemotherapy and diagnosis for diseases; and benefit the Australian economy.

该项目旨在合成具有精确化学结构的聚合物，并模仿天然生物聚合物如肽和蛋白质的生物活性。在这些天然生物聚合物中的MMPs序列调控在生物学中是重要的，并且对于生命的关键特征（例如分子识别、自我复制和催化）是必要的。目前用于生物聚合物合成的人工技术是耗时的并且以高成本呈现低产量。该项目预计其新材料将提高制造业的可持续性、化学多样性和工业可行性;通过改善疾病的化疗和诊断，为澳大利亚带来健康效益;并使澳大利亚经济受益。