Brain-based Mechanisms of Emotion Regulation in Aging and Mood Disorders

衰老和情绪障碍中基于大脑的情绪调节机制

• 批准号: 10319173
• 负责人: Katherine Elizabeth Burdick
• 金额: $ 82.12万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-12-15 至 2025-10-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10319173
• 关键词: Address; Adult; Affect; Affective; Age; Aging; Amygdaloid structure; Attention; Attenuated; Base of the Brain; Behavior; Biological; Biological Assay; Bipolar Disorder; Brain; Clinical; Cognition; Cognitive; Cognitive deficits; Complex; Coping Skills; Depressive disorder; Development; Diagnostic; Disease remission; Elderly; Emotional; Emotions; Enrollment; Goals; Impairment; Intervention; Learning; Longevity; Maintenance; Major Depressive Disorder; Maps; Measures; Mediating; Memory; Mental Depression; Mental disorders; Mood Disorders; Moods; National Institute of Mental Health; Negative Valence; Onset of illness; Outcome; Patient Self-Report; Patients; Pattern; Performance; Personal Satisfaction; Play; Process; Recurrence; Relapse; Reporting; Research Domain Criteria; Rest; Risk; Role; Sampling; Services; Social Functioning; Stimulus; Strategic Planning; Structure; Thinking; Well in self; Work; age related; aging brain; attentional bias; base; clinically relevant; cognitive control; critical period; emotion regulation; emotional experience; executive function; flexibility; functional disability; heuristics; improved; middle age; negative affect; network dysfunction; novel; sex; social; social deficits; therapy design; therapy resistant; trait; white matter change

PROJECT SUMMARY Effective emotion regulation (ER) requires the ability to flexibly and dynamically respond to affectively-valenced stimuli in the service of goal-directed behaviors. Patients with major mood disorders, including bipolar disorder (BD) and major depressive disorder (MDD) are characterized by brain-based abnormalities in affective processing and cognitive deficits that make it difficult for them to regulate their emotions. Disruptions in ER are thought to play a role in risk for onset of illness, a relapsing course, and incomplete remission. Aging may amplify poor outcomes in older adults with depression, as reflected in a more severe course and treatment resistance. In contrast, in healthy adults, ER improves across the lifespan with a shift from attending to negative to attending to positive stimuli in attention, learning and memory. Consistent with RDoC, we will leverage multiple units of analysis (circuit, performance, self-report) in a transdiagnostic sample enriched for a range of ER-related network functions, implicit attentional biases, and ER strategies. We will enroll 200 adults (ages 41-80) with an affectively-stable mood disorder (100 BD, 100 MDD), and 100 demographically-matched healthy controls, allowing us to capture the range from extreme positive to extreme negative emotional experience. We will assess performance-based affective biases, cognitive control, and resting-state functional connectivity (FC), to define age-related changes in ER circuitry. We will assay habitual use of ER strategies, social functioning, and well-being to determine how brain-based processes affect these functionally- and clinically-relevant outcomes. Impact. The goals of this project are directly aligned with the NIMH Strategic Plan to develop new ways of characterizing and treating mental illness that are predicated on understanding brain-based mechanisms. Beyond the heuristic value of understanding the specific mechanisms and developmental trajectory of ER in mid and late life, results can be used to inform the development of novel interventions (e.g., neurostimulation, cognitive interventions) designed to “rescue” the specific network dysfunctions that give rise to maladaptive ER in depressive disorders.

项目摘要 有效的情绪调节（ER）需要能够灵活和动态地对情感价值做出反应。 为目标导向行为服务的刺激。严重情绪障碍患者，包括双相情感障碍 (BD)和重度抑郁症（MDD）的特征是大脑中的情感异常， 处理和认知缺陷，使他们难以调节自己的情绪。急诊室的中断是 被认为在疾病发作、复发过程和不完全缓解的风险中起作用。衰老可能会放大 老年抑郁症患者预后差，表现为病程更严重和治疗抵抗。在 相反，在健康的成年人中，ER在整个生命周期中都会改善，从关注负面到关注负面， 注意力、学习和记忆的积极刺激。 与RDoC一致，我们将利用多个分析单元（电路、性能、自我报告）， 一个跨诊断样本，富含一系列ER相关网络功能，内隐注意力偏差和ER 战略布局我们将招募200名患有情感稳定型心境障碍（100 BD，100 MDD）的成人（年龄41-80）， 和100名人口统计学上匹配的健康对照，使我们能够捕捉到从极端阳性到 极端负面的情绪体验我们将评估基于表现的情感偏见，认知控制， 和静息状态功能连接（FC），以定义ER电路中与年龄相关的变化。我们将分析 习惯性使用ER策略，社会功能和幸福感，以确定基于大脑的过程如何影响 这些功能和临床相关的结果。 冲击该项目的目标与NIMH战略计划直接一致，以开发新的方法， 表征和治疗精神疾病是基于对大脑机制的理解。 除了了解中期ER的具体机制和发展轨迹的启发性价值之外 和晚年，结果可用于告知新干预措施的开发（例如，神经刺激， 认知干预），旨在“拯救”引起适应不良ER的特定网络功能障碍 在抑郁症中。