Comprehensive portrait of long-term cannabis users: Are they ready for old age?

此R01应用程序响应FOA PA-18-061：老年人使用大麻。宝贝- 年轻时开始吸食大麻并继续吸食大麻的婴儿潮一代 多年来，现在都进入了后来的生活。FOA优先考虑有关当前风险的新证据 终生吸食大麻的人与衰老过程和大脑老化有关的状况，包括 阿尔茨海默氏症及相关疾病的潜在风险。他们准备好了吗？ 成功衰老，晚年健康长寿？我们建议将中年储备期的特征 达尼丁研究中长期吸食大麻的状况，一项由1037名婴儿组成的队列 1972-73年在城市学习，2019年学习到45岁，保留率为94%。已经有8次浪潮 从13岁到45岁的深入临床大麻使用访谈，这是定义 作为这一FOA目标的用户。我们最感兴趣的群体是那些 在过去的30年里，他们每周到每天都吸食大麻，其中四分之三的人 大麻依赖标准。我们将测试这些长期吸食大麻的人是否这样做 表现出中年储备能力减弱，包括生物衰老加速。 加速衰老和储备减少对生活质量差、健康寿命短、 和早期死亡率。项目新颖的概念框架扩展了“保护性”的逻辑 对其他生活领域的认知储备能力：我们将在测试中研究储备 认知能力，但在神经结构和连接性方面也有储备，通过 神经成像，临床体检评估的身体健康储备，表观遗传学- 维持储备评估为全基因组DNA甲基化，以及财政储备 通过面谈、信用评级和税务记录进行评估。除了对以下方面的分析 连续的维度测量，分析将唯一能够比较长期 大麻吸毒者与5个信息量丰富的群体的对比：终身不吸食者，中年娱乐使用者， 以前依赖大麻的戒毒者，长期不吸食大麻的酒精滥用者，以及大麻- 免费长期吸烟者。就该项目的许多目标而言，达尼丁的研究 预期的重复措施允许比较长期用户与 在长期接触大麻之前，他们的年龄更小。创新之处在于：(1) 通过40年的前瞻性评估有效地定义了大麻使用历史，(2)我们的 未来老龄化储备的概念框架，(3)参与者的全面肖像 跨多个学科的老龄化相关指标的储备状况，收集在同一 个人。

This R01 application responds to FOA PA-18-061: Marijuana Use In Older Adults. Baby- boomers who began using cannabis as young people, and who have continued cannabis use for years, are now entering later life. The FOA prioritizes new evidence about the current risk status of life-long cannabis users in relation to the aging process, and the aging brain, including potential risk for Alzheimer’s disease and related disorders. How prepared are they for successful aging and a long healthspan in late life? We propose to characterize midlife reserve status of long-term cannabis users in the Dunedin Study, a cohort of 1037 infants born in one city in 1972-73 and studied to age 45 in 2019, with 94% retention. There have been 8 waves of in-depth clinical cannabis-use interviews from age 13 to age 45, a unique asset for defining the users who are the target of this FOA. Our primary group of interest are the cohort members who have used cannabis weekly-to-daily for the past 3 decades, three-quarters of whom have met cannabis-dependence criteria. We will test whether such long-term cannabis users do or do not show diminished reserve capacities in midlife, including accelerated biological aging. Accelerated aging and diminished reserve pose risk for poor quality of life, brief health span, and early mortality. The project’s novel conceptual framework extends the logic of “protective cognitive reserve capacities” to a range of other life domains: we will study reserve in tested cognitive abilities, but also reserve in neural structure and connectivity assessed through neuroimaging, physical-health reserve assessed in clinical medical examinations, epigenetic- maintenance reserve assessed as genome-wide DNA methylation, and financial reserves assessed through interviews, credit ratings and tax records. In addition to analyses of continuous dimensional measures, analyses will uniquely be able to compare long-term cannabis users against 5 informative groups: lifelong non-users, midlife recreational users, formerly cannabis-dependent quitters, cannabis-free long-term alcohol-abusers, and cannabis- free long-term tobacco-smokers. For many of the project’s Aims, the Dunedin Study’s prospective repeated measures allow the rare advantage of comparing long-term users against themselves at a younger age, before prolonged cannabis exposure. Innovations are: (1) cannabis-use histories validly defined with 4 decades of prospective assessments, (2) our conceptual framework of “reserve” for future aging, (3) a comprehensive portrait of participants’ reserve status on aging-relevant measures across multiple disciplines, collected in the same individuals.