Comprehensive portrait of long-term cannabis users: Are they ready for old age?

长期大麻使用者的全面画像：他们准备好迎接老年了吗？

• 批准号: 10088914
• 负责人: TERRIE E MOFFITT
• 金额: $ 32.29万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-12-15 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10088914
• 关键词: 3-Dimensional; Adolescent; Adult; Age; Aging; Algorithms; Alzheimer' s Disease; Alzheimer' s disease risk; Anxiety; Area; Attention deficit hyperactivity disorder; Biological Aging; Biological Markers; Blood; Brain; Cannabis; Cardiovascular system; Childhood; Cities; Clinical; Cognitive; Computerized Medical Record; DNA Methylation; Data; Data Analyses; Data Set; Development; Dimensions; Discipline; Disease; Drug Prescriptions; Elderly; Epigenetic Process; Future; Government; Headache; Health; Hepatic; Individual; Individual Differences; Infant; Injury; Interest Group; Interview; Kidney; Life; Logic; Lung; Magnetic Resonance Imaging; Maintenance; Marijuana Dependence; Measures; Mediation; Mental Depression; Mental Health; Metabolic; Methods; Methylation; Modeling; Motor; Musculoskeletal Pain; National Institute of Drug Abuse; Neuropsychology; Pain; Participant; Pattern; Personal Satisfaction; Portraits; Positioning Attribute; Prevention; Process; Prospective Studies; Publications; Publishing; Quality of life; Recording of previous events; Records; Research; Risk; Sampling; Savings; Secure; Services; Sleep; Structure; Surface; Taxes; Testing; Thick; Work; age related; aging brain; alcohol abuser; baby boomer; base; body system; brain abnormalities; cognitive ability; cognitive reserve; cognitive testing; cohort; convict; cost; disorder risk; experience; financial literacy; genome-wide; gray matter; health literacy; healthspan; human old age (65+); immune function; innovation; insurance claims; interest; marijuana use; marijuana user; medical examination; member; middle age; mortality; neuroimaging; novel; physical conditioning; physical inactivity; prospective; relating to nervous system; sleep quality; socioeconomics; tobacco smokers; welfare; white matter; whole genome

This R01 application responds to FOA PA-18-061: Marijuana Use In Older Adults. Baby- boomers who began using cannabis as young people, and who have continued cannabis use for years, are now entering later life. The FOA prioritizes new evidence about the current risk status of life-long cannabis users in relation to the aging process, and the aging brain, including potential risk for Alzheimer’s disease and related disorders. How prepared are they for successful aging and a long healthspan in late life? We propose to characterize midlife reserve status of long-term cannabis users in the Dunedin Study, a cohort of 1037 infants born in one city in 1972-73 and studied to age 45 in 2019, with 94% retention. There have been 8 waves of in-depth clinical cannabis-use interviews from age 13 to age 45, a unique asset for defining the users who are the target of this FOA. Our primary group of interest are the cohort members who have used cannabis weekly-to-daily for the past 3 decades, three-quarters of whom have met cannabis-dependence criteria. We will test whether such long-term cannabis users do or do not show diminished reserve capacities in midlife, including accelerated biological aging. Accelerated aging and diminished reserve pose risk for poor quality of life, brief health span, and early mortality. The project’s novel conceptual framework extends the logic of “protective cognitive reserve capacities” to a range of other life domains: we will study reserve in tested cognitive abilities, but also reserve in neural structure and connectivity assessed through neuroimaging, physical-health reserve assessed in clinical medical examinations, epigenetic- maintenance reserve assessed as genome-wide DNA methylation, and financial reserves assessed through interviews, credit ratings and tax records. In addition to analyses of continuous dimensional measures, analyses will uniquely be able to compare long-term cannabis users against 5 informative groups: lifelong non-users, midlife recreational users, formerly cannabis-dependent quitters, cannabis-free long-term alcohol-abusers, and cannabis- free long-term tobacco-smokers. For many of the project’s Aims, the Dunedin Study’s prospective repeated measures allow the rare advantage of comparing long-term users against themselves at a younger age, before prolonged cannabis exposure. Innovations are: (1) cannabis-use histories validly defined with 4 decades of prospective assessments, (2) our conceptual framework of “reserve” for future aging, (3) a comprehensive portrait of participants’ reserve status on aging-relevant measures across multiple disciplines, collected in the same individuals.

此 R01 应用程序响应 FOA PA-18-061：老年人吸食大麻。婴儿- 年轻时开始使用大麻并持续使用大麻的婴儿潮一代 多年来，现在已进入晚年。 FOA 优先考虑有关当前风险的新证据 终生大麻使用者与衰老过程和大脑衰老的关系，包括 阿尔茨海默病和相关疾病的潜在风险。他们准备得如何 成功老龄化和晚年健康寿命长？我们建议描述中年储备的特征 但尼丁研究中长期大麻使用者的状况，该研究包括 1037 名婴儿出生的队列 1972-73 年在城市学习，2019 年学习至 45 岁，保留率达 94%。已经有8波了 对 13 岁至 45 岁的大麻使用情况进行深入的临床访谈，这是定义大麻使用情况的独特资产 作为此 FOA 目标的用户。我们主要感兴趣的群体是那些 过去 30 年来每周都吸食大麻，其中四分之三的人曾吸食过大麻 大麻依赖标准。我们将测试这些长期吸食大麻的人是否这样做 显示中年储备能力下降，包括加速的生物衰老。 加速衰老和储备减少会带来生活质量差、健康寿命短、 和早期死亡。该项目新颖的概念框架扩展了“保护性”的逻辑 认知储备能力”扩展到一系列其他生活领域：我们将研究经过测试的储备能力 认知能力，而且还通过评估神经结构和连接性的储备 神经影像学、临床医学检查中评估的身体健康储备、表观遗传学 维持储备评估为全基因组 DNA 甲基化和财务储备 通过面谈、信用评级和税务记录进行评估。除了分析 连续的尺寸测量，分析将独特地能够比较长期 大麻使用者针对 5 个信息丰富的群体：终身不使用者、中年娱乐使用者、 以前依赖大麻的戒烟者、无大麻的长期酗酒者和大麻- 释放长期吸烟者。对于该项目的许多目标，但尼丁研究的 前瞻性重复测量具有将长期用户与长期用户进行比较的罕见优势 他们自己在年轻时，在长期接触大麻之前。创新之处在于：（1） 通过 4 个十年的前瞻性评估有效定义了大麻使用历史，(2) 我们的 未来老龄化“储备”的概念框架，（3）参与者的全面画像 跨多个学科的老龄化相关措施的储备状态，收集在同一 个人。