Epigenetic regulations of DNA and histone methylation and deMethylation: Structures and Mechanisms
DNA 和组蛋白甲基化和去甲基化的表观遗传调控:结构和机制
基本信息
- 批准号:10318519
- 负责人:
- 金额:$ 58.48万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-01-01 至 2024-12-31
- 项目状态:已结题
- 来源:
- 关键词:BiochemicalBrainCell Differentiation processCytosineDNADNA MethylationDNA Methylation RegulationDNA Modification MethylasesDNA Modification ProcessDevelopmentDioxygenasesEnzymesEpigenetic ProcessEventFetusGene ExpressionGenerationsGenomeGenomicsGerm LinesLeadLightMaintenanceMammalian CellMammalsModificationMolecularPositioning AttributeProteinsReactionRoleSeriesStructureT cell differentiationdemethylationepigenetic memoryepigenetic regulationhistone methylationoxidationprogramstranscription factoryoung adult
项目摘要
Summary/Abstract
The control of gene expression in mammals relies in part on modifications to cytosine residues in DNA, which
exist in at least five forms: cytosine (C), 5-methylcytosine (5mC), 5-hydroxymethylcytosine (5hmC), 5-
formylcytosine (5fC) and 5-carboxylcytosine (5caC). DNA methyltransferases methylate cytosine at the 5-
position, generating 5mC in the genome. Ten-eleven translocation (Tet) dioxygenases convert 5mC to 5hmC,
5fC, and 5caC in three consecutive oxidation reactions. These modifications are dynamically regulated during
development and cell differentiation. To understand the function of these modifications and the regulatory
mechanisms that control the levels and genomic distribution of the five forms of the cytosine, we propose to
study the enzymes/proteins that generate, read, and remove these DNA modifications as well as associated
histone methylation.
摘要/摘要
哺乳动物中基因表达的控制部分依赖于DNA中胞嘧啶残基的修饰,
存在至少五种形式:胞嘧啶(C)、5-甲基胞嘧啶(5 mC)、5-羟甲基胞嘧啶(5 hmC)、5-甲基胞嘧啶(5 hm
甲酰胞嘧啶(5 fC)和5-羧基胞嘧啶(5caC)。DNA甲基转移酶甲基化胞嘧啶在5-
位置,在基因组中产生5 mC。10 - 11易位(泰特)双加氧酶将5 mC转化为5 hmC,
5 fC和5caC在三个连续的氧化反应。这些修改在过程中被动态地调节。
发育和细胞分化。为了了解这些修饰的功能和调控机制,
控制胞嘧啶的五种形式的水平和基因组分布的机制,我们建议
研究产生,读取和去除这些DNA修饰以及相关的酶/蛋白质
组蛋白甲基化
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Xiaodong Cheng其他文献
Xiaodong Cheng的其他文献
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{{ truncateString('Xiaodong Cheng', 18)}}的其他基金
Mutual reinforcement between somatic mutations and transcription factors in clonal hematopoiesis
克隆造血中体细胞突变和转录因子之间的相互强化
- 批准号:
10601791 - 财政年份:2023
- 资助金额:
$ 58.48万 - 项目类别:
Epigenetic regulations of DNA and histone methylation and deMethylation: Structures and Mechanisms
DNA 和组蛋白甲基化和去甲基化的表观遗传调控:结构和机制
- 批准号:
10544993 - 财政年份:2020
- 资助金额:
$ 58.48万 - 项目类别:
Epigenetic regulations of DNA and histone methylation and deMethylation: Structures and Mechanisms
DNA 和组蛋白甲基化和去甲基化的表观遗传调控:结构和机制
- 批准号:
10794474 - 财政年份:2020
- 资助金额:
$ 58.48万 - 项目类别:
Histone Lysine deMethylation: Structures, Inhibitions and Mechanisms
组蛋白赖氨酸去甲基化:结构、抑制和机制
- 批准号:
8861037 - 财政年份:2015
- 资助金额:
$ 58.48万 - 项目类别:
Histone Lysine deMethylation: Structures, Inhibitions and Mechanisms
组蛋白赖氨酸去甲基化:结构、抑制和机制
- 批准号:
9039106 - 财政年份:2015
- 资助金额:
$ 58.48万 - 项目类别:
Cell therapy for diabetic peripheral neurovascular complications
细胞疗法治疗糖尿病周围神经血管并发症
- 批准号:
8241514 - 财政年份:2011
- 资助金额:
$ 58.48万 - 项目类别:
DNA Methylation: Structures, Functions, and Regulation
DNA 甲基化:结构、功能和调控
- 批准号:
8123687 - 财政年份:2010
- 资助金额:
$ 58.48万 - 项目类别:
Generation of Induced Pluripotent Stem Cells with Novel Small Molecule Regulator
使用新型小分子调节剂生成诱导多能干细胞
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7836639 - 财政年份:2010
- 资助金额:
$ 58.48万 - 项目类别:
Histone Lysine Methylation: Structures and Functions
组蛋白赖氨酸甲基化:结构和功能
- 批准号:
8124458 - 财政年份:2010
- 资助金额:
$ 58.48万 - 项目类别:
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