2008 FASEB Summer Research Conference on Biological Methylation: from DNA to Hist

描述(由申请人提供) 该提案要求为2008年夏季美国实验生物学学会联合会“生物甲基化：从DNA到组蛋白”会议提供部分资金(~25%)。会议将集中讨论表观遗传甲基化及其对人类疾病的影响的前沿研究，这是NIEHS目前的主要任务之一。会议将于2008年6月1日至6日(周日至周五)在亚利桑那州无忧无虑的度假村举行。FASE B生物甲基化会议是该领域最激动人心和最重要的会议之一，大约150名科学家(包括许多知名女科学家、年轻科学家、研究生和博士后研究员)齐聚一堂，协调、交流和传播信息，并探索与人类疾病有关的表观遗传因素(如环境因素、个人易感性和年龄)。从提交的摘要中选出的一位主旨发言人、9位会议主席、36位特邀演讲者和18位演讲者(年轻科学家)将讨论以下9个主要主题：1)真核细胞胞嘧啶甲基转移酶；2)DNA甲基化与组蛋白甲基化；3)组蛋白赖氨酸甲基化与识别；4)蛋白质精氨酸甲基化；5)DNA甲基化与疾病；6)表观遗传学与癌症；7)组蛋白去甲基化；8)组蛋白或核酸以外的甲基化；以及9)小分子酶抑制剂。此外，下午还为年轻调查人员举办了三场小型研讨会。

DESCRIPTION (provided by applicant) This proposal requests partial funding (~25%) for 2008 Summer FASEB (Federation of American Societies for Experimental Biology) conference on "Biological Methylation: from DNA to Histones". The meeting will focus on the forefront research of epigenetic methylation and its influences on human illnesses, which is one of the current major missions of the NIEHS. The conference will be held in the Carefree Resort, Carefree, Arizona, from June 1-6, 2008 (Sunday-Friday). The FASEB Biological Methylation Conference is one of the most stimulating and important meetings in the field, where approximately 150 scientists (including many established women scientists, younger scientists, graduate students, and postdoctoral fellows) assemble to coordinate, exchange, and disseminate information and to explore epigenetic factors (such as environmental factors, individual susceptibility and age) on human illnesses. One keynote speaker, 9 session chairs, 36 invited speakers and 18 speakers (young scientists) selected from submitted abstracts will address the following 9 major themes: 1) eukaryotic cytosine methyltransferases; 2) link DNA methylation to histone methylation; 3) histone lysine methylation and recognition; 4) protein arginine methylation; 5) DNA methylation and diseases; 6) epigenetics and cancers; 7) histone demethylation; 8) methylation other than histones or nucleic acids; and, 9) small molecule enzyme inhibitors. In addition, three afternoon mini-symposia are devoted to young investigators.