Bridging the evidence-to-practice gap: Evaluating practice facilitation as a strategy to accelerate translation of a systems-level adherence intervention into safety net practices

弥合证据与实践之间的差距：评估实践促进作为加速将系统级依从性干预转化为安全网实践的策略

• 批准号: 10318079
• 负责人: OLUGBENGA G. OGEDEGBE
• 金额: $ 71.42万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-09 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10318079
• 关键词: Address; Adherence; Adult; Affect; Antihypertensive Agents; Attitude; Awareness; Black Populations; Blood Pressure; Caring; Clinic; Clinic Visits; Clinical; Cluster randomized trial; Consolidated Framework for Implementation Research; Data; Dimensions; Effectiveness; Electronic Health Record; Ensure; Ethnic group; Evidence based intervention; Evidence based practice; Family health status; Feedback; Health; Health Care Reform; Hypertension; Individual; Intervention; Knowledge; Latino; Latino Population; Laws; Learning; Medical; Medical Care Team; Methods; Minority Groups; Modeling; New York City; Not Hispanic or Latino; Outcome; Patient-Centered Care; Patients; Pharmaceutical Preparations; Pharmacy facility; Phase; Prevalence; Preventive screening; Primary Care Physician; Primary Health Care; Proctor framework; Randomized Controlled Trials; Records; Research; Sampling; Self-Direction; Standardization; System; Testing; Time; Translating; Translation Process; Translations; Vulnerable Populations; Work; arm; base; blood pressure control; breast exam; clinical outcome measures; clinical practice; design; disparity reduction; effectiveness evaluation; efficacious intervention; evidence base; formative assessment; health care quality; health care service; health care settings; health goals; hypertension control; hypertension treatment; hypertensive; implementation facilitation; implementation fidelity; implementation outcomes; implementation strategy; improved; medication compliance; motivational enhancement therapy; patient-level barriers; personalized approach; practice factors; primary care setting; primary outcome; racial and ethnic; response; routine care; routine practice; safety net; secondary outcome; skills; statistics; systematic review; treatment as usual

Project Summary: Despite increasing awareness and treatment of hypertension (HTN) across all racial/ethnic groups, Latinos have the lowest blood pressure (BP) control rates in the US (Latino adults: 34% vs. 43% and 53% in non-Hispanic black and white adults). These statistics may be explained by the disproportionately poorer adherence to antihypertensive medications among Latinos compared to blacks and whites. Systems- level interventions conducted in primary care settings have improved medication adherence in minority populations. Our Ayudando a Latinos Hipertensos Para Mejorar Adherencia a sus Medicamentos (ALMA) trial, which informs this proposal significantly improved both BP control (51 vs. 29%, p=.04) and medication adherence (78 vs. 72%, p=.02) compared to enhanced usual care in a sample of 119 Latino patients followed in a safety-net practice. Despite their efficacy, evidence-based interventions like ALMA often take up to 17 years to be translated into clinical practice. Implementation strategies are sorely needed to accelerate the translation of evidence-based interventions into routine “real world” safety-net practices, in order to reduce disparities in BP control in vulnerable populations. Practice facilitation (PF) is one method to accelerate the implementation of evidence-based interventions into healthcare settings. Through PF, a facilitator works with healthcare teams to develop the skills to adapt and implement evidence-based system changes and promotes a tailored approach to integrating those changes into the clinic workflow. Although evidence supports the effect of PF for preventive screenings (e.g., breast examination), its impact on implementing evidence-based systems approaches to support HTN management in safety-net practices remains largely untested. This proposal provides an opportunity to fill this evidence-to-practice gap by evaluating the effectiveness of PF as a practical and replicable strategy for implementing ALMA in a network of 12 safety-net Family Health Centers (FHCs) in New York City. Using a mixed-methods design, we will conduct this study in two phases: (1) A pre- implementation phase where we will refine the PF strategy, informed by our prior work, based on the Consolidated Framework for Implementation Research to facilitate the implementation of ALMA at the FHCs. (2) An implementation phase, during which we will evaluate, in a pragmatic cluster-randomized controlled trial, the effect of the PF strategy compared to a self-directed condition (i.e., receipt of information for implementing ALMA but no facilitation) on implementation fidelity (primary outcome) of ALMA and on clinical outcomes (secondary outcome) at 12 months among a sample of 650 Latinos with uncontrolled HTN cared for at the FHCs. Implementation fidelity will be assessed using a mixed methods approach based on the five core dimensions of implementation fidelity, as defined by Proctor’s Implementation Outcomes Framework. Clinical outcome measures include BP control (defined as <140/90 mmHg) and medication adherence (assessed using the proportion of days covered via pharmacy records).

项目总结：尽管所有种族/民族对高血压（HTN）的认识和治疗不断提高