Neural Mechanisms of Mindfulness-Based Stress Reduction in Adults with Autism Spectrum Disorder

患有自闭症谱系障碍的成人正念减压的神经机制

• 批准号: 10320735
• 负责人: Broc Anthony Pagni
• 金额: $ 3.96万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-01-11 至 2024-01-10
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10320735
• 关键词: Adult; Alzheimer' s Disease; Anxiety; Arizona; Automobile Driving; Awareness; Bayesian Method; Bayesian Modeling; Beck depression inventory; Behavior Therapy; Behavioral; Biological Markers; Brain; Brain Mapping; Clinical; Clinical Research; Clinical Trials; Cognitive; Collaborations; Communities; Complement; Control Groups; Data; Data Collection; Development; Diagnosis; Doctor of Philosophy; Education; Educational Intervention; Electroencephalography; Emotional; Emotions; Environment; Event-Related Potentials; Foundations; Functional Magnetic Resonance Imaging; Funding; Future; General Population; Goals; Imaging Techniques; Impairment; Independent Living; Institutes; Institution; Integrative Medicine; Intervention; Laboratories; Lead; Learning; Least-Squares Analysis; Measures; Mental Depression; Mentors; Methods; Mind; Mindfulness Training; Molecular; Mood Disorders; Moods; Multivariate Analysis; Neurologic; Occupations; Outcome; Parents; Participant; Pharmacology; Phenotype; Positioning Attribute; Prediction of Response to Therapy; Process; Property; Psychology; Quality of life; Randomized; Regulation; Relaxation; Research; Sample Size; Self-Examination; Signal Transduction; Social support; Somatosensory Cortex; Standardization; Stimulus; Support Groups; Techniques; Therapeutic; Therapeutic Effect; Therapy Clinical Trials; Time; Training; Universities; Work; adult with autism spectrum disorder; antidepressant effect; autism spectrum disorder; autistic children; base; behavioral pharmacology; brain behavior; causal model; cingulate cortex; comorbid depression; comorbidity; cost; depressive symptoms; emotion regulation; functional magnetic resonance imaging/electroencephalography; improved; individuals with autism spectrum disorder; mindfulness intervention; mindfulness-based stress reduction; mood symptom; multimodality; neural circuit; neural network; neurobiological mechanism; neuroimaging; neuroimaging marker; neuromechanism; neurophysiology; notch protein; programs; reduce symptoms; relating to nervous system; response; supportive environment; theories; therapeutic target; therapy outcome; tool

Project Summary/Abstract Adults with autism spectrum disorder (ASD) suffer from depression at up to four times the rate of the general population. Mindfulness-Based Stress Reduction (MBSR), a standardized 8-week intervention, is effective in treating mood comorbidities in ASD. In our data, MBSR participation elicited increased middle cingulate cortex activity during self-reflection, which correlated with depression reduction. Further, MBSR appears to modulate a neurophysiological marker of emotion regulation implicated in depression. The long-term goal of this research is to elucidate the neurobiological mechanisms driving MBSR’s therapeutic effects in adults with ASD. The specific aims of this proposal are to characterize MBSR-induced changes to 1) self-reflection neurocircuitry via effective connectivity and 2) emotional regulation neurophysiology. Significance: This study will identify multimodal brain dynamics underlying MBSR’s therapeutic effects in adults with ASD. Findings will inform biologically-based interventions for integrative health. Methods: Aim 1 leverages state-of-the-art effective connectivity brain mapping of self-reflection functional MRI; Aim 2 utilizes emotional regulation EEG data to capture neurophysiological event-related potentials. Exploratory Aim 3 will identify the combination of brain measures that best predicts depression reduction. Mr. Pagni aspires to become a leader in using multimodal neural imaging techniques to identify neural network properties that support long-term therapeutic and cognitive outcomes. His long-term goal is to lead an interdisciplinary clinical laboratory dedicated to understanding the brain basis of integrative health practices. As a behavioral technician, he provided applied behavioral therapy for children with ASD. Early in his Ph.D. program, he performed behavioral pharmacology research, equipping him with a foundation in cellular and molecular mechanisms driving depressive phenotypes. In his current lab, he has gained expertise in mindfulness-based therapies; fMRI analyses in ASD; and EEG data collection. The training plan will fulfill the following goals to complement his current expertise: 1) advanced fMRI analysis (effective connectivity); 2) EEG analysis (event- related potential); 3) brain-behavior relationships (partial least squares) and 4) ASD therapies and clinical trials. Training in neuroimaging methods and clinical trials will occur primarily at Arizona State University (ASU). ASU is a well-regarded, R1 institution with collaborations at Barrow Neurological Institute’s top-notch neuroimaging facilities. Mr. Pagni will receive additional state-of-the-art neuroimaging analysis training at Banner Alzheimer’s Institute. ASU’s Psychology Department also affords Mr. Pagni an optimal environment for implementing EEG techniques and learning best practices in clinical trial research. Together these institutes provide a supportive environment for Mr. Pagni to excel in multimodal brain analyses. In addition to the proposed goals, training will focus on professional development and dissemination of findings to the broader community.

项目概要/摘要 患有自闭症谱系障碍 (ASD) 的成年人患抑郁症的几率是普通人的四倍 人口。基于正念的减压 (MBSR) 是一项为期 8 周的标准化干预措施，可有效 治疗自闭症谱系障碍 (ASD) 的情绪合并症。在我们的数据中，MBSR 的参与引起了中扣带皮层的增加 自我反思期间的活动，这与抑郁的减少相关。此外，MBSR 似乎可以调节 与抑郁症有关的情绪调节的神经生理学标志。这项研究的长期目标是 阐明驱动 MBSR 对成人 ASD 治疗效果的神经生物学机制。具体的 该提案的目的是通过有效的方法来描述 MBSR 引起的 1) 自我反思神经回路的变化 连接性和2）情绪调节神经生理学。意义：这项研究将确定多模式大脑 MBSR 对患有自闭症谱系障碍 (ASD) 的成人患者的治疗效果背后的动态。研究结果将为基于生物学的 综合健康干预措施。方法：目标 1 利用最先进的有效连接大脑 自反射功能 MRI 绘图；目标 2 利用情绪调节脑电图数据来捕获 神经生理事件相关电位。探索性目标 3 将确定大脑测量的组合 这最能预测抑郁症的减轻。 Pagni先生渴望成为使用多模态神经成像技术识别神经网络的领导者 支持长期治疗和认知结果的特性。他的长期目标是领导 跨学科临床实验室致力于了解综合健康实践的大脑基础。作为 作为一名行为技术员，他为患有自闭症谱系障碍的儿童提供应用行为治疗。在他的博士学位早期。程序， 他进行了行为药理学研究，为他奠定了细胞和分子基础 驱动抑郁表型的机制。在他目前的实验室中，他获得了基于正念的专业知识 疗法；自闭症谱系障碍 (ASD) 的功能磁共振成像 (fMRI) 分析；和脑电图数据收集。培训计划将实现以下目标 补充他目前的专业知识：1）先进的功能磁共振成像分析（有效连接）； 2）脑电图分析（事件- 相关潜力）； 3) 大脑行为关系（偏最小二乘法）和 4) ASD 疗法和临床试验。 神经影像方法和临床试验的培训将主要在亚利桑那州立大学（ASU）进行。亚利桑那州立大学 是一家备受推崇的 R1 机构，与巴罗神经学研究所的一流神经影像学合作 设施。 Pagni 先生将在班纳阿尔茨海默病中心接受额外的最先进的神经影像分析培训 研究所。亚利桑那州立大学的心理学系还为 Pagni 先生提供了实施脑电图的最佳环境 技术和学习临床试验研究的最佳实践。这些机构共同提供支持 帕尼先生在多模式大脑分析方面表现出色的环境。除了拟议的目标外，培训还将 专注于专业发展和向更广泛的社区传播研究结果。