Neural Mechanisms of Mindfulness-Based Stress Reduction in Adults with Autism Spectrum Disorder

患有自闭症谱系障碍的成人正念减压的神经机制

• 批准号: 10541136
• 负责人: Broc Anthony Pagni
• 金额: $ 0.23万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-01-11 至 2023-01-12
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10541136
• 关键词: Adult; Alzheimer' s Disease; Anxiety; Arizona; Automobile Driving; Awareness; Bayesian Modeling; Beck depression inventory; Behavior; Behavior Therapy; Behavioral; Biological Markers; Brain; Brain Mapping; Clinical; Clinical Research; Clinical Trials; Cognitive; Cognitive Therapy; Collaborations; Communities; Complement; Control Groups; Data; Data Collection; Dedications; Development; Diagnosis; Doctor of Philosophy; Education; Educational Intervention; Electroencephalography; Emotional; Emotions; Environment; Event-Related Potentials; Foundations; Functional Magnetic Resonance Imaging; Funding; Future; General Population; Goals; Imaging Techniques; Impairment; Independent Living; Institution; Integrative Medicine; Intervention; Laboratories; Lead; Learning; Least-Squares Analysis; Measures; Mental Depression; Mentors; Methods; Mind; Mindfulness Training; Molecular; Mood Disorders; Moods; Multivariate Analysis; Neurologic; Occupations; Outcome; Parents; Participant; Phenotype; Positioning Attribute; Prediction of Response to Therapy; Process; Property; Psychology; Quality of life; Randomized; Relaxation; Research; Sample Size; Self-Examination; Signal Transduction; Social support; Somatosensory Cortex; Standardization; Stimulus; Support Groups; Techniques; Therapeutic; Therapeutic Effect; Training; Universities; Work; adult with autism spectrum disorder; antidepressant effect; autism spectrum disorder; autistic children; behavioral pharmacology; brain behavior; causal model; cingulate cortex; comorbid depression; comorbidity; cost; depressive symptoms; emotion regulation; functional magnetic resonance imaging/electroencephalography; improved; individuals with autism spectrum disorder; mindfulness intervention; mindfulness-based stress reduction; mood symptom; multimodality; neural; neural circuit; neural network; neurobiological mechanism; neuroimaging; neuroimaging marker; neuromechanism; neurophysiology; notch protein; pharmacologic; programs; reduce symptoms; response; supportive environment; theories; therapeutic target; therapy outcome; tool

Project Summary/Abstract Adults with autism spectrum disorder (ASD) suffer from depression at up to four times the rate of the general population. Mindfulness-Based Stress Reduction (MBSR), a standardized 8-week intervention, is effective in treating mood comorbidities in ASD. In our data, MBSR participation elicited increased middle cingulate cortex activity during self-reflection, which correlated with depression reduction. Further, MBSR appears to modulate a neurophysiological marker of emotion regulation implicated in depression. The long-term goal of this research is to elucidate the neurobiological mechanisms driving MBSR’s therapeutic effects in adults with ASD. The specific aims of this proposal are to characterize MBSR-induced changes to 1) self-reflection neurocircuitry via effective connectivity and 2) emotional regulation neurophysiology. Significance: This study will identify multimodal brain dynamics underlying MBSR’s therapeutic effects in adults with ASD. Findings will inform biologically-based interventions for integrative health. Methods: Aim 1 leverages state-of-the-art effective connectivity brain mapping of self-reflection functional MRI; Aim 2 utilizes emotional regulation EEG data to capture neurophysiological event-related potentials. Exploratory Aim 3 will identify the combination of brain measures that best predicts depression reduction. Mr. Pagni aspires to become a leader in using multimodal neural imaging techniques to identify neural network properties that support long-term therapeutic and cognitive outcomes. His long-term goal is to lead an interdisciplinary clinical laboratory dedicated to understanding the brain basis of integrative health practices. As a behavioral technician, he provided applied behavioral therapy for children with ASD. Early in his Ph.D. program, he performed behavioral pharmacology research, equipping him with a foundation in cellular and molecular mechanisms driving depressive phenotypes. In his current lab, he has gained expertise in mindfulness-based therapies; fMRI analyses in ASD; and EEG data collection. The training plan will fulfill the following goals to complement his current expertise: 1) advanced fMRI analysis (effective connectivity); 2) EEG analysis (event- related potential); 3) brain-behavior relationships (partial least squares) and 4) ASD therapies and clinical trials. Training in neuroimaging methods and clinical trials will occur primarily at Arizona State University (ASU). ASU is a well-regarded, R1 institution with collaborations at Barrow Neurological Institute’s top-notch neuroimaging facilities. Mr. Pagni will receive additional state-of-the-art neuroimaging analysis training at Banner Alzheimer’s Institute. ASU’s Psychology Department also affords Mr. Pagni an optimal environment for implementing EEG techniques and learning best practices in clinical trial research. Together these institutes provide a supportive environment for Mr. Pagni to excel in multimodal brain analyses. In addition to the proposed goals, training will focus on professional development and dissemination of findings to the broader community.

项目总结/摘要 患有自闭症谱系障碍（ASD）的成年人患抑郁症的几率是普通人的四倍。 人口正念减压（MBSR）是一种为期8周的标准化干预措施， 治疗ASD中的情绪共病在我们的数据中，正念减压疗法的参与引起了中扣带皮层的增加， 在自我反省期间的活动，这与抑郁症的减少有关。此外，正念减压疗法似乎可以调节 神经生理学标记的情绪调节牵连抑郁症。这项研究的长期目标是 阐明正念减压疗法治疗成人ASD的神经生物学机制。具体 这项建议的目的是表征MBSR诱导的变化，1）通过有效的自我反射神经回路， 连接和2）情绪调节神经生理学。意义：本研究将识别多模态脑 正念减压疗法在成人ASD治疗中的作用。研究结果将为基于生物学的 综合健康干预措施。方法：目标1利用最先进的有效大脑连接 自我反射功能性MRI的映射;目的2利用情绪调节EEG数据捕获 神经生理学事件相关电位探索性目标3将确定大脑测量的组合 最能预测抑郁症的减轻。 先生Pagni渴望成为使用多模态神经成像技术识别神经网络的领导者 支持长期治疗和认知结果的特性。他的长期目标是领导一个 跨学科临床实验室致力于了解综合健康实践的大脑基础。作为 作为一名行为技术人员，他为自闭症儿童提供应用行为疗法。早在他的博士学位。程序， 他进行了行为药理学研究，为他奠定了细胞和分子方面的基础 导致抑郁症的机制在他目前的实验室中，他获得了基于正念的专业知识 治疗; ASD中的fMRI分析;和EEG数据收集。培训计划将实现以下目标， 补充他目前的专业知识：1）先进的功能磁共振成像分析（有效连接）; 2）脑电图分析（事件- 相关电位）; 3）脑行为关系（偏最小二乘法）和4）ASD治疗和临床试验。 神经影像学方法和临床试验的培训将主要在亚利桑那州立大学（ASU）进行。ASU 是一个备受推崇的R1机构，与巴罗神经学研究所的一流神经影像学 设施帕尼先生将在班纳阿尔茨海默氏症接受额外的最先进的神经成像分析培训 院亚利桑那州立大学的心理学系也为Pagni先生提供了实施EEG的最佳环境 技术和学习临床试验研究的最佳实践。这些机构共同提供了一个支持 Pagni先生擅长多模式大脑分析的环境。除了拟议的目标外，培训将 注重专业发展和向更广泛的社区传播调查结果。

项目成果

Early Reflections on the Therapeutic Effects of Mindfulness-Based Therapies in Adults with Autism and Suggestions for Future Research.

对成人自闭症正念疗法治疗效果的早期反思以及对未来研究的建议。

• DOI: 10.20900/jpbs20210013
• 发表时间: 2021
• 期刊: Journal of psychiatry and brain science
• 作者: Pagni,BrocA;Braden,BBlair
• 通讯作者: Braden,BBlair