Neural Mechanisms of Mindfulness-Based Stress Reduction in Adults with Autism Spectrum Disorder

患有自闭症谱系障碍的成人正念减压的神经机制

• 批准号: 10541136
• 负责人: Broc Anthony Pagni
• 金额: $ 0.23万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-01-11 至 2023-01-12
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10541136
• 关键词: Adult; Alzheimer' s Disease; Anxiety; Arizona; Automobile Driving; Awareness; Bayesian Modeling; Beck depression inventory; Behavior; Behavior Therapy; Behavioral; Biological Markers; Brain; Brain Mapping; Clinical; Clinical Research; Clinical Trials; Cognitive; Cognitive Therapy; Collaborations; Communities; Complement; Control Groups; Data; Data Collection; Dedications; Development; Diagnosis; Doctor of Philosophy; Education; Educational Intervention; Electroencephalography; Emotional; Emotions; Environment; Event-Related Potentials; Foundations; Functional Magnetic Resonance Imaging; Funding; Future; General Population; Goals; Imaging Techniques; Impairment; Independent Living; Institution; Integrative Medicine; Intervention; Laboratories; Lead; Learning; Least-Squares Analysis; Measures; Mental Depression; Mentors; Methods; Mind; Mindfulness Training; Molecular; Mood Disorders; Moods; Multivariate Analysis; Neurologic; Occupations; Outcome; Parents; Participant; Phenotype; Positioning Attribute; Prediction of Response to Therapy; Process; Property; Psychology; Quality of life; Randomized; Relaxation; Research; Sample Size; Self-Examination; Signal Transduction; Social support; Somatosensory Cortex; Standardization; Stimulus; Support Groups; Techniques; Therapeutic; Therapeutic Effect; Training; Universities; Work; adult with autism spectrum disorder; antidepressant effect; autism spectrum disorder; autistic children; behavioral pharmacology; brain behavior; causal model; cingulate cortex; comorbid depression; comorbidity; cost; depressive symptoms; emotion regulation; functional magnetic resonance imaging/electroencephalography; improved; individuals with autism spectrum disorder; mindfulness intervention; mindfulness-based stress reduction; mood symptom; multimodality; neural; neural circuit; neural network; neurobiological mechanism; neuroimaging; neuroimaging marker; neuromechanism; neurophysiology; notch protein; pharmacologic; programs; reduce symptoms; response; supportive environment; theories; therapeutic target; therapy outcome; tool

Project Summary/Abstract Adults with autism spectrum disorder (ASD) suffer from depression at up to four times the rate of the general population. Mindfulness-Based Stress Reduction (MBSR), a standardized 8-week intervention, is effective in treating mood comorbidities in ASD. In our data, MBSR participation elicited increased middle cingulate cortex activity during self-reflection, which correlated with depression reduction. Further, MBSR appears to modulate a neurophysiological marker of emotion regulation implicated in depression. The long-term goal of this research is to elucidate the neurobiological mechanisms driving MBSR’s therapeutic effects in adults with ASD. The specific aims of this proposal are to characterize MBSR-induced changes to 1) self-reflection neurocircuitry via effective connectivity and 2) emotional regulation neurophysiology. Significance: This study will identify multimodal brain dynamics underlying MBSR’s therapeutic effects in adults with ASD. Findings will inform biologically-based interventions for integrative health. Methods: Aim 1 leverages state-of-the-art effective connectivity brain mapping of self-reflection functional MRI; Aim 2 utilizes emotional regulation EEG data to capture neurophysiological event-related potentials. Exploratory Aim 3 will identify the combination of brain measures that best predicts depression reduction. Mr. Pagni aspires to become a leader in using multimodal neural imaging techniques to identify neural network properties that support long-term therapeutic and cognitive outcomes. His long-term goal is to lead an interdisciplinary clinical laboratory dedicated to understanding the brain basis of integrative health practices. As a behavioral technician, he provided applied behavioral therapy for children with ASD. Early in his Ph.D. program, he performed behavioral pharmacology research, equipping him with a foundation in cellular and molecular mechanisms driving depressive phenotypes. In his current lab, he has gained expertise in mindfulness-based therapies; fMRI analyses in ASD; and EEG data collection. The training plan will fulfill the following goals to complement his current expertise: 1) advanced fMRI analysis (effective connectivity); 2) EEG analysis (event- related potential); 3) brain-behavior relationships (partial least squares) and 4) ASD therapies and clinical trials. Training in neuroimaging methods and clinical trials will occur primarily at Arizona State University (ASU). ASU is a well-regarded, R1 institution with collaborations at Barrow Neurological Institute’s top-notch neuroimaging facilities. Mr. Pagni will receive additional state-of-the-art neuroimaging analysis training at Banner Alzheimer’s Institute. ASU’s Psychology Department also affords Mr. Pagni an optimal environment for implementing EEG techniques and learning best practices in clinical trial research. Together these institutes provide a supportive environment for Mr. Pagni to excel in multimodal brain analyses. In addition to the proposed goals, training will focus on professional development and dissemination of findings to the broader community.

项目摘要/摘要 自闭症谱系障碍（ASD）的成年人患抑郁症的最多是一般率的四倍 人口。基于正念的压力减轻（MBSR）是一种标准化的8周干预，有效 治疗ASD的情绪合并症。在我们的数据中，MBSR参与引起了增加的扣带回皮质 自我反射期间的活性与减轻抑郁症相关。此外，MBSR似乎调节了 情绪调节的神经生理标记与抑郁有关。这项研究的长期目标是 为了阐明神经生物学机制在ASD成年人中推动了MBSR的治疗作用。具体 该建议的目的是表征MBSR诱导的变化1）通过有效的自我反射神经循环。 连通性和2）情绪调节神经生理学。意义：这项研究将确定多模式的大脑 MBSR在ASD成年人中的治疗作用的动力。调查结果将为基于生物学的 综合健康的干预措施。方法：目标1杠杆最先进的有效连通性大脑 自我反射功能MRI的映射； AIM 2利用情绪调节脑电图数据捕获 神经生理事件相关的电位。探索性目标3将确定大脑测量的组合 最好的预测减少了抑郁症。 帕格尼先生渴望成为使用多模式神经成像技术来识别神经网络的领导者 支持长期治疗和认知结果的特性。他的长期目标是领导 跨学科的临床实验室致力于理解综合健康实践的大脑基础。作为 他是行为技术员，为ASD儿童提供了应用行为疗法。在他的博士学位初期程序， 他进行了行为药理学研究，为他提供了细胞和分子的基础 驱动抑郁表型的机制。在他目前的实验室中，他获得了基于正念的专业知识 疗法； ASD中的fMRI分析；和脑电图数据收集。培训计划将实现以下目标 补充他当前的专业知识：1）高级fMRI分析（有效连接）； 2）EEG分析（事件 - 相关潜力）； 3）脑行为关系（部分最小二乘）和4）ASD疗法和临床试验。 神经影像学方法和临床试验的培训将主要发生在亚利桑那州立大学（ASU）。 ASU 是一个备受推崇的R1机构，在Barrow神经学院的一流神经影像学上合作 设施。 Pagni先生将在阿尔茨海默氏症班纳（Banner Alzheimer）接受其他最先进的神经影像学分析培训 研究所。 ASU的心理学系还为Pagni先生提供了实施脑电图的最佳环境 临床试验研究中的技术和学习最佳实践。这些机构共同提供了支持 Pagni先生在多模式大脑分析中表现出色的环境。除了提出的目标外，培训还将 专注于专业发展和向更广泛社区的发现传播。

项目成果

Early Reflections on the Therapeutic Effects of Mindfulness-Based Therapies in Adults with Autism and Suggestions for Future Research.

对成人自闭症正念疗法治疗效果的早期反思以及对未来研究的建议。

• DOI: 10.20900/jpbs20210013
• 发表时间: 2021
• 期刊: Journal of psychiatry and brain science
• 作者: Pagni,BrocA;Braden,BBlair
• 通讯作者: Braden,BBlair