IMAGINE

IMAGINE项目将开发下一代跨尺度成像技术，以实现对生物系统结构和功能的综合研究。它将重点开发和集成四大破坏性显微技术，即：X射线成像、低温电子显微镜、低温和动态超分辨率显微镜以及大体积活体光学显微镜。它还将进一步开发人工智能支持的图像分析和数据集成/共享能力，这是将这些技术关联起来并使其数据广泛可用所需的能力。为了利用它们的力量应对一些最紧迫的社会挑战，Imagine将准备其新的成像技术，以便在实地部署在欧洲的海洋和海岸线上，以便收集自然环境中的环境标本，并利用最高分辨率的成像技术进行研究。IMAGINE技术目前处于物理学和工程学的前沿，因此只有孤立的专家才能使用。该项目旨在通过开发和验证它们的服务准备情况，将它们带到整个欧洲生命科学用户社区，以便它们可以作为欧洲研究基础设施(RIS)未来的服务提供。为此，该项目将就IMAGINE技术的操作和使用对国际扶轮工作人员进行培训。为了促进作为商业仪器的广泛传播，IMAGINE将在学术界和行业之间联合开发技术，促进与成像领域的主要仪器制造商的开放创新。生命科学界越来越依赖RIS来获取越来越复杂和快速发展的科学仪器。IMAGINE开发的跨尺度成像技术将对推动欧洲的突破性研究至关重要，这是解决我们社会未来将面临的一些最大挑战所迫切需要的。

The IMAGINE project will develop the next generation of scale-crossing imaging technologies to enable an integrated investigation of structure and function of biological systems. It will focus on developing and integrating four major disruptive microscopy technologies, namely: X-ray imaging, cryo electron microscopy, cryo and dynamic super-resolution microscopy and large volume intravital light microscopy. It will furthermore develop the AI-powered image analysis and data integration/sharing capabilities, that are needed to correlate these technologies and make their data widely available. To harness their power for some of the most pressing societal challenges, IMAGINE will prepare its new imaging technologies to be deployed in the field, on Europe’s seas and coastlines, so that the collection of environmental specimen in their natural context can be coupled with their study by highest resolution imaging technologies. The IMAGINE technologies are currently at the cutting edge of physics and engineering and therefore only available in isolation and to specialists. The project aims to bring them to the European life science user community at large by developing and validating them for service readiness, so that they can be provided as future services by Europe’s Research Infrastructures (RIs). To this end, the project will train RI staff on the operation and use of the IMAGINE technologies. To promote broad dissemination as commercial instruments, IMAGINE will develop technologies jointly between academia and industry promoting open innovation with key instrumentation manufacturers in the imaging field. The life science community increasingly relies on RIs to access ever more complex and rapidly developing scientific instruments. The scale-crossing imaging technologies developed by IMAGINE will be critical to empower groundbreaking research in Europe, that is so urgently needed to address some of the biggest challenges our societies will face in the future.