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IMAGINE

想象

基本信息

批准号：
10048356
负责人：
金额：
$ 30.6万
依托单位：
THE ROSALIND FRANKLIN INSTITUTE
依托单位国家：
英国
项目类别：
EU-Funded
财政年份：
2023
资助国家：
英国
起止时间：
2023 至无数据
项目状态：
未结题

来源：
https://gtr.ukri.org/projects?ref=10048356
关键词：
IMAGINE

项目摘要

The IMAGINE project will develop the next generation of scale-crossing imaging technologies to enable an integrated investigation of structure and function of biological systems. It will focus on developing and integrating four major disruptive microscopy technologies, namely: X-ray imaging, cryo electron microscopy, cryo and dynamic super-resolution microscopy and large volume intravital light microscopy. It will furthermore develop the AI-powered image analysis and data integration/sharing capabilities, that are needed to correlate these technologies and make their data widely available. To harness their power for some of the most pressing societal challenges, IMAGINE will prepare its new imaging technologies to be deployed in the field, on Europe’s seas and coastlines, so that the collection of environmental specimen in their natural context can be coupled with their study by highest resolution imaging technologies. The IMAGINE technologies are currently at the cutting edge of physics and engineering and therefore only available in isolation and to specialists. The project aims to bring them to the European life science user community at large by developing and validating them for service readiness, so that they can be provided as future services by Europe’s Research Infrastructures (RIs). To this end, the project will train RI staff on the operation and use of the IMAGINE technologies. To promote broad dissemination as commercial instruments, IMAGINE will develop technologies jointly between academia and industry promoting open innovation with key instrumentation manufacturers in the imaging field. The life science community increasingly relies on RIs to access ever more complex and rapidly developing scientific instruments. The scale-crossing imaging technologies developed by IMAGINE will be critical to empower groundbreaking research in Europe, that is so urgently needed to address some of the biggest challenges our societies will face in the future.

IMAGINE项目将开发下一代跨尺度成像技术，以便能够对生物系统的结构和功能进行综合调查。它将专注于开发和集成四种主要的颠覆性显微技术，即：X射线成像、冷冻电子显微镜、冷冻和动态超分辨率显微镜以及大容量活体光学显微镜。它将进一步开发人工智能驱动的图像分析和数据集成/共享功能，这是将这些技术关联起来并使其数据广泛可用所需的。为了利用它们的力量来应对一些最紧迫的社会挑战，IMAGINE将准备将其新的成像技术部署在欧洲的海洋和海岸线上，以便在自然环境中收集环境标本，并通过最高分辨率的成像技术进行研究。IMAGINE技术目前处于物理学和工程学的前沿，因此只能单独提供给专家。该项目旨在通过开发和验证它们的服务就绪性，将它们带到欧洲生命科学用户社区，以便它们可以作为欧洲研究机构（RI）的未来服务提供。为此目的，该项目将培训扶轮社工作人员操作和使用IMAGINE技术。为了促进作为商业仪器的广泛传播，IMAGINE将在学术界和工业界之间联合开发技术，促进成像领域主要仪器制造商的开放式创新。生命科学界越来越依赖于RI来访问越来越复杂和快速发展的科学仪器。IMAGINE开发的跨尺度成像技术对于欧洲的突破性研究至关重要，这是解决我们社会未来面临的一些最大挑战所迫切需要的。