New England Gastropareis Consortium: Neurobiology of Gastroparesis

摘要 胃瘫的症状包括慢性恶心和呕吐、早饱、餐后饱胀、 腹胀，经常疼痛。虽然最初被概念化为肠道运动障碍 功能障碍(即胃排空延迟)，越来越多的研究表明：(1) 症状严重程度和排空严重程度，以及(2)针对运动的治疗大多无效 功能障碍。虽然胃瘫的原因可能是多因素的，但当疾病变成慢性时 症状的严重程度对生活质量(QOL)有很大的影响，复杂的病理可能 开始在肠道和中枢神经系统中进化，不仅仅是运动异常导致其他 感官缺陷。进一步分析胃瘫患者的生物心理社会结构是必要的。 可能成为新的干预措施的目标。为了实现这些目标，我们建议继续实施新的 英格兰胃瘫合作组织是NIH胃瘫联盟的一部分。多中心网络 将有助于招募我们的建议，进一步的胃瘫患者的特征登记和 胃瘫的各种多中心研究的继续。此外，我们的网站(马萨诸塞州总医院 医院；MGH)建议解决：(1)新的生物、心理和社会因素在维持中的贡献 和(2)认知行为疗法(CBT)治疗胃瘫的初步疗效。 胃瘫。

ABSTRACT Symptoms of gastroparesis include chronic nausea and vomiting, early satiation, postprandial fullness, abdominal distention and frequently pain. While initially conceptualized as a disorder of enteric motor dysfunction (i.e., delayed gastric emptying), growing research suggests both (1) a disconnect between symptom severity and emptying severity, and (2) largely ineffectiveness of treatments that target motor dysfunction. Although the causes of gastroparesis can be multi-factorial, when the disease becomes chronic and the severity of the symptoms result in a high impact on Quality of Life (QOL), complex pathologies may begin to evolve in the enteric and central nervous system beyond just motor abnormalities contributing to other sensory defects. Further profiling of biopsychosocial constructs in gastroparesis is needed, as such constructs could be targeted by novel interventions. To accomplish these goals, we propose to continue with the New England Gastroparesis Collaborative as part of the NIH Gastroparesis Consortium. The multi-center network will help recruit to our proposal of further gastroparesis patient characterization in the Registries and continuation of various multi-center studies for gastroparesis. In addition, our site (Massachusetts General Hospital; MGH) proposes addressing: (1) the contribution of novel biopsychosocial factors in the maintenance of gastroparesis symptoms, and (2) the preliminary efficacy of a cognitive behavioral therapy (CBT) for gastroparesis.