New England Gastropareis Consortium: Neurobiology of Gastroparesis

新英格兰胃轻瘫联盟：胃轻瘫的神经生物学

• 批准号: 10319778
• 负责人: Braden Kuo
• 金额: $ 42万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-25 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10319778
• 关键词: Abdomen; Address; Anxiety; Behavioral; Biological; Caring; Chronic; Clinical; Clinical Research; Clinical Trials; Cognitive Therapy; Complex; Defect; Disease; Eating; Elements; Enrollment; Enteral; Epidemiology; Functional Gastrointestinal Disorders; Functional disorder; Future; Gastrointestinal Diseases; Gastroparesis; General Hospitals; Goals; Health; Intervention; Irritable Bowel Syndrome; Maintenance; Massachusetts; Medical; Morbidity - disease rate; Motor; Multicenter Studies; Natural History; Nature; Nausea and Vomiting; Neuraxis; Neurobiology; New England; Pain; Pathology; Patient Self-Report; Patients; Peripheral; Phenotype; Protocols documentation; Pyloric sphincter structure; Quality of life; Randomized Controlled Trials; Registries; Research; Role; Screening procedure; Sensory; Severities; Site; Symptoms; Testing; Therapeutic; Treatment outcome; United States National Institutes of Health; Validation; Visceral; acceptability and feasibility; avoidant restrictive food intake disorder; behavioral health; behavioral health intervention; biopsychosocial; biopsychosocial factor; central sensitization; dietary restriction; early satiety; efficacious treatment; follow-up; food avoidance; gastrointestinal; gastrointestinal symptom; gut-brain axis; health care service utilization; improved; indexing; ineffective therapies; innovation; mortality; motor disorder; neuroregulation; novel; patient registry; precision medicine; primary endpoint; profiles in patients; psychologic; recruit; reduce symptoms; research study; restrictive eating; secondary endpoint; targeted treatment; video delivery

ABSTRACT Symptoms of gastroparesis include chronic nausea and vomiting, early satiation, postprandial fullness, abdominal distention and frequently pain. While initially conceptualized as a disorder of enteric motor dysfunction (i.e., delayed gastric emptying), growing research suggests both (1) a disconnect between symptom severity and emptying severity, and (2) largely ineffectiveness of treatments that target motor dysfunction. Although the causes of gastroparesis can be multi-factorial, when the disease becomes chronic and the severity of the symptoms result in a high impact on Quality of Life (QOL), complex pathologies may begin to evolve in the enteric and central nervous system beyond just motor abnormalities contributing to other sensory defects. Further profiling of biopsychosocial constructs in gastroparesis is needed, as such constructs could be targeted by novel interventions. To accomplish these goals, we propose to continue with the New England Gastroparesis Collaborative as part of the NIH Gastroparesis Consortium. The multi-center network will help recruit to our proposal of further gastroparesis patient characterization in the Registries and continuation of various multi-center studies for gastroparesis. In addition, our site (Massachusetts General Hospital; MGH) proposes addressing: (1) the contribution of novel biopsychosocial factors in the maintenance of gastroparesis symptoms, and (2) the preliminary efficacy of a cognitive behavioral therapy (CBT) for gastroparesis.

抽象的 胃轻瘫的症状包括慢性恶心和呕吐、早饱、餐后饱胀、 腹胀且经常疼痛。虽然最初被概念化为肠运动障碍 功能障碍（即胃排空延迟），越来越多的研究表明（1）两者之间存在脱节 症状严重程度和排空严重程度，以及（2）针对运动的治疗基本上无效 功能障碍。虽然胃轻瘫的原因可能是多因素的，但当疾病变成慢性时 并且症状的严重程度会对生活质量 (QOL) 产生很大影响，复杂的病理可能 开始在肠道和中枢神经系统中进化，而不仅仅是导致其他运动异常 感觉缺陷。需要进一步分析胃轻瘫的生物心理社会结构，因为这样的结构 可以作为新干预措施的目标。为了实现这些目标，我们建议继续实施新的 英格兰胃轻瘫协作组织是 NIH 胃轻瘫联盟的一部分。多中心网络 将有助于招募我们的提案，在登记处进一步描述胃轻瘫患者的特征，并 继续进行胃轻瘫的各种多中心研究。此外，我们的网站（马萨诸塞州综合 医院; MGH）建议解决：（1）新的生物心理社会因素在维持中的贡献 胃轻瘫症状，以及（2）认知行为疗法（CBT）对胃轻瘫症状的初步疗效 胃轻瘫。