New England Gastropareis Consortium: Neurobiology of Gastroparesis
新英格兰胃轻瘫联盟:胃轻瘫的神经生物学
基本信息
- 批准号:10842564
- 负责人:
- 金额:$ 6.18万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-09-25 至 2027-07-31
- 项目状态:未结题
- 来源:
- 关键词:Abdominal PainAdolescenceAdolescentAdultAncillary StudyAssessment toolCOVID-19 pandemic effectsCategoriesCharacteristicsChildChildhoodChronicClinicalClinical ResearchClinical TrialsConsentDataDevelopmentDiabetes MellitusDiseaseDistressDyspepsiaEpigastriumEtiologyFunctional Gastrointestinal DisordersFunctional disorderFutureGastric EmptyingGastroparesisGeneral PopulationGoalsHospitalizationIncidenceKnowledgeMeasuresMechanicsMethodologyMethodsMolecularMorbidity - disease rateNational Institute of Diabetes and Digestive and Kidney DiseasesNatural HistoryNausea and VomitingNeurobiologyNew EnglandNutritionalObstructionOperative Surgical ProceduresOutcome AssessmentPainPatientsPeriodicityPhysiologicalPopulationPrevalenceProcessProtocols documentationQuality of lifeQuestionnairesRegistriesResearchRomeSample SizeSeveritiesSeverity of illnessSiteSourceStomachSymptomsSyndromeTherapeutic Clinical TrialTherapeutic StudiesToddlerTreatment outcomeVomitingWorkadverse outcomeage groupage relatedcell motilitychronic abdominal painclinical carecohortcommon symptomcomorbiditycostdietaryearly satietyeffective therapygastrointestinalimprovedinnovationinsightinterdisciplinary approachmortalityneuropathologypediatric patientsprospectivepsychologicpsychosocialrecruit
项目摘要
ABSTRACT
Gastroparesis (Gp) in children and adults is characterized by delayed gastric emptying in the absence of
mechanical obstruction. GP is associated with significant morbidity and mortality, yet little is known regarding its
incidence, prevalence, and natural history in children. This knowledge gap in pediatric Gp is exacerbated by the
overlap in symptoms and pathophysiology with functional dyspepsia (FD), a common disorder in adults and
children. The limited data suggests significant differences between clinical symptoms and pathophysiology of
Gp and FD in children vs adults. Thus, data regarding Gp and FD in adults is unlikely to provide insight and fill
the knowledge gaps regarding Gp and FD in children. These issues (among others) underscore the need for
childhood Gp- and FD-specific research strategies. Thus, the goals of this supplemental application are to build
on and extend our Pediatric Gp Registry 2 (PGpR2) work as part of the NIDDK Gastroparesis Consortium
(GpCRC) ultimately, to determine the factors contributing to disease severity measured by quality of life and
symptoms. The Specific Aims of the current project are to:
Aim 1: Create a national prospective registry of children and adolescents with gastroparesis Gp) and Gp-like
syndrome (GLS; the latter group, using pediatric Rome IV criteria will be characterized as having FD (functional
dyspepsia, including the two subtypes [FD-EPS, FD-PDS]), chronic nausea vomiting syndrome, cyclic vomiting
syndrome, and/or chronic abdominal pain syndrome to include demographic, clinical, psychological, nutritional
characteristics, physiological measures, and serial assessments of symptoms over 3 years during their clinical
care.
Aim 2: Follow this well-characterized cohort to further define the natural history, clinical course, and selected
physiologic measures of children and adolescents with symptoms of Gp.
Aim 3: Provide a reliable source for recruitment of well-characterized children and adolescents with Gp and
FD for other studies including therapeutic clinical trials, pathophysiological, molecular, histopathologic, or other
ancillary studies. These subsequent clinical trials or ancillary studies will be conducted under separate study
protocols with separate consent processes.
Supplement Aim: Expand the number of pediatric sites within the PGpR2 to facilitate recruitment and
consequently, the goals of the PGpR2.
This innovative multidisciplinary approach will prospectively begin to fill the vast knowledge void regarding
Gp and FD in children. The current supplement proposal is responsive to RFA-DK-20-504 and PA-20-272 by
achieving among other goals, to build on our previous gains and expand the number of pediatric sites to enhance
recruitment.
摘要
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Colonic motor response to wakening is blunted in slow transit constipation as detected by wireless motility capsule.
无线运动胶囊检测到,在慢传输型便秘中,结肠运动对唤醒的反应减弱。
- DOI:10.1038/s41424-018-0012-9
- 发表时间:2018
- 期刊:
- 影响因子:3.6
- 作者:Surjanhata,Brian;Barshop,Kenneth;Staller,Kyle;Semler,Jack;Guay,Laurence;Kuo,Braden
- 通讯作者:Kuo,Braden
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Braden Kuo其他文献
Braden Kuo的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Braden Kuo', 18)}}的其他基金
Thoracic Neuromodulation for Diabetic Gastroparesis
胸神经调节治疗糖尿病胃轻瘫
- 批准号:
10504662 - 财政年份:2022
- 资助金额:
$ 6.18万 - 项目类别:
Thoracic Neuromodulation for Diabetic Gastroparesis
胸神经调节治疗糖尿病胃轻瘫
- 批准号:
10661838 - 财政年份:2022
- 资助金额:
$ 6.18万 - 项目类别:
TRANSLUMBOSACRAL NEUROMODULATION THERAPY FOR FECAL INCONTINENCE: RANDOMIZED TRIAL
经腰骶神经调节治疗大便失禁:随机试验
- 批准号:
9898357 - 财政年份:2019
- 资助金额:
$ 6.18万 - 项目类别:
TRANSLUMBOSACRAL NEUROMODULATION THERAPY FOR FECAL INCONTINENCE: RANDOMIZED TRIAL
经腰骶神经调节治疗大便失禁:随机试验
- 批准号:
10609483 - 财政年份:2019
- 资助金额:
$ 6.18万 - 项目类别:
TRANSLUMBOSACRAL NEUROMODULATION THERAPY FOR FECAL INCONTINENCE: RANDOMIZED TRIAL
经腰骶神经调节治疗大便失禁:随机试验
- 批准号:
10373002 - 财政年份:2019
- 资助金额:
$ 6.18万 - 项目类别:
New England Gastropareis Consortium: Neurobiology of Gastroparesis
新英格兰胃轻瘫联盟:胃轻瘫的神经生物学
- 批准号:
10319778 - 财政年份:2016
- 资助金额:
$ 6.18万 - 项目类别:
New England Gastropareis Consortium: Neurobiology of Gastroparesis
新英格兰胃轻瘫联盟:胃轻瘫的神经生物学
- 批准号:
10473954 - 财政年份:2016
- 资助金额:
$ 6.18万 - 项目类别:
New England Gastropareis Consortium: Neurobiology of Gastroparesis
新英格兰胃轻瘫联盟:胃轻瘫的神经生物学
- 批准号:
9357604 - 财政年份:2016
- 资助金额:
$ 6.18万 - 项目类别:
New England Gastropareis Consortium: Neurobiology of Gastroparesis
新英格兰胃轻瘫联盟:胃轻瘫的神经生物学
- 批准号:
10001523 - 财政年份:2016
- 资助金额:
$ 6.18万 - 项目类别:
Brain Mechanisms for Autonomic Outflow and Nausea in Cyclic Vomiting Syndrome
周期性呕吐综合征自主神经流出和恶心的脑机制
- 批准号:
8547073 - 财政年份:2012
- 资助金额:
$ 6.18万 - 项目类别:
相似海外基金
Identification of Prospective Predictors of Alcohol Initiation During Early Adolescence
青春期早期饮酒的前瞻性预测因素的鉴定
- 批准号:
10823917 - 财政年份:2024
- 资助金额:
$ 6.18万 - 项目类别:
Socio-Emotional Characteristics in Early Childhood and Offending Behaviour in Adolescence
幼儿期的社会情感特征和青春期的犯罪行为
- 批准号:
ES/Z502601/1 - 财政年份:2024
- 资助金额:
$ 6.18万 - 项目类别:
Fellowship
Cognitive and non-cognitive abilities and career development during adolescence and adult development: from the perspective of genetic and environmental structure
青春期和成人发展期间的认知和非认知能力与职业发展:从遗传和环境结构的角度
- 批准号:
23K02900 - 财政年份:2023
- 资助金额:
$ 6.18万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Reasoning about Spatial Relations and Distributions: Supporting STEM Learning in Early Adolescence
空间关系和分布的推理:支持青春期早期的 STEM 学习
- 批准号:
2300937 - 财政年份:2023
- 资助金额:
$ 6.18万 - 项目类别:
Continuing Grant
Does social motivation in adolescence differentially predict the impact of childhood threat exposure on developing suicidal thoughts and behaviors
青春期的社会动机是否可以差异预测童年威胁暴露对自杀想法和行为的影响
- 批准号:
10785373 - 财政年份:2023
- 资助金额:
$ 6.18万 - 项目类别:
Mapping the Neurobiological Risks and Consequences of Alcohol Use in Adolescence and Across the Lifespan
绘制青春期和整个生命周期饮酒的神经生物学风险和后果
- 批准号:
10733406 - 财政年份:2023
- 资助金额:
$ 6.18万 - 项目类别:
The Role of Sleep in the Relationships Among Adverse Childhood Experiences, Mental Health Symptoms, and Persistent/Recurrent Pain during Adolescence
睡眠在不良童年经历、心理健康症状和青春期持续/复发性疼痛之间关系中的作用
- 批准号:
10676403 - 财政年份:2023
- 资助金额:
$ 6.18万 - 项目类别:
Thalamo-prefrontal circuit maturation during adolescence
丘脑-前额叶回路在青春期成熟
- 批准号:
10585031 - 财政年份:2023
- 资助金额:
$ 6.18万 - 项目类别:
Interdisciplinary Perspectives on the Politics of Adolescence and Democracy
青少年政治与民主的跨学科视角
- 批准号:
EP/X026825/1 - 财政年份:2023
- 资助金额:
$ 6.18万 - 项目类别:
Research Grant
An Empirical Study on the Influence of Socioeconomic Status in Adolescence on Exercise Habits in Adulthood
青春期社会经济地位对成年期运动习惯影响的实证研究
- 批准号:
23K16734 - 财政年份:2023
- 资助金额:
$ 6.18万 - 项目类别:
Grant-in-Aid for Early-Career Scientists