New England Gastropareis Consortium: Neurobiology of Gastroparesis

新英格兰胃轻瘫联盟：胃轻瘫的神经生物学

• 批准号: 10842564
• 负责人: Braden Kuo
• 金额: $ 6.18万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-25 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10842564
• 关键词: Abdominal Pain; Adolescence; Adolescent; Adult; Ancillary Study; Assessment tool; COVID-19 pandemic effects; Categories; Characteristics; Child; Childhood; Chronic; Clinical; Clinical Research; Clinical Trials; Consent; Data; Development; Diabetes Mellitus; Disease; Distress; Dyspepsia; Epigastrium; Etiology; Functional Gastrointestinal Disorders; Functional disorder; Future; Gastric Emptying; Gastroparesis; General Population; Goals; Hospitalization; Incidence; Knowledge; Measures; Mechanics; Methodology; Methods; Molecular; Morbidity - disease rate; National Institute of Diabetes and Digestive and Kidney Diseases; Natural History; Nausea and Vomiting; Neurobiology; New England; Nutritional; Obstruction; Operative Surgical Procedures; Outcome Assessment; Pain; Patients; Periodicity; Physiological; Population; Prevalence; Process; Protocols documentation; Quality of life; Questionnaires; Registries; Research; Rome; Sample Size; Severities; Severity of illness; Site; Source; Stomach; Symptoms; Syndrome; Therapeutic Clinical Trial; Therapeutic Studies; Toddler; Treatment outcome; Vomiting; Work; adverse outcome; age group; age related; cell motility; chronic abdominal pain; clinical care; cohort; common symptom; comorbidity; cost; dietary; early satiety; effective therapy; gastrointestinal; improved; innovation; insight; interdisciplinary approach; mortality; neuropathology; pediatric patients; prospective; psychologic; psychosocial; recruit

ABSTRACT Gastroparesis (Gp) in children and adults is characterized by delayed gastric emptying in the absence of mechanical obstruction. GP is associated with significant morbidity and mortality, yet little is known regarding its incidence, prevalence, and natural history in children. This knowledge gap in pediatric Gp is exacerbated by the overlap in symptoms and pathophysiology with functional dyspepsia (FD), a common disorder in adults and children. The limited data suggests significant differences between clinical symptoms and pathophysiology of Gp and FD in children vs adults. Thus, data regarding Gp and FD in adults is unlikely to provide insight and fill the knowledge gaps regarding Gp and FD in children. These issues (among others) underscore the need for childhood Gp- and FD-specific research strategies. Thus, the goals of this supplemental application are to build on and extend our Pediatric Gp Registry 2 (PGpR2) work as part of the NIDDK Gastroparesis Consortium (GpCRC) ultimately, to determine the factors contributing to disease severity measured by quality of life and symptoms. The Specific Aims of the current project are to: Aim 1: Create a national prospective registry of children and adolescents with gastroparesis Gp) and Gp-like syndrome (GLS; the latter group, using pediatric Rome IV criteria will be characterized as having FD (functional dyspepsia, including the two subtypes [FD-EPS, FD-PDS]), chronic nausea vomiting syndrome, cyclic vomiting syndrome, and/or chronic abdominal pain syndrome to include demographic, clinical, psychological, nutritional characteristics, physiological measures, and serial assessments of symptoms over 3 years during their clinical care. Aim 2: Follow this well-characterized cohort to further define the natural history, clinical course, and selected physiologic measures of children and adolescents with symptoms of Gp. Aim 3: Provide a reliable source for recruitment of well-characterized children and adolescents with Gp and FD for other studies including therapeutic clinical trials, pathophysiological, molecular, histopathologic, or other ancillary studies. These subsequent clinical trials or ancillary studies will be conducted under separate study protocols with separate consent processes. Supplement Aim: Expand the number of pediatric sites within the PGpR2 to facilitate recruitment and consequently, the goals of the PGpR2. This innovative multidisciplinary approach will prospectively begin to fill the vast knowledge void regarding Gp and FD in children. The current supplement proposal is responsive to RFA-DK-20-504 and PA-20-272 by achieving among other goals, to build on our previous gains and expand the number of pediatric sites to enhance recruitment.

摘要 儿童和成人的胃轻瘫（Gp）的特征是在缺乏胃排空的情况下胃排空延迟。 机械性梗阻GP与显著的发病率和死亡率相关，但对其 儿童的发病率、患病率和自然史。儿科全科医生的这种知识差距因以下因素而加剧： 症状和病理生理学与功能性消化不良（FD）重叠，FD是成人常见疾病， 孩子有限的数据表明，临床症状和病理生理学之间的显着差异， 儿童与成人的GP和FD。因此，关于成人GP和FD的数据不太可能提供洞察力和填补 儿童对GP和FD的认识差距。这些问题（除其他外）突出表明， 儿童GP和FD特定的研究策略。因此，此补充应用程序的目标是构建 作为NIDDK胃轻瘫联盟的一部分， （GpCRC），最终确定通过生活质量衡量的疾病严重程度的因素， 症状目前项目的具体目标是： 目的1：建立一个国家前瞻性登记的儿童和青少年胃轻瘫GP）和GP样 综合征（GLS;后一组，使用儿科罗马IV标准将被表征为患有FD（功能性 消化不良，包括两种亚型[FD-EPS，FD-PDS]）、慢性恶心呕吐综合征、周期性呕吐 综合征和/或慢性腹痛综合征，以包括人口统计学、临床、心理、营养 特征、生理测量和3年以上临床期间症状的系列评估 在乎 目的2：遵循这一特征良好的队列，进一步确定自然史、临床病程和选择的 有GP症状的儿童和青少年的生理指标。 目标3：为招募特征明确的儿童和青少年GP和 FD用于其他研究，包括治疗性临床试验、病理生理学、分子学、组织病理学或其他 辅助研究。这些后续临床试验或辅助研究将在单独研究中进行 具有单独同意过程的协议。 补充目的：扩大PGpR 2中儿科研究中心的数量，以促进招募， 因此，PGPR 2的目标。 这一创新的多学科方法将有望开始填补关于 儿童的GP和FD。当前补充提案通过以下方式响应RFA-DK-20-504和PA-20-272 实现其他目标，建立在我们以前的成果和扩大儿科网站的数量，以提高 招聘

项目成果

Colonic motor response to wakening is blunted in slow transit constipation as detected by wireless motility capsule.

无线运动胶囊检测到，在慢传输型便秘中，结肠运动对唤醒的反应减弱。

• DOI: 10.1038/s41424-018-0012-9
• 发表时间: 2018
• 期刊: Clinical and translational gastroenterology
• 影响因子: 3.6
• 作者: Surjanhata,Brian;Barshop,Kenneth;Staller,Kyle;Semler,Jack;Guay,Laurence;Kuo,Braden
• 通讯作者: Kuo,Braden