New England Gastropareis Consortium: Neurobiology of Gastroparesis

新英格兰胃轻瘫联盟：胃轻瘫的神经生物学

• 批准号: 10842564
• 负责人: Braden Kuo
• 金额: $ 6.18万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-25 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10842564
• 关键词: Abdominal Pain; Adolescence; Adolescent; Adult; Ancillary Study; Assessment tool; COVID-19 pandemic effects; Categories; Characteristics; Child; Childhood; Chronic; Clinical; Clinical Research; Clinical Trials; Consent; Data; Development; Diabetes Mellitus; Disease; Distress; Dyspepsia; Epigastrium; Etiology; Functional Gastrointestinal Disorders; Functional disorder; Future; Gastric Emptying; Gastroparesis; General Population; Goals; Hospitalization; Incidence; Knowledge; Measures; Mechanics; Methodology; Methods; Molecular; Morbidity - disease rate; National Institute of Diabetes and Digestive and Kidney Diseases; Natural History; Nausea and Vomiting; Neurobiology; New England; Nutritional; Obstruction; Operative Surgical Procedures; Outcome Assessment; Pain; Patients; Periodicity; Physiological; Population; Prevalence; Process; Protocols documentation; Quality of life; Questionnaires; Registries; Research; Rome; Sample Size; Severities; Severity of illness; Site; Source; Stomach; Symptoms; Syndrome; Therapeutic Clinical Trial; Therapeutic Studies; Toddler; Treatment outcome; Vomiting; Work; adverse outcome; age group; age related; cell motility; chronic abdominal pain; clinical care; cohort; common symptom; comorbidity; cost; dietary; early satiety; effective therapy; gastrointestinal; improved; innovation; insight; interdisciplinary approach; mortality; neuropathology; pediatric patients; prospective; psychologic; psychosocial; recruit

ABSTRACT Gastroparesis (Gp) in children and adults is characterized by delayed gastric emptying in the absence of mechanical obstruction. GP is associated with significant morbidity and mortality, yet little is known regarding its incidence, prevalence, and natural history in children. This knowledge gap in pediatric Gp is exacerbated by the overlap in symptoms and pathophysiology with functional dyspepsia (FD), a common disorder in adults and children. The limited data suggests significant differences between clinical symptoms and pathophysiology of Gp and FD in children vs adults. Thus, data regarding Gp and FD in adults is unlikely to provide insight and fill the knowledge gaps regarding Gp and FD in children. These issues (among others) underscore the need for childhood Gp- and FD-specific research strategies. Thus, the goals of this supplemental application are to build on and extend our Pediatric Gp Registry 2 (PGpR2) work as part of the NIDDK Gastroparesis Consortium (GpCRC) ultimately, to determine the factors contributing to disease severity measured by quality of life and symptoms. The Specific Aims of the current project are to: Aim 1: Create a national prospective registry of children and adolescents with gastroparesis Gp) and Gp-like syndrome (GLS; the latter group, using pediatric Rome IV criteria will be characterized as having FD (functional dyspepsia, including the two subtypes [FD-EPS, FD-PDS]), chronic nausea vomiting syndrome, cyclic vomiting syndrome, and/or chronic abdominal pain syndrome to include demographic, clinical, psychological, nutritional characteristics, physiological measures, and serial assessments of symptoms over 3 years during their clinical care. Aim 2: Follow this well-characterized cohort to further define the natural history, clinical course, and selected physiologic measures of children and adolescents with symptoms of Gp. Aim 3: Provide a reliable source for recruitment of well-characterized children and adolescents with Gp and FD for other studies including therapeutic clinical trials, pathophysiological, molecular, histopathologic, or other ancillary studies. These subsequent clinical trials or ancillary studies will be conducted under separate study protocols with separate consent processes. Supplement Aim: Expand the number of pediatric sites within the PGpR2 to facilitate recruitment and consequently, the goals of the PGpR2. This innovative multidisciplinary approach will prospectively begin to fill the vast knowledge void regarding Gp and FD in children. The current supplement proposal is responsive to RFA-DK-20-504 and PA-20-272 by achieving among other goals, to build on our previous gains and expand the number of pediatric sites to enhance recruitment.

摘要

项目成果

Colonic motor response to wakening is blunted in slow transit constipation as detected by wireless motility capsule.

无线运动胶囊检测到，在慢传输型便秘中，结肠运动对唤醒的反应减弱。

• DOI: 10.1038/s41424-018-0012-9
• 发表时间: 2018
• 期刊: Clinical and translational gastroenterology
• 影响因子: 3.6
• 作者: Surjanhata,Brian;Barshop,Kenneth;Staller,Kyle;Semler,Jack;Guay,Laurence;Kuo,Braden
• 通讯作者: Kuo,Braden