Clinical Core

临床核心

• 批准号: 10321622
• 负责人: Pandurangan Vijayanand
• 金额: $ 1.24万
• 依托单位: LA JOLLA INSTITUTE FOR IMMUNOLOGY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10321622
• 关键词: Adolescent; Adult; Allergens; Allergic; Allergic Disease; Alternaria; Aspergillus; Asthma; Baltimore; Biological; Biological Specimen Banks; Blood Donations; Blood specimen; CD4 Positive T Lymphocytes; Child; Childhood; Childhood Asthma; Clinic; Clinical; Clinical Research; Code; Collaborations; Control Groups; Cost Savings; Data; Dictyoptera; Enrollment; Ensure; Epitopes; Equipment and supply inventories; Exposure to; Food; Food Hypersensitivity; Foundations; Funding; Future; Grant; Hospitals; Human; Human Subject Research; Individual; Institutional Review Boards; Lead; Measures; Molecular Profiling; Nose; Occupational; Office of Administrative Management; Outcome; Pathogenesis; Pediatric Hospitals; Peripheral Blood Mononuclear Cell; Plasma; Protocols documentation; Quality Control; Reagent; Resources; Role; Sampling; Site; Specimen; Sterility; T cell response; T-Lymphocyte; T-Lymphocyte Epitopes; Universities; Update; Validation; Whole Blood; Wisconsin; Wood material; Work; animal facility; asthmatic; central database; cockroach allergen; cohort; cost; data management; experimental study; human leukocyte antigen testing; inner city; mouse allergen; peripheral blood; programs; recruit; research study; safety study; success; urban setting

CORE SUMMARY The success of the entire program is contingent upon the availability of human specimens that will allow us to utilize allergen epitope-specific reagents to examine the role of allergen epitope-specific T cell responses in the pathogenesis and treatment of allergic diseases. To fulfill this need, the Clinical Core resource will provide peripheral blood and airway samples for T cell studies from well-characterized allergic and asthmatic subjects to be used in each of the scientific projects. As specifically suggested by the RFA, our approach will utilize either samples derived from NIAD-funded clinical networks and collaborators, or well-characterized samples specifically collected at LJI, most of which are already available in-house at LJI, providing a significant cost savings. Likewise, for the samples derived from clinical networks and collaborators, we rely on established collaborations and ongoing studies. Therefore, we are confident that the target cohorts will be successfully enrolled, and additional scientific input will be available, enabling the most robust and compelling studies. The Clinical Core will provide a centralized resource for accrual and inventory management of human PBMC, plasma and airway samples, and will ensure the quality and uniformity of handling of the samples received. These functions are crucial to provide a strong foundation for the studies described in the proposed projects. The Clinical Core will work closely with the Administrative and Data Management Cores, the individual Projects, and the various clinical subcontractors to enable success of all objectives in this program. This Core will be responsible for managing our inventory of human specimens, submitting and updating IRB protocols for current and new human subjects research, oversight of subject recruitment, quality control of clinical information, and HLA typing of donor samples.

核心摘要 整个计划的成功取决于人类标本的可用性，这将使我们能够 利用过敏原表位特异性试剂来检查过敏原表位特异性T细胞应答在免疫应答中的作用。 过敏性疾病的发病机制和治疗。为了满足这一需求，临床核心资源将提供 从充分表征的过敏和哮喘受试者中采集用于T细胞研究的外周血和气道样本 用于每一个科学项目。正如RFA特别建议的那样，我们的方法将利用 无论是来自NIAD资助的临床网络和合作者的样本，还是经过充分表征的样本， LJI专门收集的数据，其中大部分已经在LJI内部提供， 积蓄同样，对于来自临床网络和合作者的样本，我们依赖于已建立的 合作和持续研究。因此，我们相信目标群体将成功地 招募，并提供额外的科学投入，使最强大和引人注目的研究。的 临床中心将为人PBMC的累积和库存管理提供集中资源， 血浆和呼吸道样本，并将确保所收到的样本处理的质量和一致性。 这些职能对于为拟议项目中所述的研究奠定坚实的基础至关重要。 临床核心将与行政和数据管理核心密切合作， 项目和各个临床分包商，以确保该计划中所有目标的成功。这一核心 将负责管理我们的人体样本库存，提交和更新IRB方案， 当前和新的人类受试者研究，监督受试者招募，临床质量控制 信息和供体样本的HLA分型。