Biology of human cytotoxic CD4 T cells (CD4-CTLs) in viral infections

总体组件 COVID 19是一种严重的持续流行病。我们对这种疾病的免疫反应缺乏了解， 这损害了适当疗法和疫苗的开发。疫苗是成本最高的 有效和非常成功的医疗干预。大多数疫苗依赖于CD 4 T+细胞 以及它们对B细胞的帮助。过去，我们已经开发了多种新技术来研究人类CD 4 + T细胞。 几年来，这已经在我们的LJI CCHI实施。此处建议的补充将有助于 快速而有力地追求对人类T细胞对SARS-CoV 2反应的理解，这可能 帮助开发COVID 19的治疗方法和疫苗。

Overall Component COVID19 is a severe ongoing pandemic. Our understanding of the immune response to this disease is lacking, which impairs both the development of proper therapeutics and a vaccine. Vaccines are one of the most cost effective and extraordinarily successful medical interventions. Most of those vaccines depend on CD4 T+ cells and their help to B cells. We have developed multiple new techniques to study human CD4+ T cells over the past several years, which have have been implementing in our LJI CCHI. The supplement proposed here will facilitate rapid and vigorous pursuit of an understanding of the T cell responses to SARS-CoV2 in humans, which may help in the development of treatments and vaccines for COVID19.