Admin Core

在过去的一个世纪里，美国人的平均预期寿命增加了50%以上(从47岁增加到75岁 )，主要是通过消除因过早死亡而丧失的生命。在65岁及以上的人中， 慢性病是导致死亡的主要原因，并对寿命和生活质量造成重大负担。 减轻这些疾病对生活质量的影响的努力有限--导致 活动能力下降，身体虚弱，导致衰老进程加快。这项建议 约翰斯·霍普金斯中心将开展一项名为《骨骼和随年龄增长的关节退化》的项目 为肌肉骨骼研究，将专注于提高我们对细胞机制的理解 正常衰老会导致行动不便，增加疼痛和虚弱。为了支持中心目标，我们将 建立支持跨学科基础、临床所需的基础设施、资源和专业知识 和翻译研究，以调查我们的中心假设，即软骨下未耦合的重塑 骨和终板孔洞通过细胞衰老导致关节和脊柱退行性变 在正常衰老过程中出现疼痛、虚弱和活动障碍。 为确保有效运作和沟通，行政核心将提供必要的 基础设施和资源，以通过协调沟通和实现方案目标 四个项目和三个核心之间的努力。行政核心将通过四个方面实现这些目标 目标。第一个目标将建立行政框架，以支持个别科学项目和 通过几个监督机制，包括设立指导委员会和咨询委员会，加强对核心的监督。 第二个目标将为该方案的成功运作提供必要的行政支持 通过监测和管理项目赠款和核心预算，提供集中的 网络和交流平台，支持定期安排的会议。第三个目标将支持外展 约翰斯中心调查人员在更大的研究和医学界内的教育工作 霍普金斯大学和更远的地方。第四个目标将提供共同数据管理和统计分析 对中心调查人员的支持。 总而言之，行政核心将建立必要的基础设施和资源，以促进 确保中心项目成功的协作环境和核心，以加深我们的理解 在正常衰老过程中导致活动受限、疼痛和虚弱的细胞机制。

Over the past century, mean life expectancy in the United States has increased more than 50% (from 47 to 75 years), primarily through the elimination of lives lost due to premature death. Among those 65 years and older, chronic diseases are the leading cause of death and impose a major burden on longevity and quality of life. There have been limited efforts to attenuate the impact on quality of life that these diseases have – leading to decrease in mobility and development of frailty that lead to acceleration of the aging process. This proposed program project, “Skeleton and Joint Degeneration with Aging”, will be conducted by the Johns Hopkins Center for Musculoskeletal Research and will be focused on improving our understanding of cellular mechanisms in normal aging that lead to decreased mobility and increased pain and frailty. To support the Center goals, we will establish the infrastructure, resources, and expertise that are required to support interdisciplinary basic, clinical and translational research to investigate our central hypothesis that uncoupled remodeling of subchondral bone and endplate porosity through cellular senescence leads to joint and spinal degeneration and the development of pain, frailty, and mobility disorders during the normal aging process. To ensure efficient operation and communication, the Administrative Core will provide the necessary infrastructure and resources to achieve the program objectives through coordination of communication and efforts among the four projects and three cores. The Administrative Core will achieve these goals through four aims. The first aim will establish the administrative framework to support the individual scientific projects and cores through several mechanisms of oversight, including establishment of Steering and Advisory Committees. The second aim will provide the administrative support necessary for the successful operation of the program project grant through monitoring and management of the project and core budgets, provision of a centralized web and communication platform to support regularly scheduled meetings. The third aim will support outreach and education efforts of the Center investigators within the larger research and medical communities at Johns Hopkins University and beyond. The fourth aim will provide common data management and statistical analytic support for the Center investigators. In summary, the Administrative Core will establish the necessary infrastructure and resources to promote a collaborative environment to ensure the success of the Center projects and cores to further our understanding of the cellular mechanisms that lead to limited mobility, pain, and frailty during the normal aging process.