Admin Core

管理核心

• 批准号: 10090194
• 负责人: Xu Cao
• 金额: $ 28.88万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-01-15 至 2025-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10090194
• 关键词: Acceleration; Administrator; Advisory Committees; Aging; Arthralgia; Attenuated; Award; Basic Science; Budgets; Cause of Death; Cell Aging; Cells; Cessation of life; Chronic Disease; Clinical Research; Clinical Trials; Communication; Communities; Data; Development; Disease; Education and Outreach; Ensure; Faculty; Fibrinogen; Functional disorder; Funding; Goals; Grant; Histology; Individual; Infrastructure; Joints; Lead; Leadership; Life; Life Expectancy; Longevity; Medical; Mission; Monitor; Musculoskeletal; Online Systems; Output; Pain; Peptide Hydrolases; Phenotype; Physical Function; Physical activity; Porosity; Process; Productivity; Program Research Project Grants; Quality of life; Reporting; Research; Research Design; Research Personnel; Resources; Role; Schedule; Sclerosis; Secure; Services; Skeleton; Spinal; Statistical Data Interpretation; System; Tissues; Translational Research; United States; Universities; Vertebral column; Web communication; age related; chemokine; collaborative environment; cytokine; data management; frailty; improved; improved mobility; in vivo; joint destruction; meetings; normal aging; operation; osteoarthritis pain; premature; programs; senescence; subchondral bone; success

Over the past century, mean life expectancy in the United States has increased more than 50% (from 47 to 75 years), primarily through the elimination of lives lost due to premature death. Among those 65 years and older, chronic diseases are the leading cause of death and impose a major burden on longevity and quality of life. There have been limited efforts to attenuate the impact on quality of life that these diseases have – leading to decrease in mobility and development of frailty that lead to acceleration of the aging process. This proposed program project, “Skeleton and Joint Degeneration with Aging”, will be conducted by the Johns Hopkins Center for Musculoskeletal Research and will be focused on improving our understanding of cellular mechanisms in normal aging that lead to decreased mobility and increased pain and frailty. To support the Center goals, we will establish the infrastructure, resources, and expertise that are required to support interdisciplinary basic, clinical and translational research to investigate our central hypothesis that uncoupled remodeling of subchondral bone and endplate porosity through cellular senescence leads to joint and spinal degeneration and the development of pain, frailty, and mobility disorders during the normal aging process. To ensure efficient operation and communication, the Administrative Core will provide the necessary infrastructure and resources to achieve the program objectives through coordination of communication and efforts among the four projects and three cores. The Administrative Core will achieve these goals through four aims. The first aim will establish the administrative framework to support the individual scientific projects and cores through several mechanisms of oversight, including establishment of Steering and Advisory Committees. The second aim will provide the administrative support necessary for the successful operation of the program project grant through monitoring and management of the project and core budgets, provision of a centralized web and communication platform to support regularly scheduled meetings. The third aim will support outreach and education efforts of the Center investigators within the larger research and medical communities at Johns Hopkins University and beyond. The fourth aim will provide common data management and statistical analytic support for the Center investigators. In summary, the Administrative Core will establish the necessary infrastructure and resources to promote a collaborative environment to ensure the success of the Center projects and cores to further our understanding of the cellular mechanisms that lead to limited mobility, pain, and frailty during the normal aging process.

在过去的一个世纪里，美国的平均预期寿命增加了 50% 以上（从 47 岁增加到 75 岁） 年），主要是通过消除因过早死亡而丧失的生命。在 65 岁及以上的人群中， 慢性病是导致死亡的主要原因，对寿命和生活质量造成重大负担。 在减轻这些疾病对生活质量的影响方面所做的努力有限，导致 活动能力下降和身体虚弱，导致衰老过程加速。这个提议 计划项目“骨骼和关节退化与衰老”将由约翰·霍普金斯中心进行 用于肌肉骨骼研究，并将重点放在提高我们对细胞机制的理解 正常衰老会导致活动能力下降、疼痛和虚弱加剧。为了支持中心的目标，我们将 建立支持跨学科基础、临床所需的基础设施、资源和专业知识 和转化研究来调查我们的中心假设，即软骨下的解耦重塑 细胞衰老导致骨和终板孔隙化导致关节和脊柱退化， 在正常衰老过程中出现疼痛、虚弱和活动障碍。 为了确保有效的运作和沟通，行政核心将提供必要的 通过协调沟通和协调来实现计划目标的基础设施和资源 四个项目、三个核心的努力。行政核心将通过四个方面实现这些目标 目标。第一个目标是建立行政框架来支持各个科学项目和 核心是通过多种监督机制，包括设立指导委员会和咨询委员会。 第二个目标是为该计划的成功运作提供必要的行政支持 通过监测和管理项目和核心预算、提供集中的项目拨款 支持定期安排的会议的网络和通信平台。第三个目标将支持外展活动 以及中心研究人员在约翰斯大学更大的研究和医学界内的教育工作 霍普金斯大学及其他大学。第四个目标将提供通用的数据管理和统计分析 为中心调查人员提供支持。 总之，行政核心将建立必要的基础设施和资源，以促进 确保中心项目和核心项目成功的协作环境，以加深我们的理解 正常衰老过程中导致活动受限、疼痛和虚弱的细胞机制。