Motion Processing by Interactions of Receptive Field Center and Surround in Primate Retinal Ganglion Cells

灵长类动物视网膜神经节细胞感受野中心和周围相互作用的运动处理

• 批准号: 10326365
• 负责人: Todd Appleby
• 金额: $ 4.19万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10326365
• 关键词: Anatomy; Area; Cell physiology; Cells; Data; Electrophysiology (science); Goals; Human; Macaca; Measurement; Measures; Mediating; Modeling; Monkeys; Motion; Oryctolagus cuniculus; Output; Physiological; Primates; Publications; Research; Research Design; Retina; Retinal Ganglion Cells; Role; Salamander; Signal Transduction; Spottings; Stimulus; Structure; Synapses; Techniques; Testing; Vision; Visual; Visual Cortex; Visual system structure; Work; antagonist; cell type; design; experimental study; ganglion cell; next generation; novel; object motion; receptive field; response; retinal prosthesis; sensory system; visual processing

PROJECT SUMMARY The overall goal of this proposal is to understand the role of interactions between the receptive field center and surround in encoding motion signals in sparsely expressed retinal ganglion cells of the macaque monkey retina. Studies of primate retinal ganglion cell physiologies have largely been limited to 5 dominantly expressed types. This proposal will contribute to our understanding of three poorly understood and sparsely expressed ganglion cell types: the broad thorny, the ON smooth monostratified, and the OFF smooth monostratified. These three types will be characterized in terms of center-surround interactions that contribute to each ganglion cell’s functional output. The proposed research has two specific aims: 1) To determine whether surround motion facilitates spiking outputs of smooth monostratified ganglion cells. I will record synaptic inputs and spiking outputs of smooth monostratified ganglion cells to measure ganglion cell sensitivity when a motion stimulus is presented to the surround. I will test the specific hypothesis that despite showing a traditionally suppressive surround to stationary spots, the smooth monostratified cell’s spiking output is facilitated by motion in the surround. 2) To determine whether center and surround interact to create selectivity for object motion in the broad thorny ganglion cell. I will measure synaptic inputs and spiking outputs of the broad thorny ganglion cell to determine whether motion in the broad thorny surround is suppressive to all visual inputs except object motion. My experiments will test the specific hypothesis that surround motion makes the broad thorny sensitive to differential motion.

项目摘要 这个建议的总体目标是了解感受野中心之间相互作用的作用 在猕猴稀疏表达的视网膜神经节细胞中， 视网膜。灵长类动物视网膜神经节细胞生理学的研究主要限于5种主要的 表达类型。这一建议将有助于我们了解三个知之甚少和稀疏 表达的神经节细胞类型：宽刺，ON光滑单层，和OFF光滑 单层的这三种类型的特点是中心-周围的相互作用， 对每个神经节细胞的功能输出都有贡献。 拟议的研究有两个具体目标： 1)确定环绕运动是否促进平滑单层神经节细胞的尖峰输出。 我将记录突触输入和尖峰输出的平滑单层神经节细胞，以测量 神经节细胞的敏感性，当运动刺激呈现给周围。我会测试 假设，尽管显示出传统上抑制周围静止点，平滑 单层细胞的尖峰输出由周围的运动促进。 2)要确定中心和环绕是否相互作用，以创建对象运动的选择性， 多刺神经节细胞。我将测量突触输入和宽刺神经节细胞的尖峰输出， 确定在宽的多刺环境中的运动是否抑制除对象之外的所有视觉输入 议案我的实验将验证一个特定的假设，即环绕运动使广阔的荆棘 对差动运动敏感。