Motion Processing by Interactions of Receptive Field Center and Surround in Primate Retinal Ganglion Cells

项目总结 本提案的总体目标是了解接受能力较强的场地中心之间的交互作用 在猕猴稀疏表达的视网膜神经节细胞中编码运动信号 视网膜。对灵长类视网膜神经节细胞生理学的研究主要局限于5种 表示类型。这一建议将有助于我们理解三个鲜为人知的和稀少的 表达的神经节细胞类型：宽棘型、单层光滑型和光滑型 单层的。这三种类型将根据中心-周围相互作用来描述 为每个神经节细胞的功能输出做出贡献。 这项拟议的研究有两个具体目标： 1)确定周围运动是否促进平滑单层神经节细胞的尖峰输出。 我将记录平滑单层神经节细胞的突触输入和尖峰输出来测量 当运动刺激呈现给周围时，神经节细胞的敏感性。我会测试一下具体的 假设，尽管传统上显示出对静止光点的抑制环绕，但平滑的 单层细胞的尖峰输出是由周围的运动促进的。 2)确定中心和周围是否相互作用以在较大范围内为对象运动创建选择性 多刺的神经节细胞。我将测量宽阔的棘神经节细胞的突触输入和尖峰输出 确定在多刺的宽阔环境中的运动是否抑制除对象之外的所有视觉输入 动议。我的实验将检验一个具体的假设，即环绕运动使宽广的 对差动敏感的。

PROJECT SUMMARY The overall goal of this proposal is to understand the role of interactions between the receptive field center and surround in encoding motion signals in sparsely expressed retinal ganglion cells of the macaque monkey retina. Studies of primate retinal ganglion cell physiologies have largely been limited to 5 dominantly expressed types. This proposal will contribute to our understanding of three poorly understood and sparsely expressed ganglion cell types: the broad thorny, the ON smooth monostratified, and the OFF smooth monostratified. These three types will be characterized in terms of center-surround interactions that contribute to each ganglion cell’s functional output. The proposed research has two specific aims: 1) To determine whether surround motion facilitates spiking outputs of smooth monostratified ganglion cells. I will record synaptic inputs and spiking outputs of smooth monostratified ganglion cells to measure ganglion cell sensitivity when a motion stimulus is presented to the surround. I will test the specific hypothesis that despite showing a traditionally suppressive surround to stationary spots, the smooth monostratified cell’s spiking output is facilitated by motion in the surround. 2) To determine whether center and surround interact to create selectivity for object motion in the broad thorny ganglion cell. I will measure synaptic inputs and spiking outputs of the broad thorny ganglion cell to determine whether motion in the broad thorny surround is suppressive to all visual inputs except object motion. My experiments will test the specific hypothesis that surround motion makes the broad thorny sensitive to differential motion.