The Next Generation of Innovative Cardiovascular Clinical/Translational Researchers

项目摘要/摘要 我的职业重点是减少早期心血管疾病(CVD)风险的研究和教育工作 各种因素。肥胖、糖尿病和潜在的胰岛素抵抗(IR)是心血管疾病的主要贡献者，由 目前儿童肥胖症的流行。青年2型糖尿病(T2D)患者的独特因素导致早期胰岛素 加速心血管疾病和死亡率的并存疾病以及典型的成人T2D的依赖和进展 治疗对年轻人无效。T1D中IR的机制也不清楚，限制了我们降低 T1D的心血管风险。此外，目前的简历评估工具对年轻人来说往往太具侵入性。我之前的研究 培训、初步领导经验以及与心脏病学、生物工程学和放射学的合作 提供技能和综合专业知识来解决这些严重的空白。NHLBI K24拨款将训练我 更好地为专注于心血管疾病的内科医生-科学家提供高影响力POR方面的指导 培养多样化的新调查人员。我的职业目标是：1)更好地理解早期的前兆 在缺乏服务的肥胖/糖尿病青年人群中的心血管疾病2)开发非侵入性方法 3)开发降低心血管疾病风险的新的内科和/或外科治疗方法 在青年和4)学习如何最好地参与，激励和培训不同的新兴研究人员在切割- 边缘位置。作为K24奖学金获得者的支持将提供专门的时间来受益于特殊的POR 指导和领导力培训资源，我们的校园和其他地方，并专注于这些目标。 我的K24应用程序包括以下概述：1)我在POR中的技能、记录和对指导工作的奉献精神；2)A) 减少行政/临床责任并专注于指导的战略；3)有影响力的尖端K24 POR计划，为学员提供大量机会；4)将专家合作者整合为 K24咨询委员会为青少年提供卓越和有凝聚力的培训、指导和监督 同事和确保未来实习生的管道；5)证据表明有强大的早期职业保护池 POR调查人员受益于K24支持；6)负责任的研究行为培训时间表；7) 我的POR计划背后的合作者、机构和环境支持的证据 K24提案。 作为NHLBI K24学者，我的目标是：1)加强对不同早期职业的指导 调查人员将建立一条训练有素的内科科学家管道，专注于心血管疾病POR。基本原理： 拟议的培训计划为在CVD创建POR职业生涯提供了特殊的支持、环境和专业知识 预防。我将把我目前的指导技能与从K24中获得的技能相结合，以提供最高的 高质量的导师。2)。以我在青少年发病型肥胖/糖尿病方面的心血管风险降低POR为基础。 理由：有了K24的支持，我可以提升我们POR研究的质量和广度，以及 从而改善越来越多肥胖和糖尿病青年的生活。

Project Summary/Abstract My career focus is research and educational efforts to reduce early cardiovascular disease (CVD) risk factors. Obesity, diabetes, and underlying insulin resistance (IR) are major contributors to CVD, accelerated by the current pediatric obesity epidemic. Unique factors in youth with type 2 diabetes (T2D) lead to early insulin dependence and progression of co-morbidities that accelerate CVD and mortality, and typical adult T2D treatments are ineffective in youth. The mechanism of IR in T1D is also unclear, limiting our ability to reduce CVD risk in T1D. Moreover, current CV-assessment tools are often too invasive for youth. My prior research training, initial leadership experiences and collaborations with cardiology, bioengineering, and radiology provide the skills and combined expertise to address these critical voids. An NHLBI K24 grant will train me to better provide mentorship in high-impact POR to CVD-focused physician-scientists of exceptional potential and nurture a diverse pipeline of new investigators. My career goals are to: 1) Better understand early precursors of CVD in the underserved population of youth with obesity/diabetes 2) Develop non-invasive approaches to CVD risk-assessment tolerable to youth 3) Develop new medical and/or surgical treatments to reduce CVD risk in youth and 4) Learn how to best engage, motivate and train a diverse set of emerging researchers in cutting- edge POR. Support as a K24 scholar will provide dedicated time to benefit from the exceptional POR mentoring and leadership training resources of our campus and beyond, and focus on these goals. My K24 application includes an overview of: 1) My skills, record and dedication to mentoring in POR; 2) A strategy to reduce administrative/clinical obligations and focus on mentoring; 3) An impactful, cutting-edge K24 POR proposal with numerous opportunities for trainees; 4) A strategy for integrating expert collaborators as a K24 Advisory Committee to deliver superior and cohesive training, mentoring and oversight of junior colleagues and to assure a pipeline of future trainees; 5) Evidence of a robust pool of protected early career POR investigators to benefit from K24 support; 6) A timeline for training in responsible conduct of research; 7) Evidence of the collaborator, institutional and environmental support underlying my POR program and for the K24 proposal. My Aims as an NHLBI K24 Scholar are to: 1) Strengthen mentoring of a diverse set of early career investigators to create a pipeline of well-trained physician-scientists focused on CVD POR. Rationale: The proposed training plan offers exceptional support, environment and expertise for creating a POR career in CVD prevention. I will integrate my current mentoring skills with those gained from the K24, to deliver the highest quality mentorship. 2). Build upon my CVD risk-reduction POR in youth-onset obesity/diabetes. Rationale: Given K24 support, I am positioned to enhance the quality and breadth of our POR research, and thereby improve the lives of the growing numbers of youth with obesity and diabetes.