The Next Generation of Innovative Cardiovascular Clinical/Translational Researchers

下一代创新型心血管临床/转化研究人员

• 批准号: 10327672
• 负责人: KRISTEN Jane NADEAU
• 金额: $ 11.49万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10327672
• 关键词: Address; Adult; Advisory Committees; Assessment tool; Biomedical Engineering; Cardiology; Cardiovascular Diseases; Cardiovascular system; Childhood; Childhood diabetes; Circadian desynchrony; Clinical; Collaborations; Coupled; Dedications; Dependence; Development; Diabetes Mellitus; Diabetic Nephropathy; Dyslipidemias; Endocrinology; Environment; Functional disorder; Future; Generations; Goals; Grant; Hypertension; Insulin; Insulin Resistance; Insulin-Dependent Diabetes Mellitus; Lead; Leadership; Learning; Link; Literature; Longevity; Medical; Medicine; Mentors; Mentorship; Minority Groups; National Heart, Lung, and Blood Institute; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Obesity Epidemic; Operative Surgical Procedures; Parents; Physicians; Polycystic Ovary Syndrome; Positioning Attribute; Prevalence; Prevention Research; Radiology Specialty; Research; Research Personnel; Research Proposals; Research Training; Resources; Risk Assessment; Risk Factors; Risk Reduction; Scientist; Sleep Apnea Syndromes; Structure of beta Cell of islet; Time; TimeLine; Training; Underrepresented Minority; Underserved Population; United States National Institutes of Health; Youth; cardiovascular disorder prevention; cardiovascular disorder risk; career; cohesion; comorbidity; experience; fitness; improved; ineffective therapies; innovation; insulin dependent diabetes mellitus onset; insulin secretion; medical schools; minority children; mortality; next generation; obesity in children; patient oriented research; programs; responsible research conduct; skills; translational scientist; trend

Project Summary/Abstract My career focus is research and educational efforts to reduce early cardiovascular disease (CVD) risk factors. Obesity, diabetes, and underlying insulin resistance (IR) are major contributors to CVD, accelerated by the current pediatric obesity epidemic. Unique factors in youth with type 2 diabetes (T2D) lead to early insulin dependence and progression of co-morbidities that accelerate CVD and mortality, and typical adult T2D treatments are ineffective in youth. The mechanism of IR in T1D is also unclear, limiting our ability to reduce CVD risk in T1D. Moreover, current CV-assessment tools are often too invasive for youth. My prior research training, initial leadership experiences and collaborations with cardiology, bioengineering, and radiology provide the skills and combined expertise to address these critical voids. An NHLBI K24 grant will train me to better provide mentorship in high-impact POR to CVD-focused physician-scientists of exceptional potential and nurture a diverse pipeline of new investigators. My career goals are to: 1) Better understand early precursors of CVD in the underserved population of youth with obesity/diabetes 2) Develop non-invasive approaches to CVD risk-assessment tolerable to youth 3) Develop new medical and/or surgical treatments to reduce CVD risk in youth and 4) Learn how to best engage, motivate and train a diverse set of emerging researchers in cutting- edge POR. Support as a K24 scholar will provide dedicated time to benefit from the exceptional POR mentoring and leadership training resources of our campus and beyond, and focus on these goals. My K24 application includes an overview of: 1) My skills, record and dedication to mentoring in POR; 2) A strategy to reduce administrative/clinical obligations and focus on mentoring; 3) An impactful, cutting-edge K24 POR proposal with numerous opportunities for trainees; 4) A strategy for integrating expert collaborators as a K24 Advisory Committee to deliver superior and cohesive training, mentoring and oversight of junior colleagues and to assure a pipeline of future trainees; 5) Evidence of a robust pool of protected early career POR investigators to benefit from K24 support; 6) A timeline for training in responsible conduct of research; 7) Evidence of the collaborator, institutional and environmental support underlying my POR program and for the K24 proposal. My Aims as an NHLBI K24 Scholar are to: 1) Strengthen mentoring of a diverse set of early career investigators to create a pipeline of well-trained physician-scientists focused on CVD POR. Rationale: The proposed training plan offers exceptional support, environment and expertise for creating a POR career in CVD prevention. I will integrate my current mentoring skills with those gained from the K24, to deliver the highest quality mentorship. 2). Build upon my CVD risk-reduction POR in youth-onset obesity/diabetes. Rationale: Given K24 support, I am positioned to enhance the quality and breadth of our POR research, and thereby improve the lives of the growing numbers of youth with obesity and diabetes.

项目概要/摘要 我的职业重点是降低早期心血管疾病 (CVD) 风险的研究和教育工作 因素。肥胖、糖尿病和潜在的胰岛素抵抗 (IR) 是 CVD 的主要原因，而这些因素又加速了 CVD 的发生 当前小儿肥胖流行。患有 2 型糖尿病 (T2D) 的青少年的独特因素导致早期使用胰岛素 加速 CVD 和死亡率的合并症的依赖性和进展，以及典型的成人 T2D 治疗对青少年无效。 T1D 中 IR 的机制也不清楚，这限制了我们减少 T1D 的能力 T1D 的 CVD 风险。此外，当前的简历评估工具对于年轻人来说往往过于具有侵入性。我之前的研究 培训、初步领导经验以及与心脏病学、生物工程和放射学的合作 提供技能和综合专业知识来解决这些关键空白。 NHLBI K24 补助金将训练我 更好地为具有特殊潜力和能力的专注于 CVD 的医师科学家提供高影响力 POR 方面的指导 培养多元化的新研究人员。我的职业目标是：1）更好地理解早期先驱 2) 开发非侵入性方法 青少年可耐受的 CVD 风险评估 3) 开发新的医疗和/或外科治疗方法以降低 CVD 风险 4) 了解如何最好地吸引、激励和培训各种新兴研究人员进行切割- 边沿 POR。作为 K24 学者的支持将提供专门的时间来从特殊的 POR 中受益 我们校园内外的指导和领导力培训资源，并专注于这些目标。 我的 K24 申请包括以下概述： 1) 我在 POR 指导方面的技能、记录和奉献精神； 2）A 减少行政/临床义务并注重指导的战略； 3) 具有影响力的尖端 K24 POR 提案为学员提供了大量机会； 4) 将专家合作者整合为一个战略 K24 咨询委员会为初级学生提供卓越且有凝聚力的培训、指导和监督 同事并确保未来学员的渠道； 5) 有证据表明有大量受保护的早期职业 POR 调查员将从 K24 支持中受益； 6) 负责任的研究行为培训时间表； 7） 我的 POR 计划的合作者、机构和环境支持的证据以及 K24提案。 作为 NHLBI K24 学者，我的目标是： 1) 加强对各种早期职业生涯的指导 研究人员创建了一批训练有素的医师科学家，专注于 CVD POR。理由： 拟议的培训计划为在 CVD 领域创建 POR 职业提供卓越的支持、环境和专业知识 预防。我会将我目前的指导技能与 K24 中获得的技能相结合，以提供最高的指导 高质量的指导。 2）。以我针对青少年肥胖/糖尿病的 CVD 风险降低 POR 为基础。 理由：在 K24 的支持下，我有能力提高 POR 研究的质量和广度，并且 从而改善越来越多患有肥胖症和糖尿病的青少年的生活。