The Next Generation of Innovative Cardiovascular Clinical/Translational Researchers

项目总结/摘要 我的职业重点是研究和教育工作，以减少早期心血管疾病（CVD）的风险 因素肥胖、糖尿病和潜在的胰岛素抵抗（IR）是CVD的主要原因， 儿童肥胖症的流行2型糖尿病（T2 D）青年患者的独特因素导致早期胰岛素 加速CVD和死亡率的合并症的依赖性和进展，以及典型的成人T2 D 治疗对年轻人无效。T1 D中IR的机制也不清楚，限制了我们减少IR的能力。 T1 D的CVD风险。此外，目前的CV评估工具对年轻人来说往往过于侵入性。我之前的研究 培训、初步领导经验以及与心脏病学、生物工程学和放射学的合作 提供技能和综合专业知识，以解决这些关键的空白。一个NHLBI K24赠款将训练我， 在高影响力POR中，更好地为具有特殊潜力的心血管疾病医生-科学家提供指导， 培养新调查人员的多样化渠道。我的职业目标是：1）更好地了解早期前兆 2）开发非侵入性方法， 年轻人可耐受的心血管疾病风险评估3）开发新的药物和/或手术治疗，以降低心血管疾病风险 在青年和4）学习如何最好地参与，激励和培训一系列新兴的研究人员在切割- 边缘POR。作为K24学者的支持将提供专门的时间来从特殊的POR中受益 我们校园及其他地区的指导和领导力培训资源，并专注于这些目标。 我的K24应用程序包括概述：1）我的技能，记录和奉献精神，指导在POR; 2） 减少行政/临床义务并专注于指导的战略; 3）有影响力的尖端K24 为受训人员提供大量机会的POR提案; 4）将专家合作者作为一个 K24咨询委员会为初级员工提供上级和有凝聚力的培训、指导和监督 5）有证据表明，有一个强大的受保护的早期职业生涯库， POR研究者将受益于K24的支持; 6）负责开展研究的培训时间轴; 7） 合作者的证据，机构和环境支持我的POR计划和 K24提案。 我作为NHLBI K24学者的目标是：1）加强对早期职业生涯的指导 研究人员创建了一个训练有素的医生，科学家的管道，专注于CVD POR。理由： 拟议的培训计划提供了特殊的支持，环境和专业知识，为创造一个POR的职业生涯在CVD 预防我将把我目前的指导技能与从K24中获得的技能相结合， 质量指导。2）。建立在我的心血管疾病风险降低POR在青年发病肥胖/糖尿病。 理由：鉴于K24的支持，我的定位是提高我们POR研究的质量和广度， 从而改善越来越多的肥胖和糖尿病青年的生活。

Project Summary/Abstract My career focus is research and educational efforts to reduce early cardiovascular disease (CVD) risk factors. Obesity, diabetes, and underlying insulin resistance (IR) are major contributors to CVD, accelerated by the current pediatric obesity epidemic. Unique factors in youth with type 2 diabetes (T2D) lead to early insulin dependence and progression of co-morbidities that accelerate CVD and mortality, and typical adult T2D treatments are ineffective in youth. The mechanism of IR in T1D is also unclear, limiting our ability to reduce CVD risk in T1D. Moreover, current CV-assessment tools are often too invasive for youth. My prior research training, initial leadership experiences and collaborations with cardiology, bioengineering, and radiology provide the skills and combined expertise to address these critical voids. An NHLBI K24 grant will train me to better provide mentorship in high-impact POR to CVD-focused physician-scientists of exceptional potential and nurture a diverse pipeline of new investigators. My career goals are to: 1) Better understand early precursors of CVD in the underserved population of youth with obesity/diabetes 2) Develop non-invasive approaches to CVD risk-assessment tolerable to youth 3) Develop new medical and/or surgical treatments to reduce CVD risk in youth and 4) Learn how to best engage, motivate and train a diverse set of emerging researchers in cutting- edge POR. Support as a K24 scholar will provide dedicated time to benefit from the exceptional POR mentoring and leadership training resources of our campus and beyond, and focus on these goals. My K24 application includes an overview of: 1) My skills, record and dedication to mentoring in POR; 2) A strategy to reduce administrative/clinical obligations and focus on mentoring; 3) An impactful, cutting-edge K24 POR proposal with numerous opportunities for trainees; 4) A strategy for integrating expert collaborators as a K24 Advisory Committee to deliver superior and cohesive training, mentoring and oversight of junior colleagues and to assure a pipeline of future trainees; 5) Evidence of a robust pool of protected early career POR investigators to benefit from K24 support; 6) A timeline for training in responsible conduct of research; 7) Evidence of the collaborator, institutional and environmental support underlying my POR program and for the K24 proposal. My Aims as an NHLBI K24 Scholar are to: 1) Strengthen mentoring of a diverse set of early career investigators to create a pipeline of well-trained physician-scientists focused on CVD POR. Rationale: The proposed training plan offers exceptional support, environment and expertise for creating a POR career in CVD prevention. I will integrate my current mentoring skills with those gained from the K24, to deliver the highest quality mentorship. 2). Build upon my CVD risk-reduction POR in youth-onset obesity/diabetes. Rationale: Given K24 support, I am positioned to enhance the quality and breadth of our POR research, and thereby improve the lives of the growing numbers of youth with obesity and diabetes.